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Achieving an optimal biomechanical environment within bone scaffolds is critical for promoting tissue regeneration, particularly in load-bearing anatomical sites where rigid fixation can induce stress shielding and compromise healing.…

Developing clinically viable tissue-engineered cardiovascular implants remains a formidable challenge. Achieving reliable and durable outcomes requires a deeper understanding of the fundamental mechanisms driving tissue evolution during in…

Computational Engineering, Finance, and Science · Computer Science 2025-07-29 Mahmoud Sesa , Hagen Holthusen , Christian Böhm , Stefan Jockenhövel , Stefanie Reese , Kevin Linka

The aim of this work was to simulate the behaviour of hip prostheses under mechanical shocks. When hip joint is replaced by prosthesis, during the swing phase of the leg, a microseparation between the prosthetic head and the cup could…

Medical Physics · Physics 2012-03-29 Juliana Uribe , Jérôme Hausselle , Jean Geringer

A tunable stiffness bone rod was designed, optimized, and 3D printed to address the common shortcomings of existing bone rods in the healing of long fractured bones. The common deficiencies of existing bone fixations are high stiffness,…

Applied Physics · Physics 2025-07-25 Mohammad Saber Hashemi , Karl H. Kraus , Azadeh Sheidae

Several variants of the recently proposed Density Matrix Embedding Theory (DMET) [G. Knizia and G. K-L. Chan, Phys. Rev. Lett. 109, 186404 (2012)] are formulated and tested. We show that spin symmetry breaking of the lattice mean-field…

Strongly Correlated Electrons · Physics 2015-06-17 Ireneusz W. Bulik , Gustavo E. Scuseria , Jorge Dukelsky

This paper presents a density-based topology optimization approach to design structures under self-weight load. Such loads change their magnitude and/or location as the topology optimization advances and pose several unique challenges,…

Computational Engineering, Finance, and Science · Computer Science 2022-04-26 Prabhat Kumar

The objective of this study is to evaluate the mechanical properties and energy absorption characteristics of the gyroid, dual-lattice and spinodoid structures, as biomimetic lattices, through finite element analysis and experimental…

Medical Physics · Physics 2024-01-23 Mahtab Vafaeefar , Kevin M. Moerman , Ted J. Vaughan

In this paper, gradient-based optimization methods are combined with finite-element modeling for improving electric devices. Geometric design parameters are considered by affine decomposition of the geometry or by the design element…

To reduce the stress concentration and ensure the structural safety for lattice structure designs, in this paper, a new optimization framework is developed for the optimal design of graded lattice structures, innovatively integrating fillet…

Mesoscale and Nanoscale Physics · Physics 2021-03-08 Xiaoyang Wang , Lei Zhu , Liao Sun , Nan Li

Mitigating low-frequency noise is particularly challenging due to its limited natural attenuation. This study aims to design viscoelastic composite microstructures that achieve both low acoustic reflection and high internal damping by…

Applied Physics · Physics 2025-11-06 Hiroaki Deguchi , Kei Matsushima , Takayuki Yamada

An important step in shape optimization with partial differential equation constraints is to adapt the geometry during each optimization iteration. Common strategies are to employ mesh-deformation or re-meshing, where one or the other…

Numerical Analysis · Mathematics 2018-06-27 Jorgen S. Dokken , Simon W. Funke , August Johansson , Stephan Schmidt

Humans rely on multimodal perception to form representations of the world. This implies that environmental stimuli must remain consistent and predictable throughout their journey to our sensory organs. When it comes to vision,…

Materials Science · Physics 2024-08-14 Thomas Daunizeau , Sinan Haliyo , Vincent Hayward

We present a multi-phase design parameterization to obtain optimized heterogeneous lattice structures. The 3D domain is discretized into a cubical grid wherein each cube has eight distinct unit cell types or phases. When all phases are…

Materials Science · Physics 2021-03-04 Yash Agrawal , G. K. Ananthasuresh

In this paper, we develop a rigorous mathematical framework for the optimization of hip roof house geometry, with the primary goal of minimizing the external surface of the building envelope for a given set of design constraints. Five…

Optimization and Control · Mathematics 2026-01-21 Ewa Rokita-Magdziarz , Barbara Gronostajska , Marcin Magdziarz

This work introduces an Adaptive Mesh Refinement (AMR) strategy for the topology optimization of structures made of discrete geometric components using the geometry projection method. Practical structures made of geometric shapes such as…

Optimization and Control · Mathematics 2020-04-22 Shanglong Zhang , Arun L. Gain , Julian A. Norato

Since wearable linkage mechanisms could control the moment transmission from actuator(s) to wearers, they can help ensure that even low-cost wearable systems provide advanced functionality tailored to users' needs. For example, if a hip…

Robotics · Computer Science 2023-08-23 Seok Won Kang , Jegyeong Ryu , Suh In Kim , Youngsoo Kim , Yoon Young Kim

The development of tissue-engineered cardiovascular implants can improve the lives of large segments of our society who suffer from cardiovascular diseases. Regenerative tissues are fabricated using a process called tissue maturation.…

Computational Engineering, Finance, and Science · Computer Science 2025-03-24 Mahmoud Sesa , Hagen Holthusen , Lukas Lamm , Christian Böhm , Tim Brepols , Stefan Jockenhövel , Stefanie Reese

The development of porous polymeric membranes remains a labor-intensive process, often requiring extensive trial and error to identify optimal fabrication parameters. In this study, we present a fully automated platform for membrane…

This paper presents a homogenized topology optimization (TO) method for spatially optimizing cell-size distribution of triply-periodic minimal surface (TPMS) structures, with high accuracy in the optimized structural response after…

Optimization and Control · Mathematics 2026-05-08 Hiroki Kawabe , Kaito Ohtani , Yusibo Yang , Musaddiq Al Ali , Kentaro Yaji

This paper presents a genetic-based hybrid algorithm that combines the exploration power of Genetic Algorithm (GA) with the exploitation capacity of a phenotypical probabilistic local search algorithm. Though not limited to a certain class…

Optimization and Control · Mathematics 2016-11-26 Reza Najian Asl , Mohamad Aslani , Masoud Shariat Panahi