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Transcranial ultrasonic stimulation (TUS) is rapidly gaining traction for non-invasive human neuromodulation, with a pressing need to establish protocols that maximise neuromodulatory efficacy. In this review, we aggregate and examine…

Biological Physics · Physics 2024-07-04 Tulika Nandi , Benjamin R. Kop , Kim Butts Pauly , Charlotte J. Stagg , Lennart Verhagen

Transcranial Electrical Stimulation (tES) is a neuromodulation technique that utilizes electrodes on the scalp to stimulate target brain regions. tES has shown promise in treating many neurological conditions, such as stroke rehabilitation…

Systems and Control · Electrical Eng. & Systems 2025-02-04 Chaitanya Goswami , Pulkit Grover

Non-invasive brain stimulation, such as transcranial alternating current stimulation (tACS) provides a powerful tool to directly modulate brain oscillations that mediate complex cognitive processes. While the body of evidence about the…

The primary motor cortex appears to be in the center of transcranial magnetic stimulation (TMS). It is one of few locations that provide directly observable responses, and its physiology serves as model or reference for almost all other TMS…

Neurons and Cognition · Quantitative Biology 2025-07-08 Maryam Farahmandrad , Stefan Goetz

Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel…

Performance · Computer Science 2020-06-25 Francesco Cremonesi , Georg Hager , Gerhard Wellein , Felix Schürmann

Background: Spinal cord injury (SCI) rehabilitation remains a major clinical challenge, with limited treatment options for functional recovery. Temporal interference (TI) electrical stimulation has emerged as a promising non-invasive…

Medical Physics · Physics 2025-03-07 Xu Xie , Yuchen Xu , Huilin Mou , Xi Li , Li Zhang , Zehao Sheng , Weidong Chen , Shaomin Zhang , Ruidong Cheng , Minmin Wang

Transcranial magnetic stimulation (TMS) is a noninvasive medical procedure that can modulate brain activity, and it is widely used in neuroscience and neurology research. Compared to manual operators, robots may improve the outcome of TMS…

In several diagnosis and therapy procedures based on electrostimulation effect, the internal physical quantity related to the stimulation is the induced electric field. To estimate the induced electric field in an individual human model,…

Medical Physics · Physics 2021-02-03 Essam A. Rashed , Jose Gomez-Tames , Akimasa Hirata

Objective: The objective of this study is to develop and evaluate a systematic approach to optimize Deep Brain Stimulation (DBS) parameters, addressing the challenge of identifying patient-specific settings and optimal stimulation targets…

Systems and Control · Electrical Eng. & Systems 2026-01-13 Anna Franziska Frigge , Lina Uggla , Elena Jiltsova , Markus Fahlström , Dag Nyholm , Alexander Medvedev

Objective. While ultrasound is largely established for use in diagnostic imaging and heating therapies, its application for neuromodulation is relatively new and not well understood. The objective of the present study was to investigate…

Tissues and Organs · Quantitative Biology 2015-03-09 Jerel K. Mueller , Wynn Legon , William J. Tyler

Generative models of brain activity have been instrumental in testing hypothesized mechanisms underlying brain dynamics against experimental datasets. Beyond capturing the key mechanisms underlying spontaneous brain dynamics, these models…

Neurons and Cognition · Quantitative Biology 2024-11-18 Rishikesan Maran , Eli J. Müller , Ben D. Fulcher

Music therapy has emerged recently as a successful intervention that improves patient's outcome in a large range of neurological and mood disorders without adverse effects. Brain networks are entrained to music in ways that can be explained…

Neurons and Cognition · Quantitative Biology 2023-05-25 Nicole Lai , Marios Philiastides , Fahim Kawsar , Fani Deligianni

Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency,…

Neurons and Cognition · Quantitative Biology 2019-07-15 Markus Schütt , Jens Christian Claussen

Background: Trans-spinal FUS (tsFUS) has recently been shown promise in modulating spinal reflexes in rodents, opening new avenues for spinal cord interventions in motor control and pain management. However, anatomical differences between…

Medical Physics · Physics 2025-07-09 Koharu Isomura , Wenwei Yu , Jose Gomez-Tames

Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data. Here, we discuss recent work using…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , Johan Nakuci , Sarah Feldt Muldoon

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

We present a real-time visualization system for Transcranial Magnetic Stimulation (TMS), a non-invasive neuromodulation technique for treating various brain disorders and mental health diseases. Our solution targets the current challenges…

Signal Processing · Electrical Eng. & Systems 2024-03-14 Loraine Franke , Tae Young Park , Jie Luo , Yogesh Rathi , Steve Pieper , Lipeng Ning , Daniel Haehn

Neuroprostheses show potential in restoring lost sensory function and enhancing human capabilities, but the sensations produced by current devices often seem unnatural or distorted. Exact placement of implants and differences in individual…

Neurons and Cognition · Quantitative Biology 2023-10-31 Jacob Granley , Tristan Fauvel , Matthew Chalk , Michael Beyeler

Low-intensity transcranial focused ultrasound (tFUS) is rapidly emerging as a transformative non-invasive brain stimulation (NIBS) modality characterized by high spatial resolution and ability to target deep brain circuits. Unlike…

Neurons and Cognition · Quantitative Biology 2026-04-02 William J. Tyler