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Accurate mitotic figure classification is crucial in computational pathology, as mitotic activity informs cancer grading and patient prognosis. Distinguishing atypical mitotic figures (AMFs), which indicate higher tumor aggressiveness, from…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Hana Feki , Alice Blondel , Thomas Walter

We present a solution for the MIDOG 2025 Challenge Track~2, addressing binary classification of normal mitotic figures (NMFs) versus atypical mitotic figures (AMFs). The approach leverages pathology-specific foundation model H-optimus-0,…

Atypical mitotic figures (AMFs) represent abnormal cell division associated with poor prognosis. Yet their detection remains difficult due to low prevalence, subtle morphology, and inter-observer variability. The MIDOG 2025 challenge…

Image and Video Processing · Electrical Eng. & Systems 2025-10-15 Guillaume Balezo , Hana Feki , Raphaël Bourgade , Lily Monnier , Matthieu Blons , Alice Blondel , Etienne Decencière , Albert Pla Planas , Thomas Walter

Motivation: Accurate classification of mitotic figures into normal and atypical types is crucial for tumor prognostication in digital pathology. However, developing robust deep learning models for this task is challenging due to the subtle…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Sujatha Kotte , Vangala Govindakrishnan Saipradeep , Vidushi Walia , Dhandapani Nandagopal , Thomas Joseph , Naveen Sivadasan , Bhagat Singh Lali

Deep learning has driven significant advances in mitotic figure analysis within computational pathology. In this paper, we present our approach to the Mitosis Domain Generalization (MIDOG) 2025 Challenge, which consists of two distinct…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Shuting Xu , Runtong Liu , Zhixuan Chen , Junlin Hou , Hao Chen

Atypical mitotic figures (AMFs) are clinically relevant indicators of abnormal cell division, yet their reliable detection remains challenging due to morphological ambiguity and scanner variability. In this work, we investigated three…

Image and Video Processing · Electrical Eng. & Systems 2025-09-08 Biwen Meng , Xi Long , Jingxin Liu

The MIDOG 2025 challenge extends prior work on mitotic figure detection by introducing a new Track 2 on atypical mitosis classification. This task aims to distinguish normal from atypical mitotic figures in histopathology images, a…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Leire Benito-Del-Valle , Pedro A. Moreno-Sánchez , Itziar Egusquiza , Itsaso Vitoria , Artzai Picón , Cristina López-Saratxaga , Adrian Galdran

Mitotic figures are classified into typical and atypical variants, with atypical counts correlating strongly with tumor aggressiveness. Accurate differentiation is therefore essential for patient prognostication and resource allocation, yet…

Image and Video Processing · Electrical Eng. & Systems 2025-09-19 Mieko Ochi , Bae Yuan

Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Kaustubh Atey , Sameer Anand Jha , Gouranga Bala , Amit Sethi

We tackle atypical versus normal mitosis classification in the MIDOG 2025 challenge using EfficientViT-L2, a hybrid CNN--ViT architecture optimized for accuracy and efficiency. A unified dataset of 13,938 nuclei from seven cancer types…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Xuan Qi , Dominic Labella , Thomas Sanford , Maxwell Lee

Mitotic figures (MFs) are relevant biomarkers in tumor grading. Differentiating atypical MFs (AMFs) from normal MFs (NMFs) remains difficult, as manual annotation is time-consuming and subjective. In this work an ensemble of ConvNeXtBase…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Sara Krauss , Ellena Spieß , Daniel Hieber , Frank Kramer , Johannes Schobel , Dominik Müller

Mitotic figure detection remains a challenging task in computational pathology due to domain variability and morphological complexity. This paper describes our participation in the MIDOG 2025 challenge, focusing on robust mitotic figure…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Euiseop Song , Jaeyoung Park , Jaewoo Park

Recognizing atypical mitotic figures in histopathology images allows physicians to correctly assess tumor aggressiveness. Although machine learning models could be exploited for automatically performing such a task, under domain shift these…

Image and Video Processing · Electrical Eng. & Systems 2025-09-10 Gennaro Percannella , Mattia Sarno , Francesco Tortorella , Mario Vento

This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Zhuoyan Shen , Esther Bär , Maria Hawkins , Konstantin Bräutigam , Charles-Antoine Collins-Fekete

Mitotic activity is key for the assessment of malignancy in many tumors. Moreover, it has been demonstrated that the proportion of abnormal mitosis to normal mitosis is of prognostic significance. Atypical mitotic figures (MF) can be…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Marc Aubreville , Jonathan Ganz , Jonas Ammeling , Taryn A. Donovan , Rutger H. J. Fick , Katharina Breininger , Christof A. Bertram

Mitotic figure detection in histopathology images remains challenging due to significant domain shifts across different scanners, staining protocols, and tissue types. This paper presents our approach for the MIDOG 2025 challenge Track 1,…

Mitotic figure (MF) detection in histopathology images is challenging due to large variations in slide scanners, staining protocols, tissue types, and the presence of artifacts. This paper presents a collection of training techniques - a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Christian Marzahl , Brian Napora

Atypical mitosis marks a deviation in the cell division process that has been shown be an independent prognostic marker for tumor malignancy. However, atypical mitosis classification remains challenging due to low prevalence, at times…

Automated detection of mitotic figures in histopathology images is a challenging task: here, we present the different steps that describe the strategy we applied to participate in the MIDOG 2021 competition. The purpose of the competition…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Maxime W. Lafarge , Viktor H. Koelzer

Atypical mitotic figures are important biomarkers of tumor aggressiveness in histopathology, yet reliable recognition remains challenging due to severe class imbalance and variability across imaging domains. We present a DenseNet-121-based…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Adinath Dukre , Ankan Deria , Yutong Xie , Imran Razzak
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