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Robustness to modeling errors and uncertainties remains a central challenge in reinforcement learning (RL). In this work, we address this challenge by leveraging diffusion models to train robust RL policies. Diffusion models have recently…

Machine Learning · Computer Science 2025-12-03 Daniele Foffano , Alessio Russo , Alexandre Proutiere

Generative models such as diffusion have been employed as world models in offline reinforcement learning to generate synthetic data for more effective learning. Existing work either generates diffusion models one-time prior to training or…

Machine Learning · Computer Science 2024-05-31 Zeyu Fang , Tian Lan

Offline reinforcement learning (RL) aims to learn optimal policies from offline datasets, where the parameterization of policies is crucial but often overlooked. Recently, Diffsuion-QL significantly boosts the performance of offline RL by…

Machine Learning · Computer Science 2023-10-27 Bingyi Kang , Xiao Ma , Chao Du , Tianyu Pang , Shuicheng Yan

Diffusion models have recently demonstrated exceptional performance in image generation task. However, existing image generation methods still significantly suffer from the dilemma of image reasoning, especially in logic-centered image…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Jiadong Pan , Zhiyuan Ma , Kaiyan Zhang , Ning Ding , Bowen Zhou

Machine learning has the potential to automate molecular design and drastically accelerate the discovery of new functional compounds. Towards this goal, generative models and reinforcement learning (RL) using string and graph…

Machine Learning · Computer Science 2022-02-02 Daniel Flam-Shepherd , Alexander Zhigalin , Alán Aspuru-Guzik

Reinforcement learning (RL) is a promising approach for solving robotic manipulation tasks. However, it is challenging to apply the RL algorithms directly in the real world. For one thing, RL is data-intensive and typically requires…

Reinforcement learning has been widely applied to diffusion and flow models for visual tasks such as text-to-image generation. However, these tasks remain challenging because diffusion models have intractable likelihoods, which creates a…

Machine Learning · Computer Science 2026-05-20 Jaemoo Choi , Yuchen Zhu , Wei Guo , Petr Molodyk , Bo Yuan , Jinbin Bai , Yi Xin , Molei Tao , Yongxin Chen

We study the task of generating profitable Non-Fungible Token (NFT) images from user-input texts. Recent advances in diffusion models have shown great potential for image generation. However, existing works can fall short in generating…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Huiguo He , Tianfu Wang , Huan Yang , Jianlong Fu , Nicholas Jing Yuan , Jian Yin , Hongyang Chao , Qi Zhang

This study presents a generative optimization framework that builds on a fine-tuned diffusion model and reward-directed sampling to generate high-performance engineering designs. The framework adopts a parametric representation of the…

Machine Learning · Computer Science 2025-08-05 Hadi Keramati , Patrick Kirchen , Mohammed Hannan , Rajeev K. Jaiman

Diffusion models typically employ static or heuristic classifier-free guidance (CFG) schedules, which often fail to adapt across timesteps and noise conditions. In this work, we introduce a quantum reinforcement learning (QRL) controller…

Quantum Physics · Physics 2025-09-18 Chi-Sheng Chen , En-Jui Kuo

Aligning generative diffusion models with human preferences via reinforcement learning (RL) is critical yet challenging. Most existing algorithms are often vulnerable to reward hacking, such as quality degradation, over-stylization, or…

We address the problem of fine-tuning diffusion models for reward-guided generation in biomolecular design. While diffusion models have proven highly effective in modeling complex, high-dimensional data distributions, real-world…

Generative models, particularly diffusion models, have achieved remarkable success in density estimation for multimodal data, drawing significant interest from the reinforcement learning (RL) community, especially in policy modeling in…

Machine Learning · Computer Science 2024-12-03 Jinouwen Zhang , Rongkun Xue , Yazhe Niu , Yun Chen , Jing Yang , Hongsheng Li , Yu Liu

Reinforcement learning from human feedback (RLHF) has proven effective in aligning large language models with human preferences, inspiring the development of reward-centric diffusion reinforcement learning (RDRL) to achieve similar…

Machine Learning · Computer Science 2026-03-24 Kwanyoung Kim , Byeongsu Sim

RNA inverse folding, designing sequences to form specific 3D structures, is critical for therapeutics, gene regulation, and synthetic biology. Current methods, focused on sequence recovery, struggle to address structural objectives like…

Machine Learning · Computer Science 2026-01-28 Qi Si , Xuyang Liu , Penglei Wang , Xin Guo , Yuan Qi , Yuan Cheng

Generative models have made significant progress in synthesizing visual content, including images, videos, and 3D/4D structures. However, they are typically trained with surrogate objectives such as likelihood or reconstruction loss, which…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Yuanzhi Liang , Yijie Fang , Ke Hao , Rui Li , Ziqi Ni , Ruijie Su , Chi Zhang

Predicting molecular conformations from molecular graphs is a fundamental problem in cheminformatics and drug discovery. Recently, significant progress has been achieved with machine learning approaches, especially with deep generative…

Machine Learning · Computer Science 2022-03-16 Minkai Xu , Lantao Yu , Yang Song , Chence Shi , Stefano Ermon , Jian Tang

Text-based image segmentation aims to delineate object boundaries within an image from text prompts, offering higher flexibility and broader application scope compared to traditional fixed-category segmentation tasks. Recent studies have…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Zishen Qu , Xuesong Li , Haijian Gu , Hongwei Kang , Quan Meng , Tianrui Niu , Xin Yang , Ruidong Pan

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes

Online reinforcement learning (RL) has been central to post-training language models, but its extension to diffusion models remains challenging due to intractable likelihoods. Recent works discretize the reverse sampling process to enable…

Machine Learning · Computer Science 2026-02-17 Kaiwen Zheng , Huayu Chen , Haotian Ye , Haoxiang Wang , Qinsheng Zhang , Kai Jiang , Hang Su , Stefano Ermon , Jun Zhu , Ming-Yu Liu