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Matching patients effectively and efficiently for clinical trials is a significant challenge due to the complexity and variability of patient profiles and trial criteria. This paper introduces \textbf{Multi-Agent for Knowledge Augmentation…

Multiagent Systems · Computer Science 2026-05-19 Hanwen Shi , Jin Zhang , Kunpeng Zhang

Large language models (LLMs) typically operate in a question-answering paradigm, where the quality of the input prompt critically affects the response. Automated Prompt Optimization (APO) aims to overcome the cognitive biases of manually…

Computation and Language · Computer Science 2025-11-13 Jian Zhang , Zhangqi Wang , Haiping Zhu , Kangda Cheng , Kai He , Bo Li , Qika Lin , Jun Liu , Erik Cambria

While large language models are capable diagnostic tools, the impact of multi-agent topology on diagnostic accuracy remains underexplored. This study evaluates four agent topologies, Control (single agent), Hierarchical, Adversarial, and…

Multiagent Systems · Computer Science 2026-03-10 Ahmed Almasoud

Long-horizon tasks that require sustained reasoning and multiple tool interactions remain challenging for LLM agents: small errors compound across steps, and even state-of-the-art models often hallucinate or lose coherence. We identify…

Artificial Intelligence · Computer Science 2025-10-13 Guangya Wan , Mingyang Ling , Xiaoqi Ren , Rujun Han , Sheng Li , Zizhao Zhang

Multi-Agent Systems (MAS) with Large Language Model (LLM)-powered agents are gaining attention, yet fewer studies explore their team dynamics. Inspired by human team science, we propose a multi-agent framework to examine core aspects of…

Computation and Language · Computer Science 2025-10-13 Rasika Muralidharan , Haewoon Kwak , Jisun An

Medical diagnosis prediction plays a critical role in disease detection and personalized healthcare. While machine learning (ML) models have been widely adopted for this task, their reliance on supervised training limits their ability to…

Artificial Intelligence · Computer Science 2025-07-08 Yuzhang Xie , Hejie Cui , Ziyang Zhang , Jiaying Lu , Kai Shu , Fadi Nahab , Xiao Hu , Carl Yang

Multi-Agent Systems (MAS) powered by Large Language Models (LLMs) are emerging as a powerful paradigm for solving complex, multifaceted problems. However, the potential of these systems is often constrained by the prevalent plan-and-execute…

Artificial Intelligence · Computer Science 2025-07-18 Yexuan Shi , Mingyu Wang , Yunxiang Cao , Hongjie Lai , Junjian Lan , Xin Han , Yu Wang , Jie Geng , Zhenan Li , Zihao Xia , Xiang Chen , Chen Li , Jian Xu , Wenbo Duan , Yuanshuo Zhu

The remarkable progress in Large Language Models (LLMs) opens up new avenues for addressing planning and decision-making problems in Multi-Agent Systems (MAS). However, as the number of agents increases, the issues of hallucination in LLMs…

Artificial Intelligence · Computer Science 2024-01-24 Bin Zhang , Hangyu Mao , Jingqing Ruan , Ying Wen , Yang Li , Shao Zhang , Zhiwei Xu , Dapeng Li , Ziyue Li , Rui Zhao , Lijuan Li , Guoliang Fan

Large language models (LLMs) have demonstrated strong potential in clinical question answering, with recent multi-agent frameworks further improving diagnostic accuracy via collaborative reasoning. However, we identify a recurring issue of…

Computation and Language · Computer Science 2025-05-28 Yihan Wang , Qiao Yan , Zhenghao Xing , Lihao Liu , Junjun He , Chi-Wing Fu , Xiaowei Hu , Pheng-Ann Heng

Algorithmic problem solving serves as a rigorous testbed for evaluating structured reasoning in AI coding systems, as it directly reflects a model's ability to perform structured reasoning in complex scenarios. Existing approaches…

Artificial Intelligence · Computer Science 2026-05-11 Yuliang Xu , Xiang Xu , Yao Wan , Hu Wei , Tong Jia

Multi-Agent Systems (MASs) have been used to solve complex problems that demand intelligent agents working together to reach the desired goals. These Agents should effectively synchronize their individual behaviors so that they can act as a…

Robotics · Computer Science 2019-12-05 Marco A. C. Simões , Robson Marinho da Silva , Tatiane Nogueira

Multi-Agent Systems (MAS) built on Large Language Models (LLMs) often exhibit high variance in their reasoning trajectories. Process verification, which evaluates intermediate steps in trajectories, has shown promise in general reasoning…

Artificial Intelligence · Computer Science 2026-02-04 Vishal Venkataramani , Haizhou Shi , Zixuan Ke , Austin Xu , Xiaoxiao He , Yingbo Zhou , Semih Yavuz , Hao Wang , Shafiq Joty

Multi-agent systems (MAS) are increasingly used for open-ended idea generation, driven by the expectation that collective interaction will broaden the exploration diversity. However, when and why such collaboration truly expands the…

Multiagent Systems · Computer Science 2026-04-22 Nuo Chen , Yicheng Tong , Yuzhe Yang , Yufei He , Xueyi Zhang , Qingyun Zou , Qian Wang , Bingsheng He

The development of Large Language Models (LLMs) has catalyzed automation in customer service, yet benchmarking their performance remains challenging. Existing benchmarks predominantly rely on static paradigms and single-dimensional metrics,…

Artificial Intelligence · Computer Science 2026-04-13 Ling Shi , Yuqin Dai , Ziyin Wang , Ning Gao , Wei Zhang , Chaozheng Wang , Yujie Wang , Wei He , Jinpeng Wang , Deiyi Xiong

Multi-agent systems (MAS) leveraging the impressive capabilities of Large Language Models (LLMs) hold significant potential for tackling complex tasks. However, most current MAS depend on manually designed agent roles and communication…

Computation and Language · Computer Science 2026-03-10 Zixuan Ke , Austin Xu , Yifei Ming , Xuan-Phi Nguyen , Ryan Chin , Caiming Xiong , Shafiq Joty

Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

Computation and Language · Computer Science 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs,…

Computation and Language · Computer Science 2025-06-25 Yucheng Zhou , Lingran Song , Jianbing Shen

Large language model (LLM) systems are increasingly used to support high-stakes decision-making, but they typically perform worse when the available evidence is internally inconsistent. Such a scenario exists in real-world healthcare…

Computation and Language · Computer Science 2026-04-02 Haochen Liu , Weien Li , Rui Song , Zeyu Li , Chun Jason Xue , Xiao-Yang Liu , Sam Nallaperuma , Xue Liu , Ye Yuan

LLM-based multi-agent systems (MAS) have demonstrated significant potential in enhancing single LLMs to address complex and diverse tasks in practical applications. Despite considerable advancements, the field lacks a unified codebase that…

Large Language Model (LLM)-based agents have demonstrated strong capabilities across a wide range of tasks, and their application in the medical domain holds particular promise due to the demand for high generalizability and reliance on…

Artificial Intelligence · Computer Science 2025-08-18 Yangyang Zhuang , Wenjia Jiang , Jiayu Zhang , Ze Yang , Joey Tianyi Zhou , Chi Zhang
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