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Reduced-order models (ROMs) allow for the simulation of blood flow in patient-specific vasculatures without the high computational cost and wait time associated with traditional computational fluid dynamics (CFD) models. Unfortunately, due…

Computational Engineering, Finance, and Science · Computer Science 2024-02-27 Natalia L. Rubio , Luca Pegolotti , Martin R. Pfaller , Eric F. Darve , Alison L. Marsden

Physics-based 0D reduced-order models provide computationally lightweight predictions of cardiovascular flows, resolving bulk hemodynamics in fractions of a second that would take days to solve using traditional 3D finite-element…

Computational Engineering, Finance, and Science · Computer Science 2026-04-03 Natalia L. Rubio , Eric F. Darve , Alison L. Marsden

Cardiovascular diseases are a leading cause of death in the world, driving the development of patient-specific and benchmark models for blood flow analysis. This chapter provides a theoretical overview of the main categories of Reduced…

Numerical Analysis · Mathematics 2025-10-21 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

Reduced order modeling (ROM) techniques are numerical methods that approximate the solution of parametric partial differential equation (PDE) by properly combining the high-fidelity solutions of the problem obtained for several…

Numerical Analysis · Mathematics 2023-08-08 M. Girfoglio , L. Scandurra , F. Ballarin , G. Infantino , F. Nicolò , A. Montalto , G. Rozza , R. Scrofani , M. Comisso , F. Musumeci

The main goal of this work is to develop a data-driven Reduced Order Model (ROM) strategy from high-fidelity simulation result data of a Full Order Model (FOM). The goal is to predict at lower computational cost the time evolution of…

Computational Engineering, Finance, and Science · Computer Science 2024-09-02 Azzeddine Tiba , Thibault Dairay , Florian de Vuyst , Iraj Mortazavi , Juan-Pedro Berro Ramirez

This paper deals with the development of a Reduced-Order Model (ROM) to investigate haemodynamics in cardiovascular applications. It employs the use of Proper Orthogonal Decomposition (POD) for the computation of the basis functions and the…

Numerical Analysis · Mathematics 2025-01-24 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

Cardio-mechanical models can be used to support clinical decision-making. Unfortunately, the substantial computational effort involved in many cardiac models hinders their application in the clinic, despite the fact that they may provide…

Computational Engineering, Finance, and Science · Computer Science 2026-05-19 Robin Willems , Peter Förster , Sebastian Schöps , Olaf van der Sluis , Clemens V. Verhoosel

We propose a new data-driven reduced order model (ROM) framework that centers around the hierarchical structure of the variational multiscale (VMS) methodology and utilizes data to increase the ROM accuracy at a modest computational cost.…

Numerical Analysis · Mathematics 2020-10-28 Changhong Mou , Birgul Koc , Omer San , Leo G. Rebholz , Traian Iliescu

This paper presents a projection-based reduced order modelling (ROM) framework for unsteady parametrized optimal control problems (OCP$_{(\mu)}$s) arising from cardiovascular (CV) applications. In real-life scenarios, accurately defining…

Model-free deep reinforcement learning (DRL) methods suffer from poor sample efficiency. To overcome this limitation, this work introduces an adaptive reduced-order-model (ROM)-based reinforcement learning framework for active flow control.…

Machine Learning · Computer Science 2026-04-08 Zesheng Yao , Zhen-Hua Wan , Canjun Yang , Qingchao Xia , Mengqi Zhang

The investigation of fluid-solid systems is very important in a lot of industrial processes. From a computational point of view, the simulation of such systems is very expensive, especially when a huge number of parametric configurations…

Reduced-order models (ROMs) are widely used in fluid engineering to enable rapid prediction of flow fields for parametric analysis, design optimization, and control applications. Proper orthogonal decomposition (POD) is commonly employed to…

Fluid Dynamics · Physics 2026-02-25 Yuto Nakamura , Shintaro Sato , Naofumi Ohnishi

Reduced-order models based on physics are a popular choice in cardiovascular modeling due to their efficiency, but they may experience reduced accuracy when working with anatomies that contain numerous junctions or pathological conditions.…

The complexity of the cardiovascular system needs to be accurately reproduced in order to promptly acknowledge health conditions; to this aim, advanced multifidelity and multiphysics numerical models are crucial. On one side, Full Order…

Simulating fluid flows in different virtual scenarios is of key importance in engineering applications. However, high-fidelity, full-order models relying, e.g., on the finite element method, are unaffordable whenever fluid flows must be…

Fluid Dynamics · Physics 2021-11-24 Stefania Fresca , Andrea Manzoni

We propose a data-driven filtered reduced order model (DDF-ROM) framework for the numerical simulation of fluid flows. The novel DDF-ROM framework consists of two steps: (i) In the first step, we use explicit ROM spatial filtering of the…

Fluid Dynamics · Physics 2017-09-14 X. Xie , M. Mohebujjaman , L. G. Rebholz , T. Iliescu

Predictive modeling of blood flow and pressure have numerous applications ranging from non-invasive assessment of functional significance of disease to planning invasive procedures. While several such predictive modeling techniques have…

We develop a Reduced Order Model (ROM) for a Large Eddy Simulation (LES) approach that combines a three-step algorithm called Evolve-Filter-Relax (EFR) with a computationally efficient finite volume method. The main novelty of our ROM lies…

Numerical Analysis · Mathematics 2021-07-28 Michele Girfoglio , Annalisa Quaini , Gianluigi Rozza

While data-driven techniques are powerful tools for reduced-order modeling of systems with chaotic dynamics, great potential remains for leveraging known physics (i.e. a full-order model (FOM)) to improve predictive capability. We develop a…

Machine Learning · Computer Science 2025-07-30 Alex Guo , Michael D. Graham
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