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Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Yifei Chen , Shenghao Zhu , Zhaojie Fang , Chang Liu , Binfeng Zou , Yuhe Wang , Shuo Chang , Fan Jia , Feiwei Qin , Jin Fan , Yong Peng , Changmiao Wang

Alzheimer's disease (AD) is an irreversible, progressive neuro degenerative disorder that slowly destroys memory and thinking skills and eventually, the ability to carry out the simplest tasks. In this paper, a deep neural network based…

Image and Video Processing · Electrical Eng. & Systems 2021-05-17 Manu Subramoniam , Aparna T. R. , Anurenjan P. R. , Sreeni K. G

Alzheimer's disease (AD) is a devastating neurodegenerative condition that precedes progressive and irreversible dementia; thus, predicting its progression over time is vital for clinical diagnosis and treatment. Numerous studies have…

Artificial Intelligence · Computer Science 2023-10-06 Seungwoo Jeong , Wonsik Jung , Junghyo Sohn , Heung-Il Suk

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative

Early and accurate diagnosis of Alzheimer's disease (AD) remains a critical challenge in neuroimaging-based clinical decision support systems. In this work, we propose a novel hybrid deep learning framework that integrates Topological Data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Faisal Ahmed

High-dimensional neuroimaging data presents challenges for assessing neurodegenerative diseases due to complex non-linear relationships. Variational Autoencoders (VAEs) can encode scans into lower-dimensional latent spaces capturing…

Accurate early diagnosis and monitoring of neurodegenerative conditions is essential for effective disease management and delivery of medication and treatment. This research develops automatic methods for detecting brain imaging preclinical…

Neural and Evolutionary Computing · Computer Science 2019-10-15 Amir Dehsarvi , Stephen L. Smith

Objective: This study aims to support early diagnosis of Alzheimer's disease and detection of amyloid accumulation by leveraging the microstructural information available in multi-shell diffusion MRI (dMRI) data, using a vision…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Quentin Dessain , Nicolas Delinte , Bernard Hanseeuw , Laurence Dricot , Benoît Macq

Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Background and Aim: Accurate classification of Magnetic Resonance Images (MRI) is essential to accurately predict Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) conversion. Meanwhile, deep learning has been successfully…

Computer Vision and Pattern Recognition · Computer Science 2021-09-03 Kshitiz Shrestha , Omar Hisham Alsadoon , Abeer Alsadoon , Tarik A. Rashid , Rasha S. Ali , P. W. C. Prasad , Oday D. Jerew

The automatic early diagnosis of prodromal stages of Alzheimer's disease is of great relevance for patient treatment to improve quality of life. We address this problem as a multi-modal classification task. Multi-modal data provides richer…

Deciphering visual content from functional Magnetic Resonance Imaging (fMRI) helps illuminate the human vision system. However, the scarcity of fMRI data and noise hamper brain decoding model performance. Previous approaches primarily…

Computer Vision and Pattern Recognition · Computer Science 2024-06-14 Yulong Liu , Yongqiang Ma , Guibo Zhu , Haodong Jing , Nanning Zheng

Diagnosing Autism Spectrum Disorder (ASD) is a challenging problem, and is based purely on behavioral descriptions of symptomology (DSM-5/ICD-10), and requires informants to observe children with disorder across different settings (e.g.…

Neurons and Cognition · Quantitative Biology 2020-03-04 Taban Eslami , Joseph S. Raiker , Fahad Saeed

Traditional supervised learning with deep neural networks requires a tremendous amount of labelled data to converge to a good solution. For 3D medical images, it is often impractical to build a large homogeneous annotated dataset for a…

Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide, necessitating early and accurate diagnosis for optimal patient management. In recent years, advancements in deep learning have shown remarkable potential…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Taymaz Akan , Sait Alp , Md. Shenuarin Bhuiyan , Elizabeth A. Disbrow , Steven A. Conrad , John A. Vanchiere , Christopher G. Kevil , Mohammad A. N. Bhuiyan

Neural network-based anomaly detection remains challenging in clinical applications with little or no supervised information and subtle anomalies such as hardly visible brain lesions. Among unsupervised methods, patch-based auto-encoders…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Nicolas Pinon , Geoffroy Oudoumanessah , Robin Trombetta , Michel Dojat , Florence Forbes , Carole Lartizien

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

In recent years, analyzing task-based fMRI (tfMRI) data has become an essential tool for understanding brain function and networks. However, due to the sheer size of tfMRI data, its intrinsic complex structure, and lack of ground truth of…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-03-06 Milad Makkie , Heng Huang , Yu Zhao , Athanasios V. Vasilakos , Tianming Liu

Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have shown promise in Alzheimer's disease…

Image and Video Processing · Electrical Eng. & Systems 2024-07-03 Gia Minh Hoang , Youngjoo Lee , Jae Gwan Kim

As the prevalence of Alzheimer's disease (AD) rises, improving mechanistic insight from non-invasive biomarkers is increasingly critical. Recent work suggests that circuit-level brain alterations manifest as changes in…

Neural and Evolutionary Computing · Computer Science 2026-02-10 Szymon Mamoń , Max Talanov , Alessandro Crimi