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Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date…
Whispering-gallery-mode (WGM) microcavities have emerged as a promising alternative to traditional ultrasound probes, offering high sensitivity and wide bandwidth. In our research, we propose a novel silica WGM microprobe device, with…
Label-free biosensors, including conventional quartz-crystal-microbalance (QCM) biosensor, are seriously affected by nonspecific adsorption of contaminants involved in analyte solution, and it is exceptionally difficult to extract the…
Whispering gallery mode (WGM) microcavities feature ultrahigh Q-factors and small mode volumes, offering strong light-matter interactions for sensing applications. However, unmodified surfaces are weakly responsive togas-phase refractive…
Microcavity and whispering gallery mode (WGM) biosensors derive their sensitivity from monitoring frequency shifts induced by protein binding at sites of highly confined field intensities, where field strengths can be further amplified by…
Studies of biochemical liquids require precise determination of their complex permittivity. We developed a microwave characterization technique on the basis of a high-quality whispering-gallery mode (WGM) sapphire resonator with a…
Whispering gallery mode (WGM) microtoroid resonators are one of the most sensitive biochemical sensors in existence, capable of detecting single molecules. The main barrier for translating these devices out of the laboratory is that light…
Cellular membrane dynamics play an important role in a variety of physiological processes. However, due to the stringent light-coupling conditions required for exciting evanescent waves, label-free mapping of cellular membrane dynamics on…
Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive realtime observation of motor molecule motion. However, to date…
Accurate, label-free quantification of multiple analytes in complex biological media remains a major challenge due to limited multiplexing, signal cross-correlations, and inconsistency across sensor samples and measurement runs. We…
We present a wireless QCM biosensor fabricated using MEMS technology. The MEMS QCM biosensor contains a 125-MHz AT-cut quartz resonator embedded in the microchannel. Because of the compact design, the MEMS QCM biosensor is suitable for mass…
Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring and molecu-lar biology research, by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on…
Sensing with optical whispering gallery modes (WGMs) is a rapidly developing detection method in modern microfluidics research. This method explores the perturbations of spectra of WGMs propagating along the wall of an optical…
We develop a compact whispering-gallery-mode (WGM) sensing system by integrating multiple components, including a tunable laser, a temperature controller, a function generator, an oscilloscope, a photodiode detector, and a testing computer,…
A microfluidic whispering gallery mode (WGM) biosensing system is proposed for enhanced delivery and detection of target molecules. A microtoroid resonator coupled to a tapered optical fiber is immersed within a microfluidic channel, and…
Label-free biosensors are important tools for clinical diagnostics and for studying biology at the single molecule level. The development of optical label-free sensors has allowed extreme sensitivity, but can expose the biological sample to…
Spectroscopy is the basic tool for studying molecular physics and realizing bio-chemical sensing. However, it is challenging to realize sub-femtometer resolution spectroscopy over broad bandwidth. In this paper, broadband and…
In this study, an integrated low-cost and complexity mm-wave structure of Whispering Gallery Mode (WGM) is proposed for sensing the glucose levels in mimicking aquatic solutions of concentrations similar to type 2 diabetics. The bio-sensor…
Bacterial infectious diseases are a major threat to human health. Timely and sensitive pathogenic bacteria detection is crucial in identifying the bacterial contaminations and preventing the spread of infectious diseases. Due to limitations…
The terahertz (THz) spectral regime offers unique opportunities for next-generation biochemical sensing due to its non-destructive, label-free probing capability and strong sensitivity to molecular vibrations. However, conventional THz…