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We uncover anisotropic permeability in microfluidic deterministic lateral displacement (DLD) arrays. A DLD array can achieve high-resolution bimodal size-based separation of microparticles, including bioparticles, such as cells. For an…

Fluid Dynamics · Physics 2017-09-27 Rohan Vernekar , Timm Krüger , Kevin Loutherback , Keith Morton , David Inglis

Deterministic lateral displacement (DLD) devices separate micrometer-scale particles in solution based on their size using a laminar microfluidic flow in an array of obstacles. We investigate array geometries with rational row-shift…

The motion of flexible fibers through structured fluidic environments is ubiquitous in nature and industrial applications. Most often, their dynamics results from the complex interplay between internal elastic stresses, contact forces and…

Fluid Dynamics · Physics 2022-09-23 Ursy Makanga , Mohammadreza Sepahi , Camille Duprat , Blaise Delmotte

An electrokinetically-driven deterministic lateral displacement (e-DLD) device is proposed for the continuous, two-dimensional fractionation of suspensions in microfluidic platforms. The suspended species are driven through an array of…

Fluid Dynamics · Physics 2016-05-04 Srinivas Hanasoge , Raghavendra Devendra , Javier F. Diez , German Drazer

We present a simple solution to enhance the separation ability of deterministic lateral displacement (DLD) systems by expanding the two-dimensional nature of these devices and driving the particles into size-dependent, fully…

Soft Condensed Matter · Physics 2016-04-27 Siqi Du , German Drazer

The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based…

Fluid Dynamics · Physics 2014-04-15 Timothy J. Bowman , German Drazer , Joelle Frechette

Fiber suspensions flowing in structured media are encountered in many biological and industrial systems. Interactions between fibers and the transporting flow as well as fiber contact with obstacles can lead to complex dynamics. In this…

Fluid Dynamics · Physics 2024-03-06 Zhibo Li , Clément Bielinski , Anke Lindner , Olivia du Roure , Blaise Delmotte

Deterministic lateral displacement (DLD) is a high-resolution separation technique used in various fields. A fundamental challenge in DLD is ensuring uniform flow characteristics across channel, particularly near sidewalls where pillar…

Fluid Dynamics · Physics 2025-06-10 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan

Inspired by numerous lab on a chip, biomedical and bioengineering applications such as cell sorting, focusing, trapping, and filtering of particles, manipulation of micron sized particle trajectories has been of significant interest in the…

Fluid Dynamics · Physics 2026-03-18 Partha Kumar Das

Sorting elongated anisotropic particles, such as fibers, dispersed in suspensions poses significant challenges as they present two characteristic dimensions: length and diameter. Fibers in suspension usually align with the flow, leading to…

Soft Condensed Matter · Physics 2024-09-16 Justin Maddox , Alban Sauret

Deterministic lateral displacement (DLD) is a popular technique for size-based separation of particles. One of the challenges in design of DLD chips is to eliminate the disturbance of fluid flow patterns caused by channel sidewalls…

Fluid Dynamics · Physics 2025-03-25 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan

We use a macromodel of a flow-driven deterministic lateral displacement (DLD) microfluidic system to investigate conditions leading to size-separation of suspended particles. This model system can be easily reconfigured to establish an…

Fluid Dynamics · Physics 2016-04-27 Siqi Du , German Drazer

The macroscopic phenomenon of filtration is the separation between suspended and liquid phases and it takes place in natural environments (e.g. groundwater, soil, hyporheic zone) and industrial systems (e.g. filtration plants,…

The lack of a simple operable method for longitudinal dynamic self-assembly of particles in a microchannel is one of the main problems in applying this technology to a wide range of researches, such as biomedical engineering, material…

Fluid Dynamics · Physics 2019-11-26 Linbo Liu , Haoyan Xu , Haibo Xiu , Nan Xiang , Zhonghua Ni

Long, flexible fibers transported by a turbulent channel flow sample non-linear variations of the fluid velocity along their length. As the fibers tumble and collide with the boundaries, they bounce off with an impulse that propels them…

Fluid Dynamics · Physics 2023-04-20 Jeremie Bec , Christophe Brouzet , Christophe Henry

This work investigates the migration of spherical particles of different sizes in a centrifuge-driven deterministic lateral displacement (c-DLD) device. Specifically, we use a scaled-up model to study the motion of suspended particles…

Soft Condensed Matter · Physics 2016-04-27 Mingliang Jiang , Aaron D. Mazzeo , German Drazer

We investigate the migration of particles of different geometrical shapes and sizes in a scaled-up model of a gravity-driven deterministic lateral displacement (g-DLD) device. Specifically, particles move through a square array of…

Fluid Dynamics · Physics 2016-05-04 Mingliang Jiang , Kostyantyn Budzan , German Drazer

Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles and remains limited for…

Soft Condensed Matter · Physics 2024-06-03 Wei Chien , Zunmin Zhang , Gerhard Gompper , Dmitry A. Fedosov

Within microcentrifuge devices, a microfluidic vortex separates larger particles from a heterogeneous suspension using inertial migration, a phenomenon that causes particles to migrate across streamlines. The ability to selectively capture…

Fluid Dynamics · Physics 2023-03-14 Samuel Christensen , Marcus Roper

Transport properties of particles in confining geometries show very specific characteristics as lateral drift, oscillatory movement between lateral walls or the deformation of flexible fibers. These dynamics result from viscous friction…

Fluid Dynamics · Physics 2020-04-03 M. Bechert , J. Cappello , M. Daïeff , F. Gallaire , A. Lindner , C. Duprat
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