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Stochastic models of sequential mutation acquisition are widely used to quantify cancer and bacterial evolution. Across manifold scenarios, recurrent research questions are: how many cells are there with $n$ alterations, and how long will…

Populations and Evolution · Quantitative Biology 2023-07-07 Michael D. Nicholson , David Cheek , Tibor Antal

We consider species tree estimation under a standard stochastic model of gene tree evolution that incorporates incomplete lineage sorting (as modeled by a coalescent process) and gene duplication and loss (as modeled by a branching…

Probability · Mathematics 2020-07-15 Max Hill , Brandon Legried , Sebastien Roch

The coalescent is a foundational model of latent genealogical trees under neutral evolution, but suffers from intractable sampling probabilities. Methods for approximating these sampling probabilities either introduce bias or fail to scale…

Statistics Theory · Mathematics 2026-02-19 Martina Favero , Jere Koskela

Identifiability of evolutionary tree models has been a recent topic of discussion and some models have been shown to be non-identifiable. A coalescent-based rooted population tree model, originally proposed by Nielsen et al. 1998 [2], has…

Populations and Evolution · Quantitative Biology 2013-04-15 Arindam RoyChoudhury

The growth rate of cosmic structure is a powerful cosmological probe for extracting information on the gravitational interactions and dark energy. In the late time Universe, the growth rate becomes non-linear and is usually probed by…

Cosmology and Nongalactic Astrophysics · Physics 2018-11-07 Ixandra Achitouv , Yan-Chuan Cai

We introduce a low dimensional function of the site frequency spectrum that is tailor-made for distinguishing coalescent models with multiple mergers from Kingman coalescent models with population growth, and use this function to construct…

Populations and Evolution · Quantitative Biology 2019-08-13 Jere Koskela

Birth-death processes take place ubiquitously throughout the universe. In general, birth and death rates depend on the system size (corresponding to the number of products or customers undergoing the birth-death process) and thus vary every…

Physics and Society · Physics 2023-07-19 Seong Jun Park , M. Y. Choi

Birth-death processes form a natural class where ideas and results on large deviations can be tested. In this paper, we derive a large deviation principle under the assumption that the rate of a jump down (death) is growing asymptotically…

Probability · Mathematics 2023-08-21 N. D. Vvedenskaya , A. V. Logachov , Y. M. Suhov , A. A. Yambartsev

We introduce a broad class of spatial models to describe how spatially heterogeneous populations live, die, and reproduce. Individuals are represented by points of a point measure, whose birth and death rates can depend both on spatial…

Probability · Mathematics 2024-01-02 Alison M. Etheridge , Thomas G. Kurtz , Ian Letter , Peter L. Ralph , Terence Tsui Ho Lung

We consider the problem of estimating the elapsed time since the most recent common ancestor of a finite random sample drawn from a population which has evolved through a Bienayme-Galton-Watson branching process. More specifically, we are…

Populations and Evolution · Quantitative Biology 2019-09-04 Conrad J. Burden , Albert C. Soewongsono

The use of mathematical models to make predictions about tumor growth and response to treatment has become increasingly more prevalent in the clinical setting. The level of complexity within these models ranges broadly, and the calibration…

Quantitative Methods · Quantitative Biology 2021-12-28 Allison L. Lewis , Kathleen M. Storey , Heyrim Cho , Anna C. Zittle

Particle coarsening and grain growth take place to minimize the total interfacial energy. The classical mean-field treatments by Lifshitz, Slyozov, [1] Wagner [2] and Hillert [3] predicted cubic growth law under bulk-diffusion controlled…

Materials Science · Physics 2017-08-24 Yanhao Dong , Jian Han

In mathematical population genetics, it is well known that one can represent the genealogy of a population by a tree, which indicates how the ancestral lines of individuals in the population coalesce as they are traced back in time. As the…

Probability · Mathematics 2014-02-20 Götz Kersting , Jason Schweinsberg , Anton Wakolbinger

In the framework of the Statistical Multifragmentation Model, the nuclear isoscaling analysis is extended to constrain the ratio between the sizes of the decaying sources formed in a collision between two heavy ions. It is found that the…

Nuclear Theory · Physics 2022-07-05 S. R. Souza , R. Donangelo , W. G. Lynch , M. B. Tsang

We study a universal object for the genealogy of a sample in populations with mutations: the critical birth-death process with Poissonian mutations, conditioned on its population size at a fixed time horizon. We show how this process arises…

Probability · Mathematics 2014-07-30 G. Achaz , C. Delaporte , A. Lambert

Complex systems, in many different scientific sectors, show coarse-grain properties with simple growth laws with respect to fundamental microscopic algorithms. We propose a classification scheme of growth laws which includes human aging,…

Biological Physics · Physics 2012-07-17 P. Castorina , P. Blanchard

Consider a supercritical birth and death process where the children acquire mutations. We study the mutation rates along the ancestral lineages in a sample of size $n$ from the population at time $T$. The mutation rate is time-inhomogenous…

Probability · Mathematics 2024-02-27 Yubo Shuai

In this paper we study the iterated birth process of which we examine the first-passage time distributions and the hitting probabilities. Furthermore, linear birth processes, linear and sublinear death processes at Poisson times are…

Probability · Mathematics 2016-03-23 L. Beghin , E. Orsingher

We consider a general class of Markovian models describing the growth in a randomly fluctuating environment of a clonal biological population having several phenotypes related by stochastic switching. Phenotypes differ e.g. by the level of…

Populations and Evolution · Quantitative Biology 2022-01-25 J. Unterberger

We establish estimates for the coalescence time of semi-infinite directed geodesics in the planar corner growth model with i.i.d. exponential weights. There are four estimates: upper and lower bounds on the probabilities of both fast and…

Probability · Mathematics 2020-09-08 Timo Seppäläinen , Xiao Shen