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High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images…

Computer Vision and Pattern Recognition · Computer Science 2023-06-13 Johan Fredin Haslum , Christos Matsoukas , Karl-Johan Leuchowius , Erik Müllers , Kevin Smith

Healthcare applications are inherently multimodal, benefiting greatly from the integration of diverse data sources. However, the modalities available in clinical settings can vary across different locations and patients. A key area that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Mohammed Amer , Mohamed A. Suliman , Tu Bui , Nuria Garcia , Serban Georgescu

Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

Genomics · Quantitative Biology 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

Existing Image-Text Sentiment Analysis (ITSA) methods may suffer from inconsistent intra-modal and inter-modal sentiment relationships. Therefore, we develop a method that balances before fusing to solve the issue of vision-language…

Multimedia · Computer Science 2026-02-25 Jiesheng Wu , Shengrong Li

Long-tailed semi-supervised learning poses a significant challenge in training models with limited labeled data exhibiting a long-tailed label distribution. Current state-of-the-art LTSSL approaches heavily rely on high-quality…

Machine Learning · Computer Science 2024-10-10 Zi-Hao Zhou , Siyuan Fang , Zi-Jing Zhou , Tong Wei , Yuanyu Wan , Min-Ling Zhang

The focus of this study is on Unsupervised Continual Learning (UCL), as it presents an alternative to Supervised Continual Learning which needs high-quality manual labeled data. The experiments under the UCL paradigm indicate a phenomenon…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Chen Cheng , Jingkuan Song , Xiaosu Zhu , Junchen Zhu , Lianli Gao , Hengtao Shen

Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data…

Machine Learning · Computer Science 2025-10-01 Ping Xu , Zhiyuan Ning , Meng Xiao , Guihai Feng , Xin Li , Yuanchun Zhou , Pengfei Wang

The burgeoning discipline of computational pathology shows promise in harnessing whole slide images (WSIs) to quantify morphological heterogeneity and develop objective prognostic modes for human cancers. However, progress is impeded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Chao Tu , Kun Huang , Jie Zhang , Qianjin Feng , Yu Zhang , Zhenyuan Ning

Influenced by breakthroughs in LLMs, single-cell foundation models are emerging. While these models show successful performance in cell type clustering, phenotype classification, and gene perturbation response prediction, it remains to be…

This paper presents SimCLR: a simple framework for contrastive learning of visual representations. We simplify recently proposed contrastive self-supervised learning algorithms without requiring specialized architectures or a memory bank.…

Machine Learning · Computer Science 2020-07-02 Ting Chen , Simon Kornblith , Mohammad Norouzi , Geoffrey Hinton

The open-world assumption in model development suggests that a model might lack sufficient information to adequately handle data that is entirely distinct or out of distribution (OOD). While deep learning methods have shown promising…

Machine Learning · Computer Science 2025-05-21 Achmad Ginanjar , Xue Li , Priyanka Singh , Wen Hua

Contrastive learning has achieved great success in self-supervised visual representation learning, but existing approaches mostly ignored spatial information which is often crucial for visual representation. This paper presents…

Computer Vision and Pattern Recognition · Computer Science 2020-11-20 Xinyue Huo , Lingxi Xie , Longhui Wei , Xiaopeng Zhang , Hao Li , Zijie Yang , Wengang Zhou , Houqiang Li , Qi Tian

Isologous diversification theory for cell differentiation is proposed, based on simulations of interacting cells with biochemical networks and cell division process following consumption of some chemicals. According to the simulations of…

adap-org · Physics 2008-02-03 Kunihiko Kaneko , Tetsuya Yomo

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines.…

Quantitative Methods · Quantitative Biology 2013-02-15 Anyou Wang

Accurate classification of histological subtypes of non-small cell lung cancer (NSCLC) is essential in the era of precision medicine, yet current invasive techniques are not always feasible and may lead to clinical complications. This study…

Image and Video Processing · Electrical Eng. & Systems 2025-04-30 Fatih Aksu , Fabrizia Gelardi , Arturo Chiti , Paolo Soda

The human cerebral cortex has many bumps and grooves called gyri and sulci. Even though there is a high inter-individual consistency for the main cortical folds, this is not the case when we examine the exact shapes and details of the…

Machine Learning · Computer Science 2024-02-01 Aymeric Gaudin , Louise Guillon , Clara Fischer , Arnaud Cachia , Denis Rivière , Jean-François Mangin , Joël Chavas

Semi-supervised learning is a sound measure to relieve the strict demand of abundant annotated datasets, especially for challenging multi-organ segmentation . However, most existing SSL methods predict pixels in a single image…

Computer Vision and Pattern Recognition · Computer Science 2024-05-09 Lu Wen , Zhenghao Feng , Yun Hou , Peng Wang , Xi Wu , Jiliu Zhou , Yan Wang

In-Context Learning (ICL) enhances the performance of large language models (LLMs) with demonstrations. However, obtaining these demonstrations primarily relies on manual effort. In most real-world scenarios, users are often unwilling or…

Computation and Language · Computer Science 2025-06-02 Jinglong Gao , Xiao Ding , Lingxiao Zou , Bing Qin , Ting Liu

Out-of-distribution (OOD) prediction remains a significant challenge in machine learning, particularly for tabular data where traditional methods often fail to generalize beyond their training distribution. This paper introduces Tabular…

Machine Learning · Computer Science 2025-05-21 Achmad Ginanjar , Xue Li , Priyanka Singh , Wen Hua

In-context Learning (ICL) empowers large language models (LLMs) to swiftly adapt to unseen tasks at inference-time by prefixing a few demonstration examples before queries. Despite its versatility, ICL incurs substantial computational and…

Machine Learning · Computer Science 2025-02-26 Zhuowei Li , Zihao Xu , Ligong Han , Yunhe Gao , Song Wen , Di Liu , Hao Wang , Dimitris N. Metaxas