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Large vision-language models are steadily gaining personalization capabilities at the cost of fine-tuning or data augmentation. We present two models for image generation using model-agnostic learning that align semantic priors with…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Aboli Marathe

Designing de novo 3D molecules with desirable properties remains a fundamental challenge in drug discovery and molecular engineering. While diffusion models have demonstrated remarkable capabilities in generating high-quality 3D molecular…

Machine Learning · Computer Science 2026-01-15 Lianghong Chen , Dongkyu Eugene Kim , Mike Domaratzki , Pingzhao Hu

By formulating data samples' formation as a Markov denoising process, diffusion models achieve state-of-the-art performances in a collection of tasks. Recently, many variants of diffusion models have been proposed to enable controlled…

Machine Learning · Computer Science 2023-04-17 Hengtong Zhang , Tingyang Xu

Diffusion models have emerged as powerful tools for 3D medical image generation, yet bridging the gap between standard training objectives and clinical relevance remains a challenge. This paper presents a method to enhance 3D diffusion…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Yueying Tian , Xudong Han , Meng Zhou , Rodrigo Aviles-Espinosa , Rupert Young , Philip Birch

Policy loss estimation remains a fundamental and long-standing challenge in reinforcement learning (RL) for diffusion language models (dLLMs). We introduce Reinforcement Learning from Denoising Feedback (RLDF), a novel training paradigm…

Computation and Language · Computer Science 2026-05-26 Qi He , Huan Chen , Ya Guo , Huijia Zhu , Yi R. Fung , Baojian Zhou

Denoising-based generative models, particularly diffusion and flow matching algorithms, have achieved remarkable success. However, aligning their output distributions with complex downstream objectives, such as human preferences,…

Machine Learning · Computer Science 2025-08-29 Luozhijie Jin , Zijie Qiu , Jie Liu , Zijie Diao , Lifeng Qiao , Ning Ding , Alex Lamb , Xipeng Qiu

This paper focuses on a critical challenge in robotics: translating text-driven human motions into executable actions for humanoid robots, enabling efficient and cost-effective learning of new behaviors. While existing text-to-motion…

Diffusion models are a class of flexible generative models trained with an approximation to the log-likelihood objective. However, most use cases of diffusion models are not concerned with likelihoods, but instead with downstream objectives…

Machine Learning · Computer Science 2024-01-08 Kevin Black , Michael Janner , Yilun Du , Ilya Kostrikov , Sergey Levine

Diffusion models excel at modeling complex data distributions, including those of images, proteins, and small molecules. However, in many cases, our goal is to model parts of the distribution that maximize certain properties: for example,…

Reinforcement learning (RL) has improved guided image generation with diffusion models by directly optimizing rewards that capture image quality, aesthetics, and instruction following capabilities. However, the resulting generative policies…

Computer Vision and Pattern Recognition · Computer Science 2024-06-25 Owen Oertell , Jonathan D. Chang , Yiyi Zhang , Kianté Brantley , Wen Sun

Reinforcement learning (RL) has been effective for post-training autoregressive (AR) language models, but extending these methods to diffusion language models (DLMs) is challenging due to intractable sequence-level likelihoods. Existing…

The task of deducing three-dimensional molecular configurations from their two-dimensional graph representations holds paramount importance in the fields of computational chemistry and pharmaceutical development. The rapid advancement of…

Biomolecules · Quantitative Biology 2025-01-09 Bobin Yang , Jie Deng , Zhenghan Chen , Ruoxue Wu

Reinforcement learning (RL) struggles to scale to large, combinatorial action spaces common in many real-world problems. This paper introduces a novel framework for training discrete diffusion models as highly effective policies in these…

Machine Learning · Computer Science 2026-05-21 Haitong Ma , Ofir Nabati , Aviv Rosenberg , Bo Dai , Oran Lang , Craig Boutilier , Na Li , Shie Mannor , Lior Shani , Guy Tenneholtz

This tutorial provides a comprehensive survey of methods for fine-tuning diffusion models to optimize downstream reward functions. While diffusion models are widely known to provide excellent generative modeling capability, practical…

Machine Learning · Computer Science 2024-07-19 Masatoshi Uehara , Yulai Zhao , Tommaso Biancalani , Sergey Levine

Fine-tuning foundation models via reinforcement learning (RL) has proven promising for aligning to downstream objectives. In the case of diffusion models (DMs), though RL training improves alignment from early timesteps, critical issues…

Machine Learning · Statistics 2024-10-14 Roberto Barceló , Cristóbal Alcázar , Felipe Tobar

Reinforcement learning from human feedback (RLHF), which aligns a diffusion model with input prompt, has become a crucial step in building reliable generative AI models. Most works in this area use a discrete-time formulation, which is…

Machine Learning · Computer Science 2025-08-25 Hanyang Zhao , Haoxian Chen , Ji Zhang , David D. Yao , Wenpin Tang

Recent advancements in generative models have sparked a significant interest within the machine learning community. Particularly, diffusion models have demonstrated remarkable capabilities in synthesizing images and speech. Studies such as…

Machine Learning · Computer Science 2024-11-19 Jingyi Chen , Ju-Seung Byun , Micha Elsner , Andrew Perrault

One of the key challenges that Reinforcement Learning (RL) faces is its limited capability to adapt to a change of data distribution caused by uncertainties. This challenge arises especially in RL systems using deep neural networks as…

Machine Learning · Computer Science 2025-06-17 Amornyos Horprasert , Esa Apriaskar , Xingyu Liu , Lanlan Su , Lyudmila S. Mihaylova

Diffusion models recently emerged as a powerful paradigm for recommender systems, offering state-of-the-art performance by modeling the generative process of user-item interactions. However, training such models from scratch is both…

Information Retrieval · Computer Science 2025-11-11 Yu Hou , Hua Li , Ha Young Kim , Won-Yong Shin

Reinforcement Learning from human feedback (RLHF) has been shown a promising direction for aligning generative models with human intent and has also been explored in recent works for alignment of diffusion generative models. In this work,…

Machine Learning · Computer Science 2024-09-16 Hanyang Zhao , Haoxian Chen , Ji Zhang , David D. Yao , Wenpin Tang
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