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Myocardial infarction causes myocardium thinning, fibrosis, and progressive heart failure. Engineered human myocardium (EHM) is tested clinically as a first-in-class product for sustainable remuscularization in patients with advanced heart…

Medical Physics · Physics 2025-08-28 Hossein Goodarzi Hosseinabadi

Electroanatomical mapping, a keystone diagnostic tool in cardiac electrophysiology studies, can provide high-density maps of the local electric properties of the tissue. It is therefore tempting to use such data to better individualize…

Optimization and Control · Mathematics 2021-02-03 Thomas Grandits , Simone Pezzuto , Jolijn M. Lubrecht , Thomas Pock , Gernot Plank , Rolf Krause

$\textbf{Purpose:}$ To develop a new method for free-breathing 3D extracellular volume (ECV) mapping of the whole heart at 3T. $\textbf{Methods:}$ A free-breathing 3D cardiac ECV mapping method was developed at 3T. T1 mapping was performed…

For plane-wave and many-spiral states of the experimentally based Luo-Rudy 1 model of heart tissue in large (8 cm square) domains, we show that an explicit space-time-adaptive time-integration algorithm can achieve an order of magnitude…

Computational Physics · Physics 2009-10-31 Elizabeth M. Cherry , Henry S. Greenside , Craig S. Henriquez

Calcification has significant influence over cardiovascular diseases and interventions. Detailed characterization of calcification is thus desired for predictive modeling, but calcified heart meshes for physics-driven simulations are still…

Computational Engineering, Finance, and Science · Computer Science 2024-03-11 Daniel H. Pak , Minliang Liu , Theodore Kim , Caglar Ozturk , Raymond McKay , Ellen T. Roche , Rudolph Gleason , James S. Duncan

The cardiovascular system is composed of the heart, blood and blood vessels. Regarding the heart, cardiac conditions are determined by the electrocardiogram, that is a noninvasive medical procedure. In this work, we propose autoregressive…

We present a novel hierarchical graphical model based context-aware hybrid brain-machine interface (hBMI) using probabilistic fusion of electroencephalographic (EEG) and electromyographic (EMG) activities. Based on experimental data…

Human-Computer Interaction · Computer Science 2018-09-18 Ozan Ozdenizci , Sezen Yagmur Gunay , Fernando Quivira , Deniz Erdogmus

Engineered heart tissues (EHTs) present a potential solution to some of the current challenges in the treatment of heart disease; however, the development of mature, adult-like cardiac tissues remains elusive. Mechanical stimuli have been…

Tissues and Organs · Quantitative Biology 2023-06-02 Javiera Jilberto , Samuel J. DePalma , Jason Lo , Hiba Kobeissi , Lani Quach , Emma Lejeune , Brendon M. Baker , David Nordsletten

The eikonal equation has become an indispensable tool for modeling cardiac electrical activation accurately and efficiently. In principle, by matching clinically recorded and eikonal-based electrocardiograms (ECGs), it is possible to build…

Optimization and Control · Mathematics 2023-12-06 Thomas Grandits , Jan Verhülsdonk , Gundolf Haase , Alexander Effland , Simone Pezzuto

Cardiac parametric mapping is useful for evaluating cardiac fibrosis and edema. Parametric mapping relies on single-shot heartbeat-by-heartbeat imaging, which is susceptible to intra-shot motion during the imaging window. However, reducing…

Image and Video Processing · Electrical Eng. & Systems 2025-03-25 Calder D. Sheagren , Brenden T. Kadota , Jaykumar H. Patel , Mark Chiew , Graham A. Wright

Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated…

In this paper it will be shown that according to the scheme theory in algebraic geometry, human heart as an elastic body can be represented as a 3D scheme, on account of algebraic equations of the myocardial fibers as the local parts of the…

Tissues and Organs · Quantitative Biology 2015-12-16 Saeed Ranjbar , Mersedeh Karvandi

Echocardiogram (echo) is the earliest and the primary tool for identifying regional wall motion abnormalities (RWMA) in order to diagnose myocardial infarction (MI) or commonly known as heart attack. This paper proposes a novel approach,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Serkan Kiranyaz , Aysen Degerli , Tahir Hamid , Rashid Mazhar , Rayyan Ahmed , Rayaan Abouhasera , Morteza Zabihi , Junaid Malik , Ridha Hamila , Moncef Gabbouj

Diffusion models have recently gained immense interest for their generative capabilities, specifically the high quality and diversity of the synthesized data. However, examples of their applications in 3D medical imaging are still scarce,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-21 Jolanta Mozyrska , Marcel Beetz , Luke Melas-Kyriazi , Vicente Grau , Abhirup Banerjee , Alfonso Bueno-Orovio

Electrical waves in the heart form rotating spiral or scroll waves during life-threatening arrhythmias such as atrial or ventricular fibrillation. The wave dynamics are typically modeled using coupled partial differential equations, which…

Medical Physics · Physics 2024-10-07 Tanish Baranwal , Jan Lebert , Jan Christoph

In this work, we present a computational fluid-structure interaction (FSI) study for a healthy patient-specific pulmonary arterial tree using the unified continuum and variational multiscale (VMS) formulation we previously developed. The…

Computational Physics · Physics 2020-08-19 Ju Liu , Weiguang Yang , Ingrid S. Lan , Alison L. Marsden

Cardiac arrhythmogenesis is governed by complex electromechanical interactions that are not directly observable in vivo, motivating the development of non-invasive computational approaches for reconstructing three-dimensional activation…

Medical Physics · Physics 2026-03-05 Nathan Dermul , Hans Dierckx

Recovering the 3D motion of the heart from cine cardiac magnetic resonance (CMR) imaging enables the assessment of regional myocardial function and is important for understanding and analyzing cardiovascular disease. However, 3D cardiac…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Qingjie Meng , Chen Qin , Wenjia Bai , Tianrui Liu , Antonio de Marvao , Declan P O'Regan , Daniel Rueckert

Monitoring the activity of the heart is important for diagnosing and preventing cardiovascular diseases. The electrocardiogram (ECG) is the gold standard for diagnosing such diseases. It monitors the heart's electrical activity, and while…

Signal Processing · Electrical Eng. & Systems 2023-09-19 Rémi Grisot , Pierre Laurent , Claire Migliaccio , Jean-Yves Dauvignac , Mélanie Brulc , Camille Chiquet , Jean-Paul Caruana

Reconstructing cardiac motion from CMR sequences is critical for diagnosis, prognosis, and intervention. Existing methods rely on complete CMR stacks to infer full heart motion, limiting their applicability during intervention when only…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Yihong Chen , Jiancheng Yang , Deniz Sayin Mercadier , Hieu Le , Juerg Schwitter , Pascal Fua