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Cardiac fibrillation is characterized by chaotic and disintegrated spiral wave dynamics patterns, whereas sinus rhythm shows synchronized excitation patterns. To determine functional correlations among cardiomyocytes during complex…

Tissues and Organs · Quantitative Biology 2022-10-20 Euijun Song

Cardiac magnetic resonance imaging (MRI) requires reconstructing a real-time video of a beating heart from continuous highly under-sampled measurements. This task is challenging since the object to be reconstructed (the heart) is…

Image and Video Processing · Electrical Eng. & Systems 2024-01-12 Johannes F. Kunz , Stefan Ruschke , Reinhard Heckel

Electrical analogy (Lumped method) is an easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that…

Medical Physics · Physics 2014-11-21 Omid Ghasemalizadeh , Mohammad Reza Mirzaee , Bahar Firoozabadi , Kamran Hassani

We numerically investigate the role of mechanical stress in modifying the conductivity properties of the cardiac tissue and its impact in computational models for cardiac electromechanics. We follow a theoretical framework recently proposed…

Tissues and Organs · Quantitative Biology 2019-05-02 A. Loppini , A. Gizzi , R. Ruiz Baier , C. Cherubini , F. Fenton , S. Filippi

Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. For this reason, many approaches have been developed to best estimate the cardiac muscle deformation, and to obtain a practical model to use in…

Computational Engineering, Finance, and Science · Computer Science 2014-12-09 Ahmadreza Baghaie , Hamid Abrishami Moghaddam

Accurate simulation of blood flow in deformable vessels is critical in cardiovascular research for understanding disease progression and informing clinical decision-making. However, due to the thin-walled nature of arteries, traditional…

Computational Engineering, Finance, and Science · Computer Science 2026-01-05 Chenxi Zhao , Dong Wu , Weiyi Kong , Oskar J. Haidn , Xiangyu Hu

In this study we present a novel computational model for unprecedented simulations of the whole cardiac electrophysiology. According to the heterogeneous electrophysiologic properties of the heart, the whole cardiac geometry is decomposed…

Medical Physics · Physics 2022-03-14 Giulio Del Corso , Roberto Verzicco , Francesco Viola

Fluid-structure interaction (FSI) modeling, a technique widely used to enhance imaging modalities for adult and pediatric heart diseases, has been underutilized in the context of fetal circulation because of limited data on flow conditions…

Medical Physics · Physics 2024-10-29 Zhenglun Alan Wei , Guihong Chen , Biao Si , Liqun Sun , Mike Seed , Shuping Ge

Multi-planar tagged MRI is the gold standard for regional heart wall motion evaluation. However, accurate recovery of the 3D true heart wall motion from a set of 2D apparent motion cues is challenging, due to incomplete sampling of the true…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Meng Ye , Bingyu Xin , Bangwei Guo , Leon Axel , Dimitris Metaxas

The efficient construction of anatomical models is one of the major challenges of patient-specific in-silico models of the human heart. Current methods frequently rely on linear statistical models, allowing no advanced topological changes,…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Jan Verhülsdonk , Thomas Grandits , Francisco Sahli Costabal , Thomas Pinetz , Rolf Krause , Angelo Auricchio , Gundolf Haase , Simone Pezzuto , Alexander Effland

We present a Lagrangian analysis of turbulent blood flow in the human left heart using high-fidelity simulations based on a patient-specific anatomical model. Leveraging a fully coupled fluid-structure-electrophysiology interaction (FSEI)…

Fluid Dynamics · Physics 2025-06-13 Fabio Guglietta , Martino Andrea Scarpolini , Francesco Viola , Luca Biferale

3D echocardiography is an increasingly popular tool for assessing cardiac remodelling in the right ventricle (RV). It allows quantification of the cardiac chambers without any geometric assumptions, which is the main weakness of 2D…

Image and Video Processing · Electrical Eng. & Systems 2021-04-07 Gabriel Bernardino , Amir Hodzic , Helene Langet , Damien LeGallois , Mathieu De Craene , Miguel Angel González Ballester , Eric Saloux , Bart Bijnens

Models of electrical excitation and recovery in the heart have become increasingly detailed, but have yet to be used routinely in the clinical setting to guide personalized intervention in patients. One of the main challenges is calibrating…

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

This paper aims at mathematically modeling a new multi-physics conductivity imaging system incorporating mechanical vibrations simultaneously applied to an imaging object together with current injections. We perturb the internal…

Medical Physics · Physics 2014-05-20 Habib Ammari , Eunjung Lee , Hyeuknam Kwon , Jin Keun Seo , Eung Je Woo

Elucidating the biomechanical behavior of the myocardium is crucial for understanding cardiac physiology, but cannot be directly inferred from clinical imaging and typically requires finite element (FE) simulations. However, conventional FE…

Medical Physics · Physics 2025-06-27 Siyu Mu , Wei Xuan Chan , Choon Hwai Yap

In this work, we investigated the effect of varying strength of Hyperkalemia and Hypoxia, in human cardiac tissue with a local ischemic subregion, on the electrical and mechanical activity of healthy and ischemic zones of the cardiac…

Numerical Analysis · Mathematics 2021-06-01 B. V. Rathish Kumar , Meena Pargaei , Luca F. Pavarino , Simone Scacchi

High-resolution and anatomically realistic computer models of biological soft tissues play a significant role in the understanding of the function of cardiovascular components in health and disease. However, the computational effort to…

Medical Physics · Physics 2015-08-12 Christoph M. Augustin , Gerhard A. Holzapfel , Olaf Steinbach

Reconstructing cardiac electrical activity from body surface electric potential measurements results in the severely ill-posed inverse problem in electrocardiography. Many different regularization approaches have been proposed to improve…

Numerical Analysis · Mathematics 2025-11-04 Manuel Haas , Thomas Grandits , Thomas Pinetz , Thomas Beiert , Simone Pezzuto , Alexander Effland

In the present paper, a new three-scale asymptotic homogenization method is proposed to study the electrical behavior of the cardiac tissue structure with multiple heterogeneities at two different levels. The first level is associated with…

Analysis of PDEs · Mathematics 2022-01-11 Fakhrielddine Bader , Mostafa Bendahmane , Mazen Saad , Raafat Talhouk
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