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Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer…
We investigate the motion of suspended particles past a single line of equally spaced cylindrical posts that is slanted with respect to the driving force. We show that such a one-dimensional array of posts can fractionate particles…
We solve a design optimization problem for deterministic lateral displacement (DLD) device to sort same-size biological cells by their deformability, in particular to sort red blood cells (RBCs) by their viscosity contrast between the fluid…
We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…
The phase behavior of hard rectangular rods with length L and diameter D is studied in a narrow slit-like pore using the Parsons-Lee density functional theory. Using the restricted orientation approximation, we find strong adsorption at the…
In conventional Deterministic Lateral Displacement (DLD), the migration behavior of a particle of specific size is determined by the critical diameter (Dc), which is predefined by the device's geometry. In contrast to the typical approach…
Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…
Swimming microbes, such as bacteria and algae, live in diverse habitats including soil, ocean and human body which are characterized by structural boundaries and heterogeneous fluid flows. Although much progress has been made in…
The acoustofluidic method holds great promise for manipulating microorganisms. When exposed to the steady vortex structures of acoustic streaming flow, these microorganisms exhibit intriguing dynamic behaviors, such as hydrodynamic trapping…
We develop a new method to isolate localized defects from extended vibrational modes in disordered solids. This method augments particle interactions with an artificial potential that acts as a high-pass filter: it preserves small-scale…
The transport of deformable particles through porous media underlies a wealth of applications ranging from filtration to oil recovery to the transport and spreading of biological agents. Using direct numerical simulations, we analyze the…
Microfluidic trapping arrays have proven to be efficient tools for various applications that require working at the single-cell level, such as cell-cell communication or fusion. Although several hydrodynamic trapping devices have already…
We investigate the trajectories of rigid fibers as they are transported in a pressure-driven flow, at low Reynolds number, in shallow Hele Shaw cells. The transverse confinement and the resulting viscous friction on these elongated objects,…
Particle-wall interactions play a crucially important role in various applications such as microfluidic devices for cell sorting, particle separation, entire class of hydrodynamic filtration and its derivatives, etc. Yet, accurate…
Recent progress in colloidal science has led to elaborate self-assembled structures whose complexity raises hopes for elaborating new materials. However, the throughputs are extremely low and consequently, the chance to produce materials of…
Efficient particle sorting in microfluidic systems is vital for advancements in biomedical diagnostics and industrial applications. This study numerically investigates particle migration and passive sorting in symmetric serpentine…
This article presents a novel computational model to study the selective filtering of biological hydrogels due to the surface charge and size of diffusing particles. It is the first model that includes the random 3D fiber orientation and…
We study the dynamics of asymmetric, deformable particles in oscillatory, linear shear flow. By simulating the motion of a dumbbell, a ring polymer, and a capsule we show that cross-stream migration occurs for asymmetric elastic particles…
We investigate the transport dynamics of elongated microparticles in microchannel flows. While smooth-walled channels preserve the dependence of particle trajectories on initial orientation and lateral position, we show that introducing…
In this paper, we describe the unification and extension of multiple kinematic theories on the advection of colloidal particles through periodic obstacle lattices of arbitrary geometry and infinitesimally small obstacle size. We focus…