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Prediction of mRNA gene-expression profiles directly from routine whole-slide images (WSIs) using deep learning models could potentially offer cost-effective and widely accessible molecular phenotyping. While such WSI-based gene-expression…

Genomics · Quantitative Biology 2024-10-03 Fredrik K. Gustafsson , Mattias Rantalainen

Modern artificial intelligence works typically train the parameters of fixed-sized deep neural networks using gradient-based optimization techniques. Simple evolutionary algorithms have recently been shown to also be capable of optimizing…

Neural and Evolutionary Computing · Computer Science 2023-04-26 Maximilien Le Clei , Pierre Bellec

We introduce a new function-preserving transformation for efficient neural architecture search. This network transformation allows reusing previously trained networks and existing successful architectures that improves sample efficiency. We…

Machine Learning · Computer Science 2018-06-08 Han Cai , Jiacheng Yang , Weinan Zhang , Song Han , Yong Yu

The algebraic properties of flattenings and subflattenings provide direct methods for identifying edges in the true phylogeny -- and by extension the complete tree -- using pattern counts from a sequence alignment. The relatively small…

Populations and Evolution · Quantitative Biology 2022-05-06 Joshua Stevenson , Barbara Holland , Michael Charleston , Jeremy Sumner

The automation of neural architecture design has been a coveted alternative to human experts. Recent works have small search space, which is easier to optimize but has a limited upper bound of the optimal solution. Extra human design is…

Computer Vision and Pattern Recognition · Computer Science 2021-08-19 Yuanzheng Ci , Chen Lin , Ming Sun , Boyu Chen , Hongwen Zhang , Wanli Ouyang

Mathematical modeling is a powerful tool for describing, predicting, and understanding complex phenomena exhibited by real-world systems. However, identifying the equations that govern a system's dynamics from experimental data remains a…

Neural and Evolutionary Computing · Computer Science 2024-12-05 Omar Rodríguez-Abreo , José Luis Aragón , Mario Alan Quiroz-Juárez

One of the main obstacles of adopting digital pathology is the challenge of efficient processing of hyperdimensional digitized biopsy samples, called whole slide images (WSIs). Exploiting deep learning and introducing compact WSI…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Azam Asilian Bidgoli , Shahryar Rahnamayan , Taher Dehkharghanian , Abtin Riasatian , H. R. Tizhoosh

Deep Research systems based on web agents have shown strong potential in solving complex information-seeking tasks, yet their search efficiency remains underexplored. We observe that many state-of-the-art open-source web agents rely on long…

Artificial Intelligence · Computer Science 2026-05-11 Junjie Wang , Zequn Xie , Dan Yang , Jie Feng , Yue Shen , Duolin Sun , Meixiu Long , Yihan Jiao , Zhehao Tan , Jian Wang , Peng Wei , Jinjie Gu

Data-driven inference of the generative dynamics underlying a set of observed time series is of growing interest in machine learning and the natural sciences. In neuroscience, such methods promise to alleviate the need to handcraft models…

Machine Learning · Computer Science 2024-11-06 Eric Volkmann , Alena Brändle , Daniel Durstewitz , Georgia Koppe

Transformer based Large Language Models (LLMs) have recently reached state of the art performance in Natural Language Processing (NLP) and Computer Vision (CV) domains. LLMs use the Multi-Headed Self-Attention (MHSA) mechanism to capture…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-09-24 Zuoning Zhang , Dhruv Parikh , Youning Zhang , Viktor Prasanna

Neural networks have proven effective at solving difficult problems but designing their architectures can be challenging, even for image classification problems alone. Our goal is to minimize human participation, so we employ evolutionary…

Neural and Evolutionary Computing · Computer Science 2017-06-13 Esteban Real , Sherry Moore , Andrew Selle , Saurabh Saxena , Yutaka Leon Suematsu , Jie Tan , Quoc Le , Alex Kurakin

The choice of crossover and mutation strategies plays a crucial role in the searchability, convergence efficiency and precision of genetic algorithms. In this paper, a novel improved genetic algorithm is proposed by improving the crossover…

Neural and Evolutionary Computing · Computer Science 2022-10-12 Dingming Yang , Zeyu Yu , Hongqiang Yuan , Yanrong Cui

The problem of reconstructing and identifying intracellular protein signaling and biochemical networks is of critical importance in biology today. We sought to develop a mathematical approach to this problem using, as a test case, one of…

Data Analysis, Statistics and Probability · Physics 2012-06-15 D. Napoletani , T. Sauer , D. C. Struppa , E. Petricoin , L. Liotta

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

Populations and Evolution · Quantitative Biology 2022-07-27 Brandon Legried , Sebastien Roch

Executable software engineering data is valuable for training SWE agents, but scaling it remains difficult for two reasons: only a small fraction of real repository changes yield verifiable, high-signal task instances, and naively building…

Software Engineering · Computer Science 2026-03-24 Jiarong Liang , Zhiheng Lyu , Zijie Liu , Xiangchao Chen , Ping Nie , Kai Zou , Wenhu Chen

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

Recently, many evolutionary computation methods have been developed to solve the feature selection problem. However, the studies focused mainly on small-scale issues, resulting in stagnation issues in local optima and numerical instability…

Neural and Evolutionary Computing · Computer Science 2021-10-28 Xubin Wang , Yunhe Wang , Ka-Chun Wong , Xiangtao Li

This study presents constructions of the space-time Conservation Element and Solution Element (CESE) methods to accommodate adaptive unstructured quadrilateral meshes. Subsequently, a novel algorithm is devised to effectively manage the…

Fluid Dynamics · Physics 2025-03-10 Lisong Shi , Chaoxiong Zhang , Chih-Yung Wen

Diffusion models have achieved remarkable success in high-fidelity image generation but remain computationally demanding due to their multi-step denoising process and large model sizes. Although prior work improves efficiency either by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Zongfang Liu , Shengkun Tang , Zongliang Wu , Xin Yuan , Zhiqiang Shen

We explore efficient neural architecture search methods and show that a simple yet powerful evolutionary algorithm can discover new architectures with excellent performance. Our approach combines a novel hierarchical genetic representation…

Machine Learning · Computer Science 2018-02-26 Hanxiao Liu , Karen Simonyan , Oriol Vinyals , Chrisantha Fernando , Koray Kavukcuoglu
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