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This work discusses the performance of a modern numerical scheme for fluid dynamical problems on modern high-performance computing architectures. Our code implements a spatial nodal discontinuous Galerkin scheme that we test up to an order…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-08 Filipp Sporykhin , Holger Homann

Large language models (LLMs) are changing the way researchers interact with code and data in scientific computing. While their ability to generate general-purpose code is well established, their effectiveness in producing scientifically…

Software Engineering · Computer Science 2026-05-25 Ethan Holbrook , Juan C. Verduzco , Alejandro Strachan

Spatial computing architectures promise a major stride in performance and energy efficiency over the traditional load/store devices currently employed in large scale computing systems. The adoption of high-level synthesis (HLS) from…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-11-24 Johannes de Fine Licht , Maciej Besta , Simon Meierhans , Torsten Hoefler

Recent years have witnessed the fast development of machine learning potentials (MLPs) and their widespread applications in chemistry, physics, and material science. By fitting discrete ab initio data faithfully to continuous and…

Chemical Physics · Physics 2025-05-13 Junfan Xia , Yaolong Zhang , Bin Jiang

In reinforcement learning (RL) research, simulations enable benchmarks between algorithms, as well as prototyping and hyper-parameter tuning of agents. In order to promote RL both in research and real-world applications, frameworks are…

Robotics · Computer Science 2022-12-05 Christian Bitter , Timo Thun , Tobias Meisen

General-purpose processor vendors have integrated customized accelerator in their products due to the widespread use of General Matrix-Matrix Multiplication (GEMM) kernels. However, it remains a challenge to further improve the…

Hardware Architecture · Computer Science 2024-05-01 Bingcai Sui , Junzhong Shen , Caixia Sun , Junhui Wang , Zhong Zheng , Wei Guo

The past year has witnessed the increasing popularity of Large Language Models (LLMs). Their unprecedented scale and associated high hardware cost have impeded their broader adoption, calling for efficient hardware designs. With the large…

Hardware Architecture · Computer Science 2023-12-07 Hengrui Zhang , August Ning , Rohan Prabhakar , David Wentzlaff

We present release 2.0 of the ALPS (Algorithms and Libraries for Physics Simulations) project, an open source software project to develop libraries and application programs for the simulation of strongly correlated quantum lattice models…

R has become a cornerstone of scientific and statistical computing due to its extensive package ecosystem, expressive syntax, and strong support for reproducible analysis. However, as data sizes and computational demands grow, native R…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-13 Xiran Zhang , Javier Conejero , Sameh Abdulah , Jorge Ejarque , Ying Sun , Rosa M. Badia , David E. Keyes , Marc G. Genton

The molecular dynamics simulation package GROMACS runs efficiently on a wide variety of hardware from commodity workstations to high performance computing clusters. Hardware features are well exploited with a combination of SIMD,…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-03-14 Carsten Kutzner , Szilárd Páll , Martin Fechner , Ansgar Esztermann , Bert L. de Groot , Helmut Grubmüller

Neural networks have become indispensable for a wide range of applications, but they suffer from high computational- and memory-requirements, requiring optimizations from the algorithmic description of the network to the hardware…

Signal Processing · Electrical Eng. & Systems 2020-05-05 Andreas Toftegaard Kristensen , Robert Giterman , Alexios Balatsoukas-Stimming , Andreas Burg

We discuss the state of art of Lattice Boltzmann (LB) computing, with special focus on prospective LB schemes capable of meeting the forthcoming Exascale challenge. After reviewing the basic notions of LB computing, we discuss current…

Computational Physics · Physics 2020-06-14 Sauro Succi , Giorgio Amati , Massimo Bernaschi , Giacomo Falcucci , Marco Lauricella , Andrea Montessori

Among the algorithms that are likely to play a major role in future exascale computing, the fast multipole method (FMM) appears as a rising star. Our previous recent work showed scaling of an FMM on GPU clusters, with problem sizes in the…

Numerical Analysis · Computer Science 2012-10-30 Rio Yokota , Lorena Barba

GROMACS is a de-facto standard for classical Molecular Dynamics (MD). The rise of AI-driven interatomic potentials that pursue near-quantum accuracy at MD throughput now poses a significant challenge: embedding neural-network inference into…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-09 Luca Pennati , Andong Hu , Ivy Peng , Lukas Müllender , Stefano Markidis

We present a foundation model for exascale molecular dynamics simulations by leveraging an E(3) equivariant network architecture (Allegro) and a set of large-scale organic and inorganic materials datasets merged by Total Energy Alignment…

We push the boundaries of electronic structure-based \textit{ab-initio} molecular dynamics (AIMD) beyond 100 million atoms. This scale is otherwise barely reachable with classical force-field methods or novel neural network and machine…

We have extended the Falkon lightweight task execution framework to make loosely coupled programming on petascale systems a practical and useful programming model. This work studies and measures the performance factors involved in applying…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-11-17 Ioan Raicu , Zhao Zhang , Mike Wilde , Ian Foster , Pete Beckman , Kamil Iskra , Ben Clifford

A range of computational biology software (GROMACS, AMBER, NAMD, LAMMPS, OpenMM, Psi4 and RELION) was benchmarked on a representative selection of HPC hardware, including AMD EPYC 7742 CPU nodes, NVIDIA V100 and AMD MI250X GPU nodes, and an…

The growing demand for efficient, high-performance processing in machine learning (ML) and image processing has made hardware accelerators, such as GPUs and Data Streaming Accelerators (DSAs), increasingly essential. These accelerators…

Hardware Architecture · Computer Science 2025-04-17 Qunyou Liu , Marina Zapater , David Atienza

Modern out-of-order processors have increased capacity to exploit instruction level parallelism (ILP) and memory level parallelism (MLP), e.g., by using wide superscalar pipelines and vector execution units, as well as deep buffers for…

Programming Languages · Computer Science 2018-07-05 Vladimir Kiriansky , Haoran Xu , Martin Rinard , Saman Amarasinghe