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Alzheimer's disease (AD) constitutes a complex neurocognitive disease and is the main cause of dementia. Although many studies have been proposed targeting at diagnosing dementia through spontaneous speech, there are still limitations.…

Deep learning has advanced medical image classification, but interpretability challenges hinder its clinical adoption. This study enhances interpretability in Chest X-ray (CXR) classification by using concept bottleneck models (CBMs) and a…

Concept Bottleneck Models (CBMs) tackle the opacity of neural architectures by constructing and explaining their predictions using a set of high-level concepts. A special property of these models is that they permit concept interventions,…

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text…

Concept Bottleneck Models (CBMs) provide a basis for semantic abstractions within a neural network architecture. Such models have primarily been seen through the lens of interpretability so far, wherein they offer transparency by inferring…

The main challenges hindering the adoption of deep learning-based systems in clinical settings are the scarcity of annotated data and the lack of interpretability and trust in these systems. Concept Bottleneck Models (CBMs) offer inherent…

Concept bottleneck models (CBMs) are a class of interpretable neural network models that predict the target response of a given input based on its high-level concepts. Unlike the standard end-to-end models, CBMs enable domain experts to…

We introduce the Concept Bottleneck Large Language Model (CB-LLM), a pioneering approach to creating inherently interpretable Large Language Models (LLMs). Unlike traditional black-box LLMs that rely on post-hoc interpretation methods with…

Large language models (LLMs) are increasingly being used in a zero-shot fashion to assess mental health conditions, yet we have limited knowledge on what factors affect their accuracy. In this study, we utilize a clinical dataset of natural…

The growing prevalence and complexity of mental health disorders present significant challenges for accurate diagnosis and treatment, particularly in understanding the interplay between co-occurring conditions. Mental health disorders, such…

Concept bottleneck models (CBMs) improve neural network interpretability by introducing an intermediate layer that maps human-understandable concepts to predictions. Recent work has explored the use of vision-language models (VLMs) to…

Concept bottleneck models (CBMs) are inherently interpretable models that make predictions based on human-understandable visual cues, referred to as concepts. As obtaining dense concept annotations with human labeling is demanding and…

The Concept Bottleneck Models (CBMs) of Koh et al. [2020] provide a means to ensure that a neural network based classifier bases its predictions solely on human understandable concepts. The concept labels, or rationales as we refer to them,…

Concept Bottleneck Models (CBMs) first map raw input(s) to a vector of human-defined concepts, before using this vector to predict a final classification. We might therefore expect CBMs capable of predicting concepts based on distinct…

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Concept Bottleneck Models (CBMs) aim to enhance interpretability by predicting human-understandable concepts as intermediates for decision-making. However, these models often face challenges in ensuring reliable concept representations,…

Objective: Large Language Models (LLMs) demonstrate significant capabilities in medical text understanding and generation. However, their diagnostic reliability in complex clinical scenarios remains limited. This study aims to enhance LLMs'…

In this work, we utilize Machine Learning for early recognition of patients at high risk of acute respiratory distress syndrome (ARDS), which is critical for successful prevention strategies for this devastating syndrome. The difficulty in…

Timely identification and accurate risk stratification of cardiovascular disease (CVD) remain essential for reducing global mortality. While existing prediction models primarily leverage structured data, unstructured clinical notes contain…

Concept Bottleneck Models (CBMs) offer interpretable alternatives to black-box predictors by introducing human-relatable concepts before the final output. However, existing CBMs struggle to verify whether predicted concepts correspond to…