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Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Access to large-scale high-quality healthcare databases is key to accelerate medical research and make insightful discoveries about diseases. However, access to such data is often limited by patient privacy concerns, data sharing…

Automatic detection of depression is a rapidly growing field of research at the intersection of psychology and machine learning. However, with its exponential interest comes a growing concern for data privacy and scarcity due to the…

Machine Learning · Computer Science 2024-11-27 Andrea Kang , Jun Yu Chen , Zoe Lee-Youngzie , Shuhao Fu

The increasing use of synthetic data generated by Large Language Models (LLMs) presents both opportunities and challenges in data-driven applications. While synthetic data provides a cost-effective, scalable alternative to real-world data…

Computation and Language · Computer Science 2025-07-25 Tevin Atwal , Chan Nam Tieu , Yefeng Yuan , Zhan Shi , Yuhong Liu , Liang Cheng

Synthetic data offers a promising path to train models while preserving data privacy. Differentially private (DP) finetuning of large language models (LLMs) as data generator is effective, but is impractical when computation resources are…

Computation and Language · Computer Science 2025-07-18 Bowen Tan , Zheng Xu , Eric Xing , Zhiting Hu , Shanshan Wu

The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…

Synthetic Electronic Health Records (EHRs) offer a valuable opportunity to create privacy preserving and harmonized structured data, supporting numerous applications in healthcare. Key benefits of synthetic data include precise control over…

Computation and Language · Computer Science 2025-04-28 Yihan Lin , Zhirong Bella Yu , Simon Lee

Smartphone usage data can provide valuable insights for understanding interaction with technology and human behavior. However, collecting large-scale, in-the-wild smartphone usage logs is challenging due to high costs, privacy concerns,…

Human-Computer Interaction · Computer Science 2025-09-18 Gustavo Kruger , Nikhil Sachdeva , Michael Sobolev

LLMs have become increasingly capable at accomplishing a range of specialized-tasks and can be utilized to expand equitable access to medical knowledge. Most medical LLMs have involved extensive fine-tuning, leveraging specialized medical…

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Medical dialogue systems (MDS) enhance patient-physician communication, improve healthcare accessibility, and reduce costs. However, acquiring suitable data to train these systems poses significant challenges. Privacy concerns prevent the…

Computation and Language · Computer Science 2024-08-13 Trisha Das , Dina Albassam , Jimeng Sun

Large language models (LLMs) achieve strong performance across diverse tasks, largely driven by high-quality web data used in pre-training. However, recent studies indicate this data source is rapidly depleting. Synthetic data emerges as a…

Clinical Question Answering (QA) systems enable doctors to quickly access patient information from electronic health records (EHRs). However, training these systems requires significant annotated data, which is limited due to the expertise…

Computation and Language · Computer Science 2024-12-09 Fan Bai , Keith Harrigian , Joel Stremmel , Hamid Hassanzadeh , Ardavan Saeedi , Mark Dredze

Synthetic tabular data generation with differential privacy is a crucial problem to enable data sharing with formal privacy. Despite a rich history of methodological research and development, developing differentially private tabular data…

Machine Learning · Computer Science 2024-06-05 Toan V. Tran , Li Xiong

This survey reviews how large language models (LLMs) are transforming synthetic training data generation in both natural language and code domains. By producing artificial but task-relevant examples, these models can significantly augment…

Computation and Language · Computer Science 2025-11-21 Mihai Nadas , Laura Diosan , Andreea Tomescu

The rapid advancements in generative AI and large language models (LLMs) have opened up new avenues for producing synthetic data, particularly in the realm of structured tabular formats, such as product reviews. Despite the potential…

Machine Learning · Computer Science 2025-07-25 Yefeng Yuan , Yuhong Liu , Liang Cheng

Large language models (LLMs) can perform recommendation tasks by taking prompts written in natural language as input. Compared to traditional methods such as collaborative filtering, LLM-based recommendation offers advantages in handling…

Information Retrieval · Computer Science 2025-07-21 Genki Kusano , Kosuke Akimoto , Kunihiro Takeoka

Synthetic data has the potential to improve the performance, training efficiency, and privacy of real training examples. Nevertheless, existing approaches for synthetic text generation are mostly heuristics and cannot generate…

Machine Learning · Computer Science 2025-06-10 Dang Nguyen , Zeman Li , Mohammadhossein Bateni , Vahab Mirrokni , Meisam Razaviyayn , Baharan Mirzasoleiman

Privacy policies are often obfuscated by their complexity, which impedes transparency and informed consent. Conventional machine learning approaches for automatically analyzing these policies demand significant resources and substantial…

Computation and Language · Computer Science 2024-09-24 Arda Goknil , Femke B. Gelderblom , Simeon Tverdal , Shukun Tokas , Hui Song

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang
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