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Accurately measuring protein-RNA binding affinity is crucial in many biological processes and drug design. Previous computational methods for protein-RNA binding affinity prediction rely on either sequence or structure features, unable to…

Biomolecules · Quantitative Biology 2025-01-06 Rong Han , Xiaohong Liu , Tong Pan , Jing Xu , Xiaoyu Wang , Wuyang Lan , Zhenyu Li , Zixuan Wang , Jiangning Song , Guangyu Wang , Ting Chen

We introduce LLaDA-MoE, a large language diffusion model with the Mixture-of-Experts (MoE) architecture, trained from scratch on approximately 20T tokens. LLaDA-MoE achieves competitive performance with significantly reduced computational…

The integration of multi-modal Magnetic Resonance Imaging (MRI) and clinical data holds great promise for enhancing the diagnosis of neurological disorders (NDs) in real-world clinical settings. Deep Learning (DL) has recently emerged as a…

Image and Video Processing · Electrical Eng. & Systems 2025-06-19 Wajih Hassan Raza , Aamir Bader Shah , Yu Wen , Yidan Shen , Juan Diego Martinez Lemus , Mya Caryn Schiess , Timothy Michael Ellmore , Renjie Hu , Xin Fu

Large Language Models (LLMs) have demonstrated remarkable abilities in tackling a wide range of complex tasks. However, their huge computational and memory costs raise significant challenges in deploying these models on resource-constrained…

Pretraining on a large-scale corpus has become a standard method to build general language models (LMs). Adapting a model to new data distributions targeting different downstream tasks poses significant challenges. Naive fine-tuning may…

Computation and Language · Computer Science 2023-05-23 Wuyang Chen , Yanqi Zhou , Nan Du , Yanping Huang , James Laudon , Zhifeng Chen , Claire Cu

Large language models (LLMs) with the Mixture-of-Experts (MoE) architecture achieve high cost-efficiency by selectively activating a subset of the parameters. Despite the inference efficiency of MoE LLMs, the training of extensive experts…

Computation and Language · Computer Science 2025-06-12 Yuchen Feng , Bowen Shen , Naibin Gu , Jiaxuan Zhao , Peng Fu , Zheng Lin , Weiping Wang

Large Language Models (LLMs) have shown great promise in multilingual machine translation (MT), even with limited bilingual supervision. However, fine-tuning LLMs with parallel corpora presents major challenges, namely parameter…

Computation and Language · Computer Science 2026-05-26 Bo Li , Tianyu Dong , Shaolin Zhu , Deyi Xiong

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Large Vision-Language Models (LVLMs) have demonstrated impressive performance on multimodal tasks through scaled architectures and extensive training. However, existing Mixture of Experts (MoE) approaches face challenges due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Heng Zhang , Haichuan Hu , Yaomin Shen , Weihao Yu , Yilei Yuan , Haochen You , Guo Cheng , Zijian Zhang , Lubin Gan , Huihui Wei , Hao Zhang , Jin Huang

Mixture-of-Experts (MoE) models are designed to enhance the efficiency of large language models (LLMs) without proportionally increasing the computational demands. However, their deployment on edge devices still faces significant challenges…

Machine Learning · Computer Science 2024-08-21 Shuzhang Zhong , Ling Liang , Yuan Wang , Runsheng Wang , Ru Huang , Meng Li

Large language models (LLMs) have garnered unprecedented advancements across diverse fields, ranging from natural language processing to computer vision and beyond. The prowess of LLMs is underpinned by their substantial model size,…

Machine Learning · Computer Science 2025-04-10 Weilin Cai , Juyong Jiang , Fan Wang , Jing Tang , Sunghun Kim , Jiayi Huang

Mixture of Experts (MoE) architectures have recently advanced the scalability and adaptability of large language models (LLMs) for continual multimodal learning. However, efficiently extending these models to accommodate sequential tasks…

Computation and Language · Computer Science 2025-06-26 Hengyuan Zhao , Ziqin Wang , Qixin Sun , Kaiyou Song , Yilin Li , Xiaolin Hu , Qingpei Guo , Si Liu

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

The Mixture of Experts (MoE) architecture has emerged as a powerful paradigm for scaling large language models (LLMs) while maintaining inference efficiency. However, their enormous memory requirements make them prohibitively expensive to…

Machine Learning · Computer Science 2025-06-24 Zichong Li , Chen Liang , Zixuan Zhang , Ilgee Hong , Young Jin Kim , Weizhu Chen , Tuo Zhao

In order to streamline the fine-tuning of foundation models, Low-Rank Adapters (LoRAs) have been substantially adopted across various fields, including instruction tuning and domain adaptation. The underlying concept of LoRA involves…

Machine Learning · Computer Science 2025-02-25 Mengyang Sun , Yihao Wang , Tao Feng , Dan Zhang , Yifan Zhu , Jie Tang

The advent of Large Language Models (LLMs) has ushered in a new era of artificial intelligence, with the potential to transform various sectors through automation and insightful analysis. The Mixture of Experts (MoE) architecture has been…

Machine Learning · Computer Science 2024-10-22 Xurui Li , Juanjuan Yao

Mixture-of-Experts (MoE) language models can reduce computational costs by 2-4$\times$ compared to dense models without sacrificing performance, making them more efficient in computation-bounded scenarios. However, MoE models generally…

Machine Learning · Computer Science 2024-04-09 Bowen Pan , Yikang Shen , Haokun Liu , Mayank Mishra , Gaoyuan Zhang , Aude Oliva , Colin Raffel , Rameswar Panda

Mixture-of-Expert (MoE) models have obtained state-of-the-art performance in Neural Machine Translation (NMT) tasks. Existing works in MoE mostly consider a homogeneous design where the same number of experts of the same size are placed…

The recent success of specialized Large Language Models (LLMs) in domains such as mathematical reasoning and coding has led to growing interest in methods for merging these expert LLMs into a unified Mixture-of-Experts (MoE) model, with the…

Computation and Language · Computer Science 2025-02-18 Yuhang Zhou , Giannis Karamanolakis , Victor Soto , Anna Rumshisky , Mayank Kulkarni , Furong Huang , Wei Ai , Jianhua Lu

Training large language models (LLMs) for different inference constraints is computationally expensive, limiting control over efficiency-accuracy trade-offs. Moreover, once trained, these models typically process tokens uniformly,…

Computation and Language · Computer Science 2025-02-19 Kumari Nishu , Sachin Mehta , Samira Abnar , Mehrdad Farajtabar , Maxwell Horton , Mahyar Najibi , Moin Nabi , Minsik Cho , Devang Naik