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Quantum annealing is a promising paradigm for building practical quantum computers. Compared to other approaches, quantum annealing technology has been scaled up to a larger number of qubits. On the other hand, deep learning has been…

Quantum Physics · Physics 2021-07-07 Michele Sasdelli , Tat-Jun Chin

With the advent of exascale computing, effective load balancing in massively parallel software applications is critically important for leveraging the full potential of high performance computing systems. Load balancing is the distribution…

Quantum Physics · Physics 2025-01-30 Omer Rathore , Alastair Basden , Nicholas Chancellor , Halim Kusumaatmaja

Protein folding is one of the age-old biological problems that refers to the mechanism of understanding and predicting how a protein's linear sequence of amino acids folds into its specific three dimensional structure.This structure is…

Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the…

Quantum Physics · Physics 2018-03-02 Richard Y. Li , Rosa Di Felice , Remo Rohs , Daniel A. Lidar

Steric clashes pose a challenge when exploring dense protein systems using conventional explicit-chain methods. A minimal example is a single lattice protein confined on a minimal grid, with no free sites. Finding its minimum energy is a…

Quantum Physics · Physics 2025-10-03 Anders Irbäck , Lucas Knuthson , Sandipan Mohanty

Although quantum computing hardware has evolved significantly in recent years, spurred by increasing industrial and government interest, the size limitation of current generation quantum computers remains an obstacle when applying these…

Quantum Physics · Physics 2020-01-20 Gideon Bass , Max Henderson , Joshua Heath , Joseph Dulny

Quantum annealing has shown significant potential as an approach to near-term quantum computing. Despite promising progress towards obtaining a quantum speedup, quantum annealers are limited by the need to embed problem instances within the…

Data Structures and Algorithms · Computer Science 2018-07-31 Alastair A. Abbott , Cristian S. Calude , Michael J. Dinneen , Richard Hua

While quantum computing proposes promising solutions to computational problems not accessible with classical approaches, due to current hardware constraints, most quantum algorithms are not yet capable of computing systems of practical…

Quantum annealing is a heuristic quantum optimization algorithm that can be used to solve combinatorial optimization problems. In recent years, advances in quantum technologies have enabled the development of small- and intermediate-scale…

Quantum Physics · Physics 2022-10-05 Sheir Yarkoni , Elena Raponi , Thomas Bäck , Sebastian Schmitt

Accurately predicting protein structures from amino acid sequences remains a fundamental challenge in computational biology, with profound implications for understanding biological functions and enabling structure-based drug discovery.…

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

We explore the applicability of quantum annealing to the approximation task of curve fitting. To this end, we consider a function that shall approximate a given set of data points and is written as a finite linear combination of…

Optimization and Control · Mathematics 2026-02-27 Philipp Isserstedt , Daniel Jaroszewski , Wolfgang Mergenthaler , Felix Paul , Bastian Harrach

A reduced model, which can fold both helix and sheet structures, is proposed to study the problem of protein folding. The goal of this model is to find an unbiased effective potential that has included the effects of water and at the same…

Soft Condensed Matter · Physics 2007-05-23 Nan-yow Chen

Cybersecurity in telecommunication networks often leads to hard combinatorial optimization problems that are challenging to solve with classical methods. This work investigates the practical feasibility of using quantum annealing to address…

Quantum Physics · Physics 2026-01-05 Ali Abbassi , Yann Dujardin , Eric Gourdin , Philippe Lacomme , Caroline Prodhon

Quantum annealing may provide advantages over simulated annealing on solving some problems such as Kth order binary optimization problem. No feasible architecture exists to implement the high-order optimization problem (K > 2) on current…

Quantum Physics · Physics 2016-05-13 Yong-Chao Tang , Guo-Xing Miao

With the increasing popularity of quantum computing and in particular quantum annealing, there has been growing research to evaluate the meta-heuristic for various problems in linear algebra: from linear least squares to matrix and tensor…

Quantum Physics · Physics 2024-10-28 Ajinkya Borle , Samuel J. Lomonaco

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their…

Quantum Physics · Physics 2016-05-31 Itay Hen , Federico M. Spedalieri

There have been multiple attempts to demonstrate that quantum annealing and, in particular, quantum annealing on quantum annealing machines, has the potential to outperform current classical optimization algorithms implemented on CMOS…

RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into specific, stable structures that substantially govern their biochemical behaviour. Experimental characterization of these structures remains difficult,…

Quantum Physics · Physics 2023-05-02 Tristan Zaborniak , Juan Giraldo , Hausi Müller , Hosna Jabbari , Ulrike Stege

In this paper, we review some features of quantum annealing and related topics from viewpoints of statistical physics, condensed matter physics, and computational physics. We can obtain a better solution of optimization problems in many…

Disordered Systems and Neural Networks · Physics 2017-08-23 Shu Tanaka , Ryo Tamura