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Large Language Models (LLMs) have introduced a new era of proficiency in comprehending complex healthcare and biomedical topics. However, there is a noticeable lack of models in languages other than English and models that can interpret…

Computer Vision and Pattern Recognition · Computer Science 2023-11-02 Junling Liu , Ziming Wang , Qichen Ye , Dading Chong , Peilin Zhou , Yining Hua

Current medical AI systems are often limited to narrow applications, hindering widespread adoption. We present MedVersa, a generalist foundation model trained on tens of millions of compiled medical instances. MedVersa unlocks generalist…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Hong-Yu Zhou , Julián Nicolás Acosta , Subathra Adithan , Suvrankar Datta , Eric J. Topol , Pranav Rajpurkar

The trustworthiness of AI applications has been the subject of recent research and is also addressed in the EU's recently adopted AI Regulation. The currently emerging foundation models in the field of text, speech and image processing…

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Large Language Models (LLMs) are increasingly used for clinical decision support, where hallucinations and unsafe suggestions may pose direct risks to patient safety. These risks are hard to assess: subtle clinical errors are often missed…

Computation and Language · Computer Science 2026-05-14 Yinzhu Chen , Abdine Maiga , Hossein A. Rahmani , Emine Yilmaz

Vision-language models, while effective in general domains and showing strong performance in diverse multi-modal applications like visual question-answering (VQA), struggle to maintain the same level of effectiveness in more specialized…

Computation and Language · Computer Science 2024-04-26 Cuong Nhat Ha , Shima Asaadi , Sanjeev Kumar Karn , Oladimeji Farri , Tobias Heimann , Thomas Runkler

Medical data poses a daunting challenge for AI algorithms: it exists in many different modalities, experiences frequent distribution shifts, and suffers from a scarcity of examples and labels. Recent advances, including transformers and…

Health informatics research is characterized by diverse data modalities, rapid knowledge expansion, and the need to integrate insights across biomedical science, data analytics, and clinical practice. These characteristics make it…

Artificial Intelligence · Computer Science 2025-09-24 Yuxiao Cheng , Jinli Suo

Traditional AI methods often rely on task-specific model designs and training, which constrain both the scalability of model size and generalization across different tasks. Here, we introduce ChemFM, a large foundation model specifically…

Computational Engineering, Finance, and Science · Computer Science 2025-11-06 Feiyang Cai , Katelin Zacour , Tianyu Zhu , Tzuen-Rong Tzeng , Yongping Duan , Ling Liu , Srikanth Pilla , Gang Li , Feng Luo

While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain…

Medical question-answering (QA) is a critical task for evaluating how effectively large language models (LLMs) encode clinical knowledge and assessing their potential applications in medicine. Despite showing promise on multiple-choice…

Computation and Language · Computer Science 2025-03-06 Guangfu Guo , Kai Zhang , Bryan Hoo , Yujun Cai , Xiaoqian Lu , Nanyun Peng , Yiwei Wang

In this paper, we release a largest ever medical Question Answering (QA) dataset with 26 million QA pairs. We benchmark many existing approaches in our dataset in terms of both retrieval and generation. Experimental results show that the…

Computation and Language · Computer Science 2023-05-03 Jianquan Li , Xidong Wang , Xiangbo Wu , Zhiyi Zhang , Xiaolong Xu , Jie Fu , Prayag Tiwari , Xiang Wan , Benyou Wang

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

Computers and Society · Computer Science 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…

Ensuring the general efficacy and goodness for human beings from medical large language models (LLM) before real-world deployment is crucial. However, a widely accepted and accessible evaluation process for medical LLM, especially in the…

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Large language models (LLMs) have demonstrated impressive generative capabilities with the potential to innovate in medicine. However, the application of LLMs in real clinical settings remains challenging due to the lack of factual…

Computation and Language · Computer Science 2024-07-08 Rui Yang , Haoran Liu , Edison Marrese-Taylor , Qingcheng Zeng , Yu He Ke , Wanxin Li , Lechao Cheng , Qingyu Chen , James Caverlee , Yutaka Matsuo , Irene Li

The current generation of large language models (LLMs) is typically designed for broad, general-purpose applications, while domain-specific LLMs, especially in vertical fields like medicine, remain relatively scarce. In particular, the…

Q-matrices are a cornerstone of theory-driven assessment and learning analytics, making item demands and students' underlying knowledge components and misconceptions explicit and actionable. However, Q-matrices are typically crafted by…

Computers and Society · Computer Science 2026-04-21 Ying Zhang , Ningxi Cheng , Yizhu Gao , Hongmei Li , Lehong Shi , Nicholas Young , Geng Yuan , Xiaoming Zhai

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush
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