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Ancestral recombination graphs (ARGs) encode the complete genealogical history of a population of recombining lineages. ARGs, and their succinct representation, tree sequences, are increasingly central to modern population genetics methods,…

Populations and Evolution · Quantitative Biology 2025-10-09 Christopher Talbot , Gideon Bradburd

In the presence of recombination, the evolutionary relationships between a set of sampled genomes cannot be described by a single genealogical tree. Instead, the genomes are related by a complex, interwoven collection of genealogies…

Populations and Evolution · Quantitative Biology 2023-10-19 Alexander L. Lewanski , Michael C. Grundler , Gideon S. Bradburd

There is little debate about the importance of the ancestral recombination graph in population genetics. An important theoretical tool, the main obstacle to its widespread usage is the computational cost required to match the…

Populations and Evolution · Quantitative Biology 2026-05-14 Patrick Fournier , Fabrice Larribe

The complex correlation structure of a collection of orthologous DNA sequences is uniquely captured by the "ancestral recombination graph" (ARG), a complete record of coalescence and recombination events in the history of the sample.…

Populations and Evolution · Quantitative Biology 2013-12-04 Matthew D. Rasmussen , Melissa J. Hubisz , Ilan Gronau , Adam Siepel

The ancestral recombination graph (ARG) is the model of choice in statistical genetics to model population ancestries. Software capable of simulating ARGs on a genome scale within a reasonable amount of time are now widely available for…

Genomics · Quantitative Biology 2026-04-15 Patrick Fournier , Fabrice Larribe

The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene…

Quantitative Methods · Quantitative Biology 2016-09-28 Pablo G. Camara , Arnold J. Levine , Raul Rabadan

Recombination is a powerful evolutionary process that shapes the genetic diversity observed in the populations of many species. Reconstructing genealogies in the presence of recombination from sequencing data is a very challenging problem,…

Populations and Evolution · Quantitative Biology 2022-06-01 Elizabeth Hayman , Anastasia Ignatieva , Jotun Hein

Graph-based Retrieval-Augmented Generation (RAG) has shown great capability in enhancing Large Language Model (LLM)'s answer with an external knowledge base. Compared to traditional RAG, it introduces a graph as an intermediate…

Information Retrieval · Computer Science 2025-06-18 Ke Wang , Bo Pan , Yingchaojie Feng , Yuwei Wu , Jieyi Chen , Minfeng Zhu , Wei Chen

Graphs are widely adopted tools for encoding information. Generally, they are applied to disparate research fields where data needs to be represented in terms of local and spatial connections. In this context, a structure for ditigal image…

Image and Video Processing · Electrical Eng. & Systems 2019-12-23 Mario Manzo

The reconstruction of possible histories given a sample of genetic data in the presence of recombination and recurrent mutation is a challenging problem, but can provide key insights into the evolution of a population. We present KwARG,…

Populations and Evolution · Quantitative Biology 2021-05-14 Anastasia Ignatieva , Rune B. Lyngsø , Paul A. Jenkins , Jotun Hein

Retrieval-augmented generation (RAG) is a powerful technique that enhances downstream task execution by retrieving additional information, such as knowledge, skills, and tools from external sources. Graph, by its intrinsic "nodes connected…

Graph data have become increasingly common. Visualizing them helps people better understand relations among entities. Unfortunately, existing graph visualization tools are primarily designed for single-person desktop use, offering limited…

Human-Computer Interaction · Computer Science 2020-08-28 Siwei Li , Zhiyan Zhou , Anish Upadhayay , Omar Shaikh , Scott Freitas , Haekyu Park , Zijie J. Wang , Susanta Routray , Matthew Hull , Duen Horng Chau

We developed DyGETViz, a novel framework for effectively visualizing dynamic graphs (DGs) that are ubiquitous across diverse real-world systems. This framework leverages recent advancements in discrete-time dynamic graph (DTDG) models to…

Machine Learning · Computer Science 2024-07-01 Yiqiao Jin , Andrew Zhao , Yeon-Chang Lee , Meng Ye , Ajay Divakaran , Srijan Kumar

Data visualisation is a key tool in data mining for understanding big datasets. Many visualisation methods have been proposed, including the well-regarded state-of-the-art method t-Distributed Stochastic Neighbour Embedding. However, the…

Neural and Evolutionary Computing · Computer Science 2020-01-29 Andrew Lensen , Bing Xue , Mengjie Zhang

We introduce Artifact-Based Rendering (ABR), a framework of tools, algorithms, and processes that makes it possible to produce real, data-driven 3D scientific visualizations with a visual language derived entirely from colors, lines,…

Temporal interaction graphs (TIGs), defined by sequences of timestamped interaction events, have become ubiquitous in real-world applications due to their capability to model complex dynamic system behaviors. As a result, temporal…

Machine Learning · Computer Science 2025-12-19 Pengfei Jiao , Hongjiang Chen , Xuan Guo , Zhidong Zhao , Dongxiao He , Di Jin

The effective visualization of genomic data is crucial for exploring and interpreting complex relationships within and across genes and genomes. Despite advances in developing dedicated bioinformatics software, common visualization tools…

Genomics · Quantitative Biology 2024-11-22 Thomas Hackl , Markus Ankenbrand , Bart van Adrichem , David Wilkins , Kristina Haslinger

Recently, Retrieval-Augmented Generation (RAG) has achieved remarkable success in addressing the challenges of Large Language Models (LLMs) without necessitating retraining. By referencing an external knowledge base, RAG refines LLM…

Artificial Intelligence · Computer Science 2024-09-11 Boci Peng , Yun Zhu , Yongchao Liu , Xiaohe Bo , Haizhou Shi , Chuntao Hong , Yan Zhang , Siliang Tang

In causal graphical models based on directed acyclic graphs (DAGs), directed paths represent causal pathways between the corresponding variables. The variable at the beginning of such a path is referred to as an ancestor of the variable at…

Machine Learning · Computer Science 2021-05-24 Wenyu Chen , Mathias Drton , Ali Shojaie
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