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We study in a general mathematical framework the optimal allocation of vaccine in an heterogeneous population. We cast the problem of optimal vaccination as a bi-objective minimization problem min(C($\eta$),L($\eta$)), where C and L stand…

Optimization and Control · Mathematics 2025-03-21 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

We formalize and study the problem of optimal allocation strategies for a (perfect) vaccine in the infinite-dimensional SIS model. The question may be viewed as a bi-objective minimization problem, where one tries to minimize simultaneously…

Probability · Mathematics 2021-08-27 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

Heterogeneity of population is a key factor in modeling the transmission of disease among the population and has huge impact on the outcome of the transmission. In order to investigate the decision making process in the heterogeneous mixing…

Populations and Evolution · Quantitative Biology 2024-03-01 Fan Bai , Qianyu Chen , Yizhuo Xu

In previous articles, we formalized the problem of optimal allocation strategies for a (perfect) vaccine in an infinite-dimensional metapopulation model. The aim of the current paper is to illustrate this theoretical framework with multiple…

Optimization and Control · Mathematics 2021-12-17 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

How to allocate vaccines over heterogeneous individuals is one of the important policy decisions in pandemic times. This paper develops a procedure to estimate an individualized vaccine allocation policy under limited supply, exploiting…

Econometrics · Economics 2021-10-25 Toru Kitagawa , Guanyi Wang

This present results lay the foundations for the study of the optimal allocation of vaccine in the simple epidemiological SIS model where one consider a very general heterogeneous population. In the present setting each individual has a…

Populations and Evolution · Quantitative Biology 2025-04-02 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

We consider the problem of optimal allocation strategies for a (perfect) vaccine in an infinite-metapopulation model (including SIS, SIR, SEIR,. . .), when the loss function is given by the effective reproduction number Re, which is defined…

Optimization and Control · Mathematics 2021-10-26 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in…

Populations and Evolution · Quantitative Biology 2016-03-29 Chantal Nguyen , Jean M. Carlson

We consider a SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of…

Probability · Mathematics 2021-02-26 Emanuel Javier Ferreyra , Matthieu Jonckheere , Juan Pablo Pinasco

We consider the simple epidemiological SIS model for a general heterogeneous population introduced by Lajmanovich and Yorke (1976) in finite dimension, and its infinite dimensional generalization we introduced in previous works. In this…

Dynamical Systems · Mathematics 2022-11-29 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

Vaccinations are an important tool in the prevention of disease. Vaccinations are generally voluntary for each member of a population and vaccination decisions are influenced by individual risk perceptions and contact structures within…

Physics and Society · Physics 2025-04-07 Kausutua Tjikundi , Mark Broom

We propose and solve an optimal vaccination problem within a deterministic compartmental model of SIRS type: the immunized population can become susceptible again, e.g.\ because of a not complete immunization power of the vaccine. A social…

Optimization and Control · Mathematics 2022-06-08 Salvatore Federico , Giorgio Ferrari , Maria-Laura Torrente

In this paper we consider SIR epidemics on random graphs with clustering. To incorporate group structure of the underlying social network, we use a generalized version of the configuration model in which each node is a member of a specified…

Probability · Mathematics 2018-02-15 Carolina Fransson , Pieter Trapman

SIR models, also with age structure, can be used to describe the evolution of an infective disease. A vaccination campaign influences this dynamics immunizing part of the susceptible individuals, essentially turning them into recovered…

Analysis of PDEs · Mathematics 2019-10-17 Rinaldo M. Colombo , Mauro Garavello

We consider the problem of controlling the propagation of an epidemic outbreak in an arbitrary contact network by distributing vaccination resources throughout the network. We analyze a networked version of the…

Social and Information Networks · Computer Science 2013-03-19 Victor M. Preciado , Michael Zargham , Chinwendu Enyioha , Ali Jadbabaie , George Pappas

Optimization of vaccine allocations among different segments of a heterogeneous population is important for enhancing the effectiveness of vaccination campaigns in reducing the burden of epidemics. Intuitively, it would seem that…

Quantitative Methods · Quantitative Biology 2022-12-01 Nir Gavish , Guy Katriel

Controlling and understanding epidemic outbreaks has recently drawn great interest in a large spectrum of research communities. Vaccination is one of the most well-established and effective strategies in order to contain an epidemic. In the…

Social and Information Networks · Computer Science 2023-05-29 Sourin Chatterjee , Ahad N. Zehmakan

The containment of epidemic spreading is a major challenge in science. Vaccination, whenever available, is the best way to prevent the spreading, because it eventually immunizes individuals. However, vaccines are not perfect, and total…

In this paper we aim to study an optimal insurance premium level for health-care in a deterministic and stochastic SIR models with migration fluxes and vaccination of population. The studied model considers two standard SIR centres…

Populations and Evolution · Quantitative Biology 2019-10-14 Aleksandr A. Shemendyuk , Alexey A. Chernov , Mark Y Kelbert

Inspired by contagion models of social belief formation, we develop an epistemically-informed modeling framework, SIS-Vo, in which vaccine-related information propagates on a signed opinion network. Our model allows for heterogeneous…

Physics and Society · Physics 2026-05-22 Alessandro Casu , Camilla Quaresmini , Robin Delabays , Lewis Mitchell , Philip E. Paré
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