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We previously demonstrated near-field speckle scanning based x-ray imaging to be an easy-to-implement phase sensing method capable of providing both high sensitivity and high resolution. Yet, this performance combination could only be…

Medical Physics · Physics 2017-06-21 Sebastien Berujon , Eric Ziegler

To reduce the potential radiation risk, low-dose CT has attracted much attention. However, simply lowering the radiation dose will lead to significant deterioration of the image quality. In this paper, we propose a noise reduction method…

Medical Physics · Physics 2016-10-04 Hu Chen , Yi Zhang , Weihua Zhang , Peixi Liao , Ke Li , Jiliu Zhou , Ge Wang

Low-dose computed tomography (LDCT) is the current standard for lung cancer screening, yet its adoption and accessibility remain limited. Many regions lack LDCT infrastructure, and even among those screened, early-stage cancer detection…

Medical Physics · Physics 2025-11-03 Joyoni Dey , Hunter C. Meyer , Murtuza S. Taqi

X-ray interferometry provides valuable information in terms of attenuation, small-angle scatter, and differential phase contrast. This multi-modal contrast can aid in many clinical applications, such as lung diseases and breast cancer.…

Optics · Physics 2026-03-12 Murtuza S. Taqi , Joyoni Dey , Hunter C. Meyer

We present a new approach for retrieving dark-field, phase shift, and attenuation images from speckle-based X-ray imaging data. Speckle-based X-ray imaging (SBXI) exploits sample-induced alterations to a reference near-field speckle pattern…

Medical Physics · Physics 2025-12-18 Jayvan Liu , Samantha J. Alloo , Max Langer , Konstantin M. Pavlov

Light-sheet fluorescence microscopy (LSFM) is used to capture volume images of biological specimens. It offers high contrast deep inside densely fluorescence labelled samples, fast acquisition speed and minimal harmful effects on the…

Image and Video Processing · Electrical Eng. & Systems 2024-04-05 Niklas Rottmayer , Claudia Redenbach , Florian Fahrbach

We present a fast and simple technique to convert images into a radiance surface-based scene representation. Building on existing radiance volume reconstruction algorithms, we introduce a subtle yet impactful modification of the loss…

Ptychography, as a powerful lensless imaging method, has become a popular member of the coherent diffractive imaging family over decades of development. The ability to utilize low-dose X-rays and/or fast scans offers a big advantage in a…

Medical Physics · Physics 2024-06-14 Longlong Wu , Shinjae Yoo , Yong S. Chu , Xiaojing Huang , Ian K. Robinson

Soft X-ray tomography provides detailed structural insight into whole cells but is hindered by experimental artifacts such as the missing wedge and by limited availability of annotated datasets. We present SimAQ, a simulation pipeline that…

Quantitative Methods · Quantitative Biology 2026-05-21 Jacob Egebjerg , Daniel Wüstner

Low-dose computed tomography (CT) plays a significant role in reducing the radiation risk in clinical applications. However, lowering the radiation dose will significantly degrade the image quality. With the rapid development and wide…

Image and Video Processing · Electrical Eng. & Systems 2022-12-08 Bin Huang , Liu Zhang , Shiyu Lu , Boyu Lin , Weiwen Wu , Qiegen Liu

We present a method that lowers the dose required for a ptychographic reconstruction by adaptively scanning the specimen, thereby providing the required spatial information redundancy in the regions of highest importance. The proposed…

Computational Physics · Physics 2022-03-30 Marcel Schloz , Johannes Müller , Thomas C. Pekin , Wouter Van den Broek , Christoph T. Koch

We demonstrate dark-field x-ray microtomography in a compact, laboratory-based system capable of resolving attenuation, phase, and anisotropic scattering signals with micrometer-scale resolution across centimetre-scale samples. The method…

To take advantage of high-resolution optics sensitive to a broad energy range, future X-ray imaging instruments will require thick detectors with small pixels. This pixel aspect ratio affects spectral response in the soft X-ray band, vital…

In this work, a general theoretical framework is presented to explain the formation of the phase signal in an X-ray microscope integrated with a grating interferometer, which simultaneously enables the high spatial resolution imaging and…

Optics · Physics 2022-09-28 Jiecheng Yang , Yongshuai Ge , Dong Liang , Hairong Zheng

Electron and x-ray microscopes allow one to image the entire, unlabeled structure of hydrated materials at a resolution well beyond what visible light microscopes can achieve. However, both approaches involve ionizing radiation, so that…

Applied Physics · Physics 2020-04-22 Ming Du , Chris Jacobsen

Conventional x-ray imaging detectors suffer from parallax error when the radiation beam arrives at the detector surface at tilted angle. The image blurring occurs as the radiation penetrates detector material in lateral direction at tilted…

Instrumentation and Detectors · Physics 2019-10-04 Polad Shikhaliev , Nicola Tartoni

The current high-fidelity generation and high-precision detection of DeepFake images are at an arms race. We believe that producing DeepFakes that are highly realistic and 'detection evasive' can serve the ultimate goal of improving future…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 Yihao Huang , Felix Juefei-Xu , Qing Guo , Yang Liu , Geguang Pu

Talbot(-Lau) interferometric X-ray darkfield imaging has, over the past decade, gained substantial interest for its ability to provide insights into a sample's microstructure below the imaging resolution by means of ultra small angle…

Applied Physics · Physics 2021-02-01 Jonas Graetz , Andreas Balles , Randolf Hanke , Simon Zabler

Sparse-view computed tomography (CT) -- using a small number of projections for tomographic reconstruction -- enables much lower radiation dose to patients and accelerated data acquisition. The reconstructed images, however, suffer from…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Zilong Li , Chenglong Ma , Jie Chen , Junping Zhang , Hongming Shan

Ring artifacts in X-ray micro-CT images are one of the primary causes of concern in their accurate visual interpretation and quantitative analysis. The geometry of X-ray micro-CT scanners is similar to the medical CT machines, except the…

Image and Video Processing · Electrical Eng. & Systems 2024-02-12 Dhruvi Shah , Shruti Mehta , Ashish Agrawal , Shishir Purohit , Bhaskar Chaudhury
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