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Deep learning has driven significant advances in mitotic figure analysis within computational pathology. In this paper, we present our approach to the Mitosis Domain Generalization (MIDOG) 2025 Challenge, which consists of two distinct…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Shuting Xu , Runtong Liu , Zhixuan Chen , Junlin Hou , Hao Chen

Mitotic figure detection remains a challenging task in computational pathology due to domain variability and morphological complexity. This paper describes our participation in the MIDOG 2025 challenge, focusing on robust mitotic figure…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Euiseop Song , Jaeyoung Park , Jaewoo Park

Atypical mitotic figures are important biomarkers of tumor aggressiveness in histopathology, yet reliable recognition remains challenging due to severe class imbalance and variability across imaging domains. We present a DenseNet-121-based…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Adinath Dukre , Ankan Deria , Yutong Xie , Imran Razzak

Counting mitotic figures is time-intensive for pathologists and leads to inter-observer variability. Artificial intelligence (AI) promises a solution by automatically detecting mitotic figures while maintaining decision consistency.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-08 Seungho Choe , Xiaoli Qin , Abubakr Shafique , Amanda Dy , Susan Done , Dimitrios Androutsos , April Khademi

Mitotic figure detection in histopathology images remains challenging due to significant domain shifts across different scanners, staining protocols, and tissue types. This paper presents our approach for the MIDOG 2025 challenge Track 1,…

We tackle atypical versus normal mitosis classification in the MIDOG 2025 challenge using EfficientViT-L2, a hybrid CNN--ViT architecture optimized for accuracy and efficiency. A unified dataset of 13,938 nuclei from seven cancer types…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Xuan Qi , Dominic Labella , Thomas Sanford , Maxwell Lee

Motivation: Accurate classification of mitotic figures into normal and atypical types is crucial for tumor prognostication in digital pathology. However, developing robust deep learning models for this task is challenging due to the subtle…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Sujatha Kotte , Vangala Govindakrishnan Saipradeep , Vidushi Walia , Dhandapani Nandagopal , Thomas Joseph , Naveen Sivadasan , Bhagat Singh Lali

Recognizing atypical mitotic figures in histopathology images allows physicians to correctly assess tumor aggressiveness. Although machine learning models could be exploited for automatically performing such a task, under domain shift these…

Image and Video Processing · Electrical Eng. & Systems 2025-09-10 Gennaro Percannella , Mattia Sarno , Francesco Tortorella , Mario Vento

Counting of mitotic figures is a fundamental step in grading and prognostication of several cancers. However, manual mitosis counting is tedious and time-consuming. In addition, variation in the appearance of mitotic figures causes a high…

Computer Vision and Pattern Recognition · Computer Science 2023-09-26 Mostafa Jahanifar , Adam Shephard , Neda Zamanitajeddin , Simon Graham , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

This abstract presents our solution (Team Westwood) for mitosis detection and atypical mitosis classification in the MItosis DOmain Generalization (MIDOG) 2025 challenge. For mitosis detection, we trained an nnUNetV2 for initial mitosis…

Image and Video Processing · Electrical Eng. & Systems 2025-12-19 Tengyou Xu , Haochen Yang , Xiang 'Anthony' Chen , Hongyan Gu , Mohammad Haeri

Automated detection of mitotic figures in histopathology images is a challenging task: here, we present the different steps that describe the strategy we applied to participate in the MIDOG 2021 competition. The purpose of the competition…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Maxime W. Lafarge , Viktor H. Koelzer

This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Zhuoyan Shen , Esther Bär , Maria Hawkins , Konstantin Bräutigam , Charles-Antoine Collins-Fekete

The effective localization of mitosis is a critical precursory task for deciding tumor prognosis and grade. Automated mitosis detection through deep learning-oriented image analysis often fails on unseen patient data due to inherent domain…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Tirupati Saketh Chandr , Sahar Almahfouz Nasser , Nikhil Cherian Kurian , Amit Sethi

Mitotic figures represent a key histoprognostic feature in tumor pathology, providing crucial insights into tumor aggressiveness and proliferation. However, their identification remains challenging, subject to significant inter-observer…

Image and Video Processing · Electrical Eng. & Systems 2025-10-21 Raphaël Bourgade , Guillaume Balezo , Hana Feki , Lily Monier , Matthieu Blons , Alice Blondel , Delphine Loussouarn , Anne Vincent-Salomon , Thomas Walter

This work presents a mitosis detection method with only one vanilla Convolutional Neural Network (CNN). Our method consists of two steps: given an image, we first apply a CNN using a sliding window technique to extract patches that have…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Hongyan Gu , Mohammad Haeri , Shuo Ni , Christopher Kazu Williams , Neda Zarrin-Khameh , Shino Magaki , Xiang 'Anthony' Chen

Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Kaustubh Atey , Sameer Anand Jha , Gouranga Bala , Amit Sethi

The density of mitotic figures within tumor tissue is known to be highly correlated with tumor proliferation and thus is an important marker in tumor grading. Recognition of mitotic figures by pathologists is known to be subject to a strong…

Domain variability is a common bottle neck in developing generalisable algorithms for various medical applications. Motivated by the observation that the domain variability of the medical images is to some extent compact, we propose to…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Mustaffa Hussain , Ritesh Gangnani , Sasidhar Kadiyala

The detection of mitotic figures from different scanners/sites remains an important topic of research, owing to its potential in assisting clinicians with tumour grading. The MItosis DOmain Generalization (MIDOG) challenge aims to test the…

Computer Vision and Pattern Recognition · Computer Science 2021-09-30 Mostafa Jahanifar , Adam Shephard , Neda Zamani Tajeddin , R. M. Saad Bashir , Mohsin Bilal , Syed Ali Khurram , Fayyaz Minhas , Nasir Rajpoot

We present a novel approach which extends the existing Fully Convolutional One-Stage Object Detector (FCOS) for mitotic figure detection. Our composite model adds a Feedback Attention Ladder CNN (FAL-CNN) model for classification of normal…

Image and Video Processing · Electrical Eng. & Systems 2025-09-22 Andrew Broad , Jason Keighley , Lucy Godson , Alex Wright
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