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Clinical diagnosis begins with doctor-patient interaction, during which physicians iteratively gather information, determine examination and refine differential diagnosis through patients' response. This dynamic clinical-reasoning process…

Computation and Language · Computer Science 2025-12-30 Yuqi Tang , Jing Yu , Zichang Su , Kehua Feng , Zhihui Zhu , Libin Wang , Lei Liang , Qiang Zhang , Keyan Ding , Huajun Chen

Patient simulators are gaining traction in mental health training by providing scalable exposure to complex and sensitive patient interactions. Simulating depressed patients is particularly challenging, as safety constraints and high…

Computation and Language · Computer Science 2026-04-29 Nguyen Khoi Hoang , Shuhaib Mehri , Tse-An Hsu , Yi-Jyun Sun , Quynh Xuan Nguyen Truong , Khoa D Doan , Dilek Hakkani-Tür

Training mental health clinicians to conduct standardized clinical assessments is challenging due to a lack of scalable, realistic practice opportunities, which can impact data quality in clinical trials. To address this gap, we introduce a…

Human-Computer Interaction · Computer Science 2025-12-30 Veronica Bossio Botero , Vijay Yadav , Jacob Ouyang , Anzar Abbas , Michelle Worthington

LLM-based client simulation has emerged as a promising tool for training novice counselors and evaluating automated counseling systems. However, existing client simulation approaches face three key challenges: (1) limited diversity and…

Computation and Language · Computer Science 2026-01-13 Huachuan Qiu , Zhaoming Chen , Yuqian Chen , Yuan Xie , Yu Lu , Zhenzhong Lan

Patient simulation is essential for developing and evaluating mental health dialogue systems. As most existing approaches rely on snapshot-style prompts with limited profile information, homogeneous behaviors and incoherent disease…

Computation and Language · Computer Science 2026-03-25 Baihan Li , Bingrui Jin , Kunyao Lan , Ming Wang , Mengyue Wu

Depression-diagnosis-oriented chat aims to guide patients in self-expression to collect key symptoms for depression detection. Recent work focuses on combining task-oriented dialogue and chitchat to simulate the interview-based depression…

Human-Computer Interaction · Computer Science 2025-08-21 Yiyang Gu , Yougen Zhou , Qin Chen , Ningning Zhou , Jie Zhou , Aimin Zhou , Liang He

Mental health issues, particularly depressive disorders, present significant challenges in contemporary society, necessitating the development of effective automated diagnostic methods. This paper introduces the Agent Mental Clinic (AMC), a…

Computation and Language · Computer Science 2024-10-10 Kunyao Lan , Bingrui Jin , Zichen Zhu , Siyuan Chen , Shu Zhang , Kenny Q. Zhu , Mengyue Wu

Conversational diagnosis requires multi-turn history-taking, where an agent asks clarifying questions to refine differential diagnoses under incomplete information. Existing approaches often rely on the parametric knowledge of a model or…

Artificial Intelligence · Computer Science 2026-02-04 Jeongmoon Won , Seungwon Kook , Yohan Jo

Dialogue systems for mental health care aim to provide appropriate support to individuals experiencing mental distress. While extensive research has been conducted to deliver adequate emotional support, existing studies cannot identify…

Computation and Language · Computer Science 2024-08-13 Seungyeon Seo , Gary Geunbae Lee

The shortage of clinical workforce presents significant challenges in mental healthcare, limiting access to formal diagnostics and services. We aim to tackle this shortage by integrating a customized large language model (LLM) into the…

Computation and Language · Computer Science 2025-05-02 Sichang Tu , Abigail Powers , Natalie Merrill , Negar Fani , Sierra Carter , Stephen Doogan , Jinho D. Choi

The severe shortage of medical doctors limits access to timely and reliable healthcare, leaving millions underserved. Large language models (LLMs) offer a potential solution but struggle in real-world clinical interactions. Many LLMs are…

Computation and Language · Computer Science 2026-05-11 Jiayuan Zhu , Jiazhen Pan , Yuyuan Liu , Fenglin Liu , Junde Wu

Doctor-patient consultations require multi-turn, context-aware communication tailored to diverse patient personas. Training or evaluating doctor LLMs in such settings requires realistic patient interaction systems. However, existing…

Artificial Intelligence · Computer Science 2025-10-30 Daeun Kyung , Hyunseung Chung , Seongsu Bae , Jiho Kim , Jae Ho Sohn , Taerim Kim , Soo Kyung Kim , Edward Choi

Objectives: While Large Language Models (LLMs) have been widely used to assist clinicians and support patients, no existing work has explored dialogue systems for standard diagnostic interviews and assessments. This study aims to bridge the…

Computation and Language · Computer Science 2025-05-01 Sichang Tu , Abigail Powers , Stephen Doogan , Jinho D. Choi

Automatic detection of depression is a rapidly growing field of research at the intersection of psychology and machine learning. However, with its exponential interest comes a growing concern for data privacy and scarcity due to the…

Machine Learning · Computer Science 2024-11-27 Andrea Kang , Jun Yu Chen , Zoe Lee-Youngzie , Shuhao Fu

Large language models (LLMs) hold significant potential for mental health support, capable of generating empathetic responses and simulating therapeutic conversations. However, existing LLM-based approaches often lack the clinical grounding…

Computation and Language · Computer Science 2025-11-04 He Hu , Yucheng Zhou , Juzheng Si , Qianning Wang , Hengheng Zhang , Fuji Ren , Fei Ma , Laizhong Cui , Qi Tian

The development of AI for mental health is hindered by a lack of authentic therapy dialogues, due to strict privacy regulations and the fact that clinical sessions were historically rarely recorded. We present an LLM-driven pipeline that…

Depression is a widespread mental disorder that affects millions worldwide. While automated depression assessment shows promise, most studies rely on limited or non-clinically validated data, and often prioritize complex model design over…

Computation and Language · Computer Science 2025-08-07 Zhuang Chen , Guanqun Bi , Wen Zhang , Jiawei Hu , Aoyun Wang , Xiyao Xiao , Kun Feng , Minlie Huang

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes

Passively collected behavioral health data from ubiquitous sensors holds significant promise to provide mental health professionals insights from patient's daily lives; however, developing analysis tools to use this data in clinical…

Depression remains widely underdiagnosed and undertreated because stigma and subjective symptom ratings hinder reliable screening. To address this challenge, we propose a coarse-to-fine, multi-stage framework that leverages large language…

Artificial Intelligence · Computer Science 2026-04-14 Shiyu Teng , Jiaqing Liu , Hao Sun , Yu Li , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-Wei Chen
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