Related papers: In Silico Evaluation of Cardiac Tissue-Engineered …
Modeling the behavior of biological tissues and organs often necessitates the knowledge of their shape in the absence of external loads. However, when their geometry is acquired in-vivo through imaging techniques, bodies are typically…
Global single-valued biomarkers of cardiac function typically used in clinical practice, such as ejection fraction, provide limited insight on the true 3D cardiac deformation process and hence, limit the understanding of both healthy and…
Finite element (FE) simulations emulating transcatheter pulmonary valve (TPV) system deployment in patient-specific right ventricular outflow tracts (RVOT) assume material properties for the RVOT and adjacent tissues. Sensitivity of the…
Metastructured auxetic patches, characterized by negative Poisson's ratios, offer unique mechanical properties that closely resemble the behavior of human tissues and organs. As a result, these patches have gained significant attention for…
Finite element analysis (FEA) forms the cornerstone of modeling cardiac biomechanics but is computationally expensive, limiting its clinical application for digital twin creation, which often requires tens to hundreds of simulations to…
Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function and to improve diagnosis and therapy planning. However, in…
The analysis of plaque deposits in the coronary vasculature is an important topic in current clinical research. From a technical side mostly new algorithms for different sub tasks - e.g. centerline extraction or vessel/plaque segmentation -…
Myocardial infarction and heart failure are major cardiovascular diseases that affect millions of people in the US. The morbidity and mortality are highest among patients who develop cardiogenic shock. Early recognition of cardiogenic shock…
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of…
Ischemia leading to heart attacks and strokes is the major cause of deaths in the world. Whether an occlusion occurs or not, depends on the ability of a growing thrombus to resist forces exerted on its structure. This manuscript provides…
When modelling tissue-level cardiac electrophysiology, continuum approximations to the discrete cell-level equations are used to maintain computational tractability. One of the most commonly used models is represented by the bidomain…
Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…
Cardiac action potential models allow examination of a variety of cardiac dynamics, including how behavior may change under specific interventions. To study a specific scenario, including patient-specific cases, model parameter sets must be…
The mechanical response of interpenetrating phase composites (IPCs) with stochastic spinodal topologies is investigated experimentally and numerically. Model polymeric systems are fabricated by Polyjet multi-material printing, with the…
The amount of fat on the surroundings of the heart is correlated to several health risk factors such as carotid stiffness, coronary artery calcification, atrial fibrillation, atherosclerosis, cancer incidence and others. Furthermore, the…
Image-based computer simulation of cardiac function can be used to probe the mechanisms of (patho)physiology, and guide diagnosis and personalized treatment of cardiac diseases. This paradigm requires constructing simulation-ready meshes of…
Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. Many approaches have been developed to better estimate the cardiac muscle deformation, and to obtain a practical model to be used in diagnostic…
The occurrence of in-stent restenosis following percutaneous coronary intervention highlights the need for the creation of computational tools that can extract pathophysiological insights and optimize interventional procedures on a…
Scaffolds have a key role in the clinical success of tissue engineering for the regeneration of damaged tissues. Their bio-performance is often described as the extent to which they can provide an extracellular matrix-like environment for…
Extensive studies suggested that fluid mechanical markers of intracranial aneurysms (IAs) derived from Computational Fluid Dynamics (CFD) can indicate disease progression risks, but to date this has not been translated clinically. This is…