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Causal machine learning (ML) offers flexible, data-driven methods for predicting treatment outcomes including efficacy and toxicity, thereby supporting the assessment and safety of drugs. A key benefit of causal ML is that it allows for…

Modern machine learning (ML) methods typically fail to adequately capture causal information. Consequently, such models do not handle data distributional shifts, are vulnerable to adversarial examples, and often learn spurious correlations.…

Quantum Physics · Physics 2026-01-27 Rishi Goel , Casey R. Myers , Sally Shrapnel

Automatic diagnosis is a significant application of AI in healthcare, where diagnoses are generated based on the symptom description of patients. Previous works have approached this task directly by modeling the relationship between the…

Computation and Language · Computer Science 2024-01-30 Haochun Wang , Sendong Zhao , Zewen Qiang , Nuwa Xi , Bing Qin , Ting Liu

Despite Large Language Models' remarkable capabilities, understanding their internal representations remains challenging. Mechanistic interpretability tools such as sparse autoencoders (SAEs) were developed to extract interpretable features…

Machine Learning · Computer Science 2026-01-06 Xiangchen Song , Jiaqi Sun , Zijian Li , Yujia Zheng , Kun Zhang

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

There are two main barriers to using large language models (LLMs) in clinical reasoning. Firstly, while LLMs exhibit significant promise in Natural Language Processing (NLP) tasks, their performance in complex reasoning and planning falls…

Artificial Intelligence · Computer Science 2024-12-31 Shengxin Hong , Liang Xiao , Xin Zhang , Jianxia Chen

Modern engineering increasingly relies on vast datasets generated by experiments and simulations, driving a growing demand for efficient, reliable, and broadly applicable modeling strategies. There is also heightened interest in developing…

Artificial Intelligence · Computer Science 2025-10-03 Yang Liu , Zaid Abulawi , Abhiram Garimidi , Doyeong Lim

Large language models (LLMs) have revolutionized natural language processing (NLP), particularly through Retrieval-Augmented Generation (RAG), which enhances LLM capabilities by integrating external knowledge. However, traditional RAG…

Computation and Language · Computer Science 2025-10-23 Nengbo Wang , Xiaotian Han , Jagdip Singh , Jing Ma , Vipin Chaudhary

In the presence of confounding between an endogenous variable and the outcome, instrumental variables (IVs) are used to isolate the causal effect of the endogenous variable. Identifying valid instruments requires interdisciplinary…

Artificial Intelligence · Computer Science 2026-04-07 Ivaxi Sheth , Zhijing Jin , Bryan Wilder , Dominik Janzing , Mario Fritz

Causal world models are systems that can answer counterfactual questions about an environment of interest, i.e. predict how it would have evolved if an arbitrary subset of events had been realized differently. It requires understanding the…

Artificial Intelligence · Computer Science 2025-05-21 Gaël Gendron , Jože M. Rožanec , Michael Witbrock , Gillian Dobbie

We propose a novel framework that leverages LLMs for full causal graph discovery. While previous LLM-based methods have used a pairwise query approach, this requires a quadratic number of queries which quickly becomes impractical for larger…

Machine Learning · Computer Science 2026-04-06 Thomas Jiralerspong , Xiaoyin Chen , Yash More , Vedant Shah , Yoshua Bengio

The ability to perform causal reasoning is widely considered a core feature of intelligence. In this work, we investigate whether large language models (LLMs) can coherently reason about causality. Much of the existing work in natural…

We propose a hybrid architecture that integrates decision tree-based symbolic reasoning with the generative capabilities of large language models (LLMs) within a coordinated multi-agent framework. Unlike prior approaches that loosely couple…

Artificial Intelligence · Computer Science 2025-08-08 Andrew Kiruluta

As language models (LMs) deliver increasing performance on a range of NLP tasks, probing classifiers have become an indispensable technique in the effort to better understand their inner workings. A typical setup involves (1) defining an…

Computation and Language · Computer Science 2024-08-01 Charles Jin , Martin Rinard

Traditional causal discovery methods often depend on strong, untestable assumptions, making them unreliable in real-world applications. In this context, Large Language Models (LLMs) have emerged as a promising alternative for extracting…

Artificial Intelligence · Computer Science 2026-03-31 Federico Baldo , Simon Ferreira , Charles K. Assaad

Multi-agent systems built on Large Language Models (LLMs) show exceptional promise for complex collaborative problem-solving, yet they face fundamental challenges stemming from context window limitations that impair memory consistency, role…

Artificial Intelligence · Computer Science 2026-01-13 Sizhe Yuen , Francisco Gomez Medina , Ting Su , Yali Du , Adam J. Sobey

In practical statistical causal discovery (SCD), embedding domain expert knowledge as constraints into the algorithm is important for reasonable causal models reflecting the broad knowledge of domain experts, despite the challenges in the…

Machine Learning · Computer Science 2025-05-13 Masayuki Takayama , Tadahisa Okuda , Thong Pham , Tatsuyoshi Ikenoue , Shingo Fukuma , Shohei Shimizu , Akiyoshi Sannai

Tool learning empowers large language models (LLMs) as agents to use external tools and extend their utility. Existing methods employ one single LLM-based agent to iteratively select and execute tools, thereafter incorporating execution…

Computation and Language · Computer Science 2024-06-25 Zhengliang Shi , Shen Gao , Xiuyi Chen , Yue Feng , Lingyong Yan , Haibo Shi , Dawei Yin , Pengjie Ren , Suzan Verberne , Zhaochun Ren

Urban causal research is essential for understanding the complex, dynamic processes that shape cities and for informing evidence-based policies. However, current practices are often constrained by inefficient and biased hypothesis…

Computation and Language · Computer Science 2025-06-23 Yutong Xia , Ao Qu , Yunhan Zheng , Yihong Tang , Dingyi Zhuang , Yuxuan Liang , Shenhao Wang , Cathy Wu , Lijun Sun , Roger Zimmermann , Jinhua Zhao

Large Language Models (LLMs) have demonstrated strong performance across a wide range of tasks, yet they still struggle with complex mathematical reasoning, a challenge fundamentally rooted in deep structural dependencies. To address this…

Artificial Intelligence · Computer Science 2025-12-01 Lei Zan , Keli Zhang , Ruichu Cai , Lujia Pan