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Biomedical knowledge graphs (BKGs) have emerged as powerful tools for organizing and leveraging the vast and complex data found across the biomedical field. Yet, current reviews of BKGs often limit their scope to specific domains or…

Computation and Language · Computer Science 2025-01-23 Yuxing Lu , Sin Yee Goi , Xukai Zhao , Jinzhuo Wang

Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness between core biomedical concepts, enable…

Knowledge graphs are powerful tools for representing and organising complex biomedical data. Several knowledge graph embedding algorithms have been proposed to learn from and complete knowledge graphs. However, a recent study demonstrates…

Knowledge graphs (KGs) are a powerful approach for integrating heterogeneous data and making inferences in biology and many other domains, but a coherent solution for constructing, exchanging, and facilitating the downstream use of…

This comprehensive review aims to provide an overview of the current state of Healthcare Knowledge Graphs (HKGs), including their construction, utilization models, and applications across various healthcare and biomedical research domains.…

Biomedical knowledge graphs (KGs) hold rich information on entities such as diseases, drugs, and genes. Predicting missing links in these graphs can boost many important applications, such as drug design and repurposing. Recent work has…

Computation and Language · Computer Science 2021-09-22 Rahul Nadkarni , David Wadden , Iz Beltagy , Noah A. Smith , Hannaneh Hajishirzi , Tom Hope

Feature selection in Knowledge Graphs (KGs) are increasingly utilized in diverse domains, including biomedical research, Natural Language Processing (NLP), and personalized recommendation systems. This paper delves into the methodologies…

Machine Learning · Computer Science 2024-06-24 Sisi Shao , Pedro Henrique Ribeiro , Christina Ramirez , Jason H. Moore

Knowledge graphs (KGs) are widely used for representing and organizing structured knowledge in diverse domains. However, the creation and upkeep of KGs pose substantial challenges. Developing a KG demands extensive expertise in data…

Information Retrieval · Computer Science 2023-09-19 Samira Babalou , Sheeba Samuel , Birgitta König-Ries

Knowledge Graphs (KGs) have shown to be very important for applications such as personal assistants, question-answering systems, and search engines. Therefore, it is crucial to ensure their high quality. However, KGs inevitably contain…

Databases · Computer Science 2022-08-18 Elwin Huaman , Dieter Fensel

Drug discovery and development is a complex and costly process. Machine learning approaches are being investigated to help improve the effectiveness and speed of multiple stages of the drug discovery pipeline. Of these, those that use…

Artificial Intelligence · Computer Science 2022-09-27 Stephen Bonner , Ian P Barrett , Cheng Ye , Rowan Swiers , Ola Engkvist , Andreas Bender , Charles Tapley Hoyt , William L Hamilton

Knowledge graphs (KGs) have emerged as a powerful framework for representing and integrating complex biomedical information. However, assembling KGs from diverse sources remains a significant challenge in several aspects, including entity…

Machine Learning · Computer Science 2023-10-10 Yijia Xiao , Dylan Steinecke , Alexander Russell Pelletier , Yushi Bai , Peipei Ping , Wei Wang

Knowledge Graph Completion has been increasingly adopted as a useful method for helping address several tasks in biomedical research, such as drug repurposing or drug-target identification. To that end, a variety of datasets and Knowledge…

Machine Learning · Computer Science 2025-11-07 Alberto Cattaneo , Stephen Bonner , Thomas Martynec , Edward Morrissey , Carlo Luschi , Ian P Barrett , Daniel Justus

Knowledge graphs, collectively as a knowledge network, have become critical tools for knowledge discovery in computable and explainable knowledge systems. Due to the semantic and structural complexities of biomedical data, these knowledge…

Other Quantitative Biology · Quantitative Biology 2025-09-29 Chunlei Wu , Hongfang Liu , Jason Flannick , Mark A. Musen , Andrew I. Su , Lawrence Hunter , Thomas M. Powers , Cathy H. Wu

Knowledge Graphs (KGs) have been popularized during the last decade, for instance, they are used widely in the context of the web. In 2012 Google has presented the Google's Knowledge Graph that is used to improve their web search services.…

Databases · Computer Science 2022-08-17 Elwin Huaman

Much of biomedical and healthcare data is encoded in discrete, symbolic form such as text and medical codes. There is a wealth of expert-curated biomedical domain knowledge stored in knowledge bases and ontologies, but the lack of reliable…

Artificial Intelligence · Computer Science 2020-06-25 David Chang , Ivana Balazevic , Carl Allen , Daniel Chawla , Cynthia Brandt , Richard Andrew Taylor

The incorporation of data analytics in the healthcare industry has made significant progress, driven by the demand for efficient and effective big data analytics solutions. Knowledge graphs (KGs) have proven utility in this arena and are…

Artificial Intelligence · Computer Science 2022-07-11 Bilal Abu-Salih , Muhammad AL-Qurishi , Mohammed Alweshah , Mohammad AL-Smadi , Reem Alfayez , Heba Saadeh

Biomedical datasets are often modeled as knowledge graphs (KGs) because they capture the multi-relational, heterogeneous, and dynamic natures of biomedical systems. KG completion (KGC), can, therefore, help researchers make predictions to…

Artificial Intelligence · Computer Science 2023-07-18 Lauren Nicole DeLong , Ramon Fernández Mir , Zonglin Ji , Fiona Niamh Coulter Smith , Jacques D. Fleuriot

Knowledge graphs (KGs) are an important tool for representing complex relationships between entities in the biomedical domain. Several methods have been proposed for learning embeddings that can be used to predict new links in such graphs.…

Artificial Intelligence · Computer Science 2026-05-12 Daniel Daza , Dimitrios Alivanistos , Payal Mitra , Thom Pijnenburg , Michael Cochez , Paul Groth

Knowledge graphs (KGs) serve as powerful tools for organizing and representing structured knowledge. While their utility is widely recognized, challenges persist in their automation and completeness. Despite efforts in automation and the…

Artificial Intelligence · Computer Science 2024-05-07 Mutahira Khalid , Raihana Rahman , Asim Abbas , Sushama Kumari , Iram Wajahat , Syed Ahmad Chan Bukhari

With knowledge graphs (KGs) at the center of numerous applications such as recommender systems and question answering, the need for generalized pipelines to construct and continuously update such KGs is increasing. While the individual…

Artificial Intelligence · Computer Science 2024-09-05 Marvin Hofer , Daniel Obraczka , Alieh Saeedi , Hanna Köpcke , Erhard Rahm
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