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Vision-language foundation models (VLMs) show promise for diverse imaging tasks but often underperform on medical benchmarks. Prior efforts to improve performance include model finetuning, which requires large domain-specific datasets and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Arnav Singhvi , Vasiliki Bikia , Asad Aali , Akshay Chaudhari , Roxana Daneshjou

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Computation and Language · Computer Science 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

Prompt optimization is essential for enhancing the performance of Large Language Models (LLMs) in a range of Natural Language Processing (NLP) tasks, particularly in scenarios of few-shot learning where training examples are incorporated…

Computation and Language · Computer Science 2024-08-15 Dai Do , Quan Tran , Svetha Venkatesh , Hung Le

Large Language Models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation, enabling their widespread adoption across various domains. However, their susceptibility to prompt injection attacks…

Cryptography and Security · Computer Science 2025-05-05 Jinsheng Pan , Xiaogeng Liu , Chaowei Xiao

POI representation learning plays a crucial role in handling tasks related to user mobility data. Recent studies have shown that enriching POI representations with multimodal information can significantly enhance their task performance.…

Artificial Intelligence · Computer Science 2025-03-05 Jiawei Cheng , Jingyuan Wang , Yichuan Zhang , Jiahao Ji , Yuanshao Zhu , Zhibo Zhang , Xiangyu Zhao

Vision-language foundation models (VLMs) have shown great potential in feature transfer and generalization across a wide spectrum of medical-related downstream tasks. However, fine-tuning these models is resource-intensive due to their…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Ye Du , Nanxi Yu , Shujun Wang

Large Language Models (LLMs) have shown strong promise for mining Electronic Health Records (EHRs) by reasoning over longitudinal clinical information to capture context-rich patient trajectories. However, leveraging LLMs for structured…

Computation and Language · Computer Science 2026-04-21 Arya Hadizadeh Moghaddam , Drew Ross , Mohsen Nayebi Kerdabadi , Dongjie Wang , Zijun Yao

Large Language Models (LLMs) perform best with well-crafted prompts, yet prompt engineering remains manual, inconsistent, and inaccessible to non-experts. We introduce Promptomatix, an automatic prompt optimization framework that transforms…

Computation and Language · Computer Science 2025-07-28 Rithesh Murthy , Ming Zhu , Liangwei Yang , Jielin Qiu , Juntao Tan , Shelby Heinecke , Caiming Xiong , Silvio Savarese , Huan Wang

This paper explores the seamless integration of Generative AI (GenAI) and Evolutionary Algorithms (EAs) within the domain of large-scale multi-objective optimization. Focusing on the transformative role of Large Language Models (LLMs), our…

Neural and Evolutionary Computing · Computer Science 2024-05-14 Gaurav Singh , Kavitesh Kumar Bali

Aligning Large Language Models (LLMs) with high-stakes medical standards remains a significant challenge, primarily due to the dissonance between coarse-grained preference signals and the complex, multi-dimensional nature of clinical…

Artificial Intelligence · Computer Science 2026-04-10 He Geng , Yangmin Huang , Lixian Lai , Qianyun Du , Hui Chu , Zhiyang He , Jiaxue Hu , Xiaodong Tao

While Large Language Models (LLMs) are being quickly adapted to many domains, including healthcare, their strengths and pitfalls remain under-explored. In our study, we examine the effects of prompt engineering to guide Large Language…

Computation and Language · Computer Science 2024-09-04 Daniil Filienko , Yinzhou Wang , Caroline El Jazmi , Serena Xie , Trevor Cohen , Martine De Cock , Weichao Yuwen

Interactive medical questioning is essential in real-world clinical consultations, where physicians must actively gather information from patients. While medical Large Language Models (LLMs) have shown impressive capabilities in static…

Computation and Language · Computer Science 2025-08-20 Hongxin Ding , Baixiang Huang , Yue Fang , Weibin Liao , Xinke Jiang , Zheng Li , Junfeng Zhao , Yasha Wang

Large language models (LLMs) offer substantial promise for text classification in political science, yet their effectiveness often depends on high-quality prompts and exemplars. To address this, we introduce a three-stage framework that…

Computation and Language · Computer Science 2025-04-08 Menglin Liu , Ge Shi

The overwhelming amount of biomedical scientific texts calls for the development of effective language models able to tackle a wide range of biomedical natural language processing (NLP) tasks. The most recent dominant approaches are…

Computation and Language · Computer Science 2021-04-21 Giacomo Miolo , Giulio Mantoan , Carlotta Orsenigo

This study examines the effect of prompt engineering on the performance of Large Language Models (LLMs) in clinical note generation. We introduce an Automatic Prompt Optimization (APO) framework to refine initial prompts and compare the…

Computation and Language · Computer Science 2024-07-08 Zonghai Yao , Ahmed Jaafar , Beining Wang , Zhichao Yang , Hong Yu

Designing optimal prompts and reasoning processes for large language models (LLMs) on domain-specific tasks is both necessary and challenging in real-world applications. Determining how to integrate domain knowledge, enhance reasoning…

Artificial Intelligence · Computer Science 2025-10-27 Yang Zhao , Pu Wang , Hao Frank Yang

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

While mainstream vision-language models (VLMs) have advanced rapidly in understanding image level information, they still lack the ability to focus on specific areas designated by humans. Rather, they typically rely on large volumes of…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Kangyu Zhu , Ziyuan Qin , Huahui Yi , Zekun Jiang , Qicheng Lao , Shaoting Zhang , Kang Li

Molecular design involves an enormous and irregular search space, where traditional optimizers such as Bayesian optimization, genetic algorithms, and generative models struggle to leverage expert knowledge or handle complex feedback.…

Machine Learning · Computer Science 2025-12-09 Nian Ran , Yue Wang , Xiaoyuan Zhang , Zhongzheng Li , Qingsong Ran , Wenhao Li , Richard Allmendinger

Recently, advanced large language models (LLMs) have emerged at an increasingly rapid pace. However, when faced with complex problems, most users are often unable to provide accurate and effective prompts to interact with LLMs, thus…

Computation and Language · Computer Science 2026-04-17 Wenjin Liu , Haoran Luo , Xueyuan Lin , Haoming Liu , Tiesunlong Shen , Jiapu Wang , Rui Mao , Erik Cambria