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Imagine a world where clinical trials need far fewer patients to achieve the same statistical power, thanks to the knowledge encoded in large language models (LLMs). We present a novel framework for hierarchical Bayesian modeling of adverse…

Methodology · Statistics 2025-11-21 Shota Arai , David Selby , Andrew Vargo , Sebastian Vollmer

Bayesian inference for inverse problems hinges critically on the choice of priors. In the absence of specific prior information, population-level distributions can serve as effective priors for parameters of interest. With the advent of…

Instrumentation and Methods for Astrophysics · Physics 2025-02-11 Gabriel Missael Barco , Alexandre Adam , Connor Stone , Yashar Hezaveh , Laurence Perreault-Levasseur

Variational inference often struggles with the posterior geometry exhibited by complex hierarchical Bayesian models. Recent advances in flow-based variational families and Variationally Inferred Parameters (VIP) each address aspects of this…

Machine Learning · Computer Science 2025-11-06 Joohwan Ko , Justin Domke

Scale-mixture shrinkage priors have recently been shown to possess robust empirical performance and excellent theoretical properties such as model selection consistency and (near) minimax posterior contraction rates. In this paper, the…

Methodology · Statistics 2022-12-27 Ahmed Alhamzawi , Gorgees Shaheed Mohammad

Informed Markov chain Monte Carlo (MCMC) methods have been proposed as scalable solutions to Bayesian posterior computation on high-dimensional discrete state spaces, but theoretical results about their convergence behavior in general…

Computation · Statistics 2022-02-01 Quan Zhou , Aaron Smith

In recent years, pre-trained large language models (LLMs) have demonstrated remarkable efficiency in achieving an inference-time few-shot learning capability known as in-context learning. However, existing literature has highlighted the…

Computation and Language · Computer Science 2024-02-14 Xinyi Wang , Wanrong Zhu , Michael Saxon , Mark Steyvers , William Yang Wang

Covariance estimation and selection for multivariate datasets in a high-dimensional regime is a fundamental problem in modern statistics. Gaussian graphical models are a popular class of models used for this purpose. Current Bayesian…

Methodology · Statistics 2019-03-06 Xuan Cao , Shaojun Zhang

Multilevel models (MLMs) are a central building block of the Bayesian workflow. They enable joint, interpretable modeling of data across hierarchical levels and provide a fully probabilistic quantification of uncertainty. Despite their…

Bayesian estimation methods for sparse blind deconvolution problems conventionally employ Bernoulli-Gaussian (BG) prior for modeling sparse sequences and utilize Markov Chain Monte Carlo (MCMC) methods for the estimation of unknowns.…

Methodology · Statistics 2021-08-30 Burak Cevat Civek , Emre Ertin

Large Language Models (LLMs) have demonstrated great performance in few-shot In-Context Learning (ICL) for a variety of generative and discriminative chemical design tasks. The newly expanded context windows of LLMs can further improve ICL…

We introduce a new Bayesian multi-class support vector machine by formulating a pseudo-likelihood for a multi-class hinge loss in the form of a location-scale mixture of Gaussians. We derive a variational-inference-based training objective…

Machine Learning · Computer Science 2018-06-08 Martin Wistuba , Ambrish Rawat

Heavy-tailed continuous shrinkage priors, such as the horseshoe prior, are widely used for sparse estimation problems. However, there is limited work extending these priors to predictors with grouping structures. Of particular interest in…

Methodology · Statistics 2023-03-09 Jonathan Boss , Jyotishka Datta , Xin Wang , Sung Kyun Park , Jian Kang , Bhramar Mukherjee

In the variational relevance vector machine, the gamma distribution is representative as a hyperprior over the noise precision of automatic relevance determination prior. Instead of the gamma hyperprior, we propose to use the inverse gamma…

Machine Learning · Statistics 2020-05-08 Kazuaki. Murayama , Shuichi. Kawano

Multi-Modal Learning (MML) integrates information from diverse modalities to improve predictive accuracy. While existing optimization strategies have made significant strides by mitigating gradient direction conflicts, we revisit MML from a…

Machine Learning · Computer Science 2026-02-09 Peizheng Guo , Jingyao Wang , Wenwen Qiang , Jiahuan Zhou , Changwen Zheng , Gang Hua

The inferential model (IM) framework provides valid prior-free probabilistic inference by focusing on predicting unobserved auxiliary variables. But, efficient IM-based inference can be challenging when the auxiliary variable is of higher…

Statistics Theory · Mathematics 2015-01-20 Ryan Martin , Chuanhai Liu

Ill-posed linear inverse problems arise frequently in various applications, from computational photography to medical imaging. A recent line of research exploits Bayesian inference with informative priors to handle the ill-posedness of such…

Machine Learning · Statistics 2023-10-27 Gabriel Cardoso , Yazid Janati El Idrissi , Sylvain Le Corff , Eric Moulines

This paper develops a finite-sample statistical theory for in-context learning (ICL), analyzed within a meta-learning framework that accommodates mixtures of diverse task types. We introduce a principled risk decomposition that separates…

Machine Learning · Statistics 2025-12-09 Tomoya Wakayama , Taiji Suzuki

Integrative analyses based on statistically relevant associations between genomics and a wealth of intermediary phenotypes (such as imaging) provide vital insights into their clinical relevance in terms of the disease mechanisms. Estimates…

Applications · Statistics 2022-08-16 Snigdha Panigrahi , Shariq Mohammed , Arvind Rao , Veerabhadran Baladandayuthapani

The inverse Gaussian (IG) is one of the most famous and considered distributions with positive support. We propose a convenient mode-based parameterization yielding the reparametrized IG (rIG) distribution; it allows/simplifies the use of…

Methodology · Statistics 2017-07-17 Antonio Punzo

Large language models (LLMs) exhibit the ability to generalize given few-shot examples in their input prompt, an emergent capability known as in-context learning (ICL). We investigate whether LLMs use ICL to perform structured reasoning in…

Computation and Language · Computer Science 2025-07-01 Ritwik Gupta , Rodolfo Corona , Jiaxin Ge , Eric Wang , Dan Klein , Trevor Darrell , David M. Chan