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By decomposing the image formation process into a sequential application of denoising autoencoders, diffusion models (DMs) achieve state-of-the-art synthesis results on image data and beyond. Additionally, their formulation allows for a…

Computer Vision and Pattern Recognition · Computer Science 2022-04-14 Robin Rombach , Andreas Blattmann , Dominik Lorenz , Patrick Esser , Björn Ommer

Image synthesis approaches, e.g., generative adversarial networks, have been popular as a form of data augmentation in medical image analysis tasks. It is primarily beneficial to overcome the shortage of publicly accessible data and…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Shiyi Du , Xiaosong Wang , Yongyi Lu , Yuyin Zhou , Shaoting Zhang , Alan Yuille , Kang Li , Zongwei Zhou

This study investigates the explainability of generative diffusion models in the context of medical imaging, focusing on Magnetic resonance imaging (MRI) synthesis. Although diffusion models have shown strong performance in generating…

Machine Learning · Computer Science 2026-04-23 Surjo Dey , Pallabi Saikia

Image-to-Image translation models can help mitigate various challenges inherent to medical image acquisition. Latent diffusion models (LDMs) leverage efficient learning in compressed latent space and constitute the core of state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Junhyeok Lee , Hyunwoong Kim , Hyungjin Chung , Heeseong Eom , Joon Jang , Chul-Ho Sohn , Kyu Sung Choi

A diffusion probabilistic model (DPM), which constructs a forward diffusion process by gradually adding noise to data points and learns the reverse denoising process to generate new samples, has been shown to handle complex data…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Zhengxiong Luo , Dayou Chen , Yingya Zhang , Yan Huang , Liang Wang , Yujun Shen , Deli Zhao , Jingren Zhou , Tieniu Tan

Conditional medical image generation plays an important role in many clinically relevant imaging tasks. However, existing methods still face a fundamental challenge in balancing inference efficiency, patient-specific fidelity, and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Zirong Li , Siyuan Mei , Weiwen Wu , Andreas Maier , Lina Gölz , Yan Xia

Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Yuli Wu , Weidong He , Dennis Eschweiler , Ningxin Dou , Zixin Fan , Shengli Mi , Peter Walter , Johannes Stegmaier

Synthetic cardiac MRI (CMRI) generation has emerged as a promising strategy to overcome the scarcity of annotated medical imaging data. Recent advances in GANs, VAEs, diffusion probabilistic models, and flow-matching techniques aim to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Ishan Kumarasinghe , Dasuni Kawya , Madhura Edirisooriya , Isuri Devindi , Isuru Nawinne , Vajira Thambawita

Diffusion-based generative models are extremely effective in generating high-quality images, with generated samples often surpassing the quality of those produced by other models under several metrics. One distinguishing feature of these…

Machine Learning · Computer Science 2022-10-25 Ashwini Pokle , Zhengyang Geng , Zico Kolter

Person image synthesis with controllable body poses and appearances is an essential task owing to the practical needs in the context of virtual try-on, image editing and video production. However, existing methods face significant…

Computer Vision and Pattern Recognition · Computer Science 2024-12-30 Enbo Huang , Yuan Zhang , Faliang Huang , Guangyu Zhang , Yang Liu

Data limitation is a significant challenge in applying deep learning to medical images. Recently, the diffusion probabilistic model (DPM) has shown the potential to generate high-quality images by converting Gaussian random noise into…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Sepehr Salem Ghahfarokhi , Tyrell To , Julie Jorns , Tina Yen , Bing Yu , Dong Hye Ye

Deep learning models in medical contexts face challenges like data scarcity, inhomogeneity, and privacy concerns. This study focuses on improving ventricular segmentation in brain MRI images using synthetic data. We employed two latent…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Tim Ruschke , Jonathan Frederik Carlsen , Adam Espe Hansen , Ulrich Lindberg , Amalie Monberg Hindsholm , Martin Norgaard , Claes Nøhr Ladefoged

Latent diffusion models (LDMs) dominate high-quality image generation, yet integrating representation learning with generative modeling remains a challenge. We introduce a novel generative image modeling framework that seamlessly bridges…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Theodoros Kouzelis , Efstathios Karypidis , Ioannis Kakogeorgiou , Spyros Gidaris , Nikos Komodakis

Generative models based on deep learning have shown significant potential in medical imaging, particularly for modality transformation and multimodal fusion in MRI-based brain imaging. This study introduces GM-LDM, a novel framework that…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Hu Xu , Yang Jingling , Jia Sihan , Bi Yuda , Calhoun Vince

Image synthesis has seen significant advancements with the advent of diffusion-based generative models like Denoising Diffusion Probabilistic Models (DDPM) and text-to-image diffusion models. Despite their efficacy, there is a dearth of…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Ruipeng Ma , Jinhao Duan , Fei Kong , Xiaoshuang Shi , Kaidi Xu

Diffusion magnetic resonance imaging (diffusion MRI) is a non-invasive microstructure assessment technique. Scalar measures, such as FA (fractional anisotropy) and MD (mean diffusivity), quantifying micro-structural tissue properties can be…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Xuan Gu , Hans Knutsson , Markus Nilsson , Anders Eklund

Over the past decade, there has been tremendous progress in creating synthetic media, mainly thanks to the development of powerful methods based on generative adversarial networks (GAN). Very recently, methods based on diffusion models (DM)…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Riccardo Corvi , Davide Cozzolino , Giada Zingarini , Giovanni Poggi , Koki Nagano , Luisa Verdoliva

The introduction of diffusion models in anomaly detection has paved the way for more effective and accurate image reconstruction in pathologies. However, the current limitations in controlling noise granularity hinder diffusion models'…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Cosmin I. Bercea , Michael Neumayr , Daniel Rueckert , Julia A. Schnabel

Diffusion models have become a leading approach for high-fidelity medical image synthesis. However, most existing methods for 3D medical image generation rely on convolutional U-Net backbones within latent diffusion frameworks. While…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Marvin Seyfarth , Salman Ul Hassan Dar , Yannik Frisch , Philipp Wild , Norbert Frey , Florian André , Sandy Engelhardt

Denosing diffusion model, as a generative model, has received a lot of attention in the field of image generation recently, thanks to its powerful generation capability. However, diffusion models have not yet received sufficient research in…

Computer Vision and Pattern Recognition · Computer Science 2023-04-12 ZiHan Cao , ShiQi Cao , Xiao Wu , JunMing Hou , Ran Ran , Liang-Jian Deng