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Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…
INTRODUCTION: Heterogeneity in the progression of Alzheimer's disease makes it challenging to predict the rate of cognitive and functional decline for individual patients. Tools for short-term prediction could help enrich clinical trial…
The early signs of cognitive decline are often noticeable in conversational speech, and identifying those signs is crucial in dealing with later and more serious stages of neurodegenerative diseases. Clinical detection is costly and…
Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…
Cognitive impairments in older adults represent a significant public health concern, necessitating accurate diagnostic and monitoring strategies. In this study, the principal cognitive and neuropsychological evaluations employed for the…
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that leads to dementia, and early intervention can greatly benefit from analyzing linguistic abnormalities. In this work, we explore the potential of Large Language Models…
We present two multimodal fusion-based deep learning models that consume ASR transcribed speech and acoustic data simultaneously to classify whether a speaker in a structured diagnostic task has Alzheimer's Disease and to what degree,…
Quantum machine learning is a new research field combining quantum information science and machine learning. Quantum computing technologies appear to be particularly well-suited for addressing problems in the health sector efficiently. They…
Diagnosing Autism Spectrum Disorder (ASD) is a challenging problem, and is based purely on behavioral descriptions of symptomology (DSM-5/ICD-10), and requires informants to observe children with disorder across different settings (e.g.…
Speech-comprehension difficulties are common among older people. Standard speech tests do not fully capture such difficulties because the tests poorly resemble the context-rich, story-like nature of ongoing conversation and are typically…
Early detection of dementia is crucial to devise effective interventions. Comprehensive cognitive tests, while being the most accurate means of diagnosis, are long and tedious, thus limiting their applicability to a large population,…
Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. This model is based in first principles. A…
The ageing population trend is correlated with an increased prevalence of acquired cognitive impairments such as dementia. Although there is no cure for dementia, a timely diagnosis helps in obtaining necessary support and appropriate…
Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…
Deficits in working memory, which includes both the ability to learn and to retain information short-term, are a hallmark of many cognitive disorders. Our study analyzes data from a neuroscience experiment on animal subjects, where…
Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…
Embedded in any speech signal is a rich combination of cognitive, neuromuscular and physiological information. This richness makes speech a powerful signal in relation to a range of different health conditions, including major depressive…
Healthcare datasets present many challenges to both machine learning and statistics as their data are typically heterogeneous, censored, high-dimensional and have missing information. Feature selection is often used to identify the…
Brain positron emission tomography (PET) imaging is broadly used in research and clinical routines to study, diagnose, and stage Alzheimer's disease (AD). However, its potential cannot be fully exploited yet due to the lack of portable…
Speech impairments resulting from congenital disorders, such as cerebral palsy, down syndrome, or apert syndrome, as well as acquired brain injuries due to stroke, traumatic accidents, or tumors, present major challenges to automatic speech…