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Alzheimer's disease (AD) is characterized by complex and largely unknown progression dynamics affecting the brain's morphology. Although the disease evolution spans decades, to date we cannot rely on long-term data to model the pathological…

Applications · Statistics 2019-08-14 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

Imaging-derived phenotypes (IDPs) summarize multi-organ physiology but provide only static snapshots of diseases that evolve over time. In contrast, longitudinal electronic health records encode disease trajectories through temporal…

Information Retrieval · Computer Science 2026-05-13 Zian Wang , Lizhen Lan , Guangming Wang , Haosen Zhang , Minxuan Xu , Qing Li , Tianxing He , Mo Yang , Wenyue Mao , Yajing Zhang , Yan Li , Chengyan Wang

Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…

This article introduces a predictor-dependent joint modeling framework for network data obtained from multiple subjects over a shared set of nodes with spatial co-ordinates and spatially correlated nodal attributes. The framework is highly…

Longitudinal voice biomarkers provide a non-invasive source of information for monitoring Parkinson's disease progression, but their statistical analysis is difficult because repeated measurements from the same subject are correlated,…

Machine Learning · Statistics 2026-04-28 Ran Tong , Lanruo Wang , Tong Wang , Wei Yan

Accurate and interpretable gait analysis plays a crucial role in the early detection of Parkinsons disease (PD),yet most existing approaches remain limited by single-modality inputs, low robustness, and a lack of clinical transparency. This…

Computer Vision and Pattern Recognition · Computer Science 2025-12-05 Manar Alnaasan , Md Selim Sarowar , Sungho Kim

Recent results in coupled or temporal graphical models offer schemes for estimating the relationship structure between features when the data come from related (but distinct) longitudinal sources. A novel application of these ideas is for…

Machine Learning · Statistics 2017-11-22 Ronak Mehta , Hyunwoo J. Kim , Shulei Wang , Sterling C. Johnson , Ming Yuan , Vikas Singh

Parkinson's Disease (PD) affects millions globally, impacting movement. Prior research utilized deep learning for PD prediction, primarily focusing on medical images, neglecting the data's underlying manifold structure. This work proposes a…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Jun-En Ding , Chien-Chin Hsu , Feng Liu

This paper addresses the challenges of fault prediction and delayed response in distributed systems by proposing an intelligent prediction method based on temporal feature learning. The method takes multi-dimensional performance metric…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-28 Yang Wang , Wenxuan Zhu , Xuehui Quan , Heyi Wang , Chang Liu , Qiyuan Wu

Traditional model-based diagnosis relies on constructing explicit system models, a process that can be laborious and expertise-demanding. In this paper, we propose a novel framework that combines concepts of model-based diagnosis with deep…

Artificial Intelligence · Computer Science 2023-10-11 Jan Lukas Augustin , Oliver Niggemann

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

A novel framework is proposed for handling the complex task of modelling and analysis of longitudinal, multivariate, heterogeneous clinical data. This method uses temporal abstraction to convert the data into a more appropriate form for…

Machine Learning · Computer Science 2025-05-09 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Recent analyses combining advanced theoretical techniques and high-quality data from thousands of simultaneously recorded neurons provide strong support for the hypothesis that neural dynamics operate near the edge of instability across…

Neurons and Cognition · Quantitative Biology 2024-03-25 Rubén Calvo , Carles Martorell , Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…

Machine Learning · Computer Science 2025-10-21 Arianna Francesconi , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Valerio Guarrasi , Rosa Sicilia

A temporal graph can be considered as a stream of links, each of which represents an interaction between two nodes at a certain time. On temporal graphs, link prediction is a common task, which aims to answer whether the query link is true…

Artificial Intelligence · Computer Science 2024-02-13 Bingqing Liu , Xikun Huang

Spatial-temporal graph modeling is an important task to analyze the spatial relations and temporal trends of components in a system. Existing approaches mostly capture the spatial dependency on a fixed graph structure, assuming that the…

Machine Learning · Computer Science 2019-06-04 Zonghan Wu , Shirui Pan , Guodong Long , Jing Jiang , Chengqi Zhang

There has been a recent surge of interest in time series modeling using the Transformer architecture. However, forecasting multivariate time series with Transformer presents a unique challenge as it requires modeling both temporal…

Machine Learning · Computer Science 2025-07-04 Yu-Hsiang Lan , Eric K. Oermann

A particular challenge for disease progression modeling is the heterogeneity of a disease and its manifestations in the patients. Existing approaches often assume the presence of a single disease progression characteristics which is…

Machine Learning · Computer Science 2022-07-26 Taha Ceritli , Andrew P. Creagh , David A. Clifton

In recent years, single modality based gait recognition has been extensively explored in the analysis of medical images or other sensory data, and it is recognised that each of the established approaches has different strengths and…

Computer Vision and Pattern Recognition · Computer Science 2021-01-08 Aite Zhao , Jianbo Li , Junyu Dong , Lin Qi , Qianni Zhang , Ning Li , Xin Wang , Huiyu Zhou

Temporal graph classification plays a critical role in applications such as cybersecurity, brain connectivity analysis, social dynamics, and traffic monitoring. Despite its significance, this problem remains underexplored compared to…

Machine Learning · Computer Science 2025-11-26 Md. Joshem Uddin , Soham Changani , Baris Coskunuzer