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Model-free reinforcement learning (RL) is inherently a reactive method, operating under the assumption that it starts with no prior knowledge of the system and entirely depends on trial-and-error for learning. This approach faces several…

We present a reinforcement learning (RL) framework to synthesize a control policy from a given linear temporal logic (LTL) specification in an unknown stochastic environment that can be modeled as a Markov Decision Process (MDP).…

Robotics · Computer Science 2026-04-07 Alper Kamil Bozkurt , Yu Wang , Michael M. Zavlanos , Miroslav Pajic

This paper presents a real time, data driven decision support framework for epidemic control. We combine a compartmental epidemic model with sequential Bayesian inference and reinforcement learning (RL) controllers that adaptively choose…

Methodology · Statistics 2025-11-25 Giacomo Iannucci , Petros Barmpounakis , Alexandros Beskos , Nikolaos Demiris

Mediation analysis learns the causal effect transmitted via mediator variables between treatments and outcomes and receives increasing attention in various scientific domains to elucidate causal relations. Most existing works focus on…

Machine Learning · Statistics 2023-09-06 Lin Ge , Jitao Wang , Chengchun Shi , Zhenke Wu , Rui Song

While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge.…

Systems and Control · Electrical Eng. & Systems 2022-06-30 Bhabani Shankar Dey , Anirudh Nath , Abhilash Patel , Indra Narayan Kar

There is increasing interest in data-driven approaches for recommending optimal treatment strategies in many chronic disease management and critical care applications. Reinforcement learning methods are well-suited to this sequential…

Machine Learning · Computer Science 2023-06-14 Milashini Nambiar , Supriyo Ghosh , Priscilla Ong , Yu En Chan , Yong Mong Bee , Pavitra Krishnaswamy

Objective: The artificial pancreas (AP) has shown promising potential in achieving closed-loop glucose control for individuals with type 1 diabetes mellitus (T1DM). However, designing an effective control policy for the AP remains…

Artificial Intelligence · Computer Science 2023-07-17 Wenzhou Lv , Tianyu Wu , Luolin Xiong , Liang Wu , Jian Zhou , Yang Tang , Feng Qian

Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…

Quantitative Methods · Quantitative Biology 2025-02-04 Soon Jynn Chu , Nalaka Amarasiri , Sandesh Giri , Priyata Kafle

Several studies have employed reinforcement learning (RL) to address the challenges of regional adaptive traffic signal control (ATSC) and achieved promising results. In this field, existing research predominantly adopts multi-agent…

Artificial Intelligence · Computer Science 2026-01-14 Qiang Li , Ningjing Zeng , Lina Yu

Reinforcement learning (RL) is a promising approach. However, success is limited to real-world applications, because ensuring safe exploration and facilitating adequate exploitation is a challenge for controlling robotic systems with…

Robotics · Computer Science 2022-08-29 Mingyu Cai , Cristian-Ioan Vasile

Reinforcement learning (RL) is a sub-domain of machine learning, mainly concerned with solving sequential decision-making problems by a learning agent that interacts with the decision environment to improve its behavior through the reward…

Machine Learning · Computer Science 2025-09-23 Hossein Hassani , Ehsan Hallaji , Roozbeh Razavi-Far , Mehrdad Saif , Liang Lin

Robust reinforcement learning (RL) is to find a policy that optimizes the worst-case performance over an uncertainty set of MDPs. In this paper, we focus on model-free robust RL, where the uncertainty set is defined to be centering at a…

Machine Learning · Computer Science 2021-10-29 Yue Wang , Shaofeng Zou

State of the art methods for target tracking with sensor management (or controlled sensing) are model-based and are obtained through solutions to Partially Observable Markov Decision Process (POMDP) formulations. In this paper a…

Signal Processing · Electrical Eng. & Systems 2024-07-22 Adarsh M. Subramaniam , Argyrios Gerogiannis , James Z. Hare , Venugopal V. Veeravalli

Meta reinforcement learning (RL) allows agents to leverage experience across a distribution of tasks on which the agent can train at will, enabling faster learning of optimal policies on new test tasks. Despite its success in improving…

Machine Learning · Computer Science 2026-05-27 Tingting Ni , Maryam Kamgarpour

By formulating data samples' formation as a Markov denoising process, diffusion models achieve state-of-the-art performances in a collection of tasks. Recently, many variants of diffusion models have been proposed to enable controlled…

Machine Learning · Computer Science 2023-04-17 Hengtong Zhang , Tingyang Xu

Reinforcement Learning (RL) can be used to fit a mapping from patient state to a medication regimen. Prior studies have used deterministic and value-based tabular learning to learn a propofol dose from an observed anesthetic state. Deep RL…

Machine Learning · Computer Science 2020-09-10 Gabe Schamberg , Marcus Badgeley , Emery N. Brown

Care coordination and population health management programs serve large Medicaid and safety-net populations and must be auditable, efficient, and adaptable. While clinical risk for outreach modalities is typically low, time and opportunity…

Computers and Society · Computer Science 2025-09-23 Sanjay Basu , Sadiq Y. Patel , Parth Sheth , Bhairavi Muralidharan , Namrata Elamaran , Aakriti Kinra , Rajaie Batniji

This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state…

Artificial Intelligence · Computer Science 2018-01-30 Ning Liu , Ying Liu , Brent Logan , Zhiyuan Xu , Jian Tang , Yanzhi Wang

This paper investigates the problem of designing control policies that satisfy high-level specifications described by signal temporal logic (STL) in unknown, stochastic environments. While many existing works concentrate on optimizing the…

Systems and Control · Electrical Eng. & Systems 2024-12-16 Siqi Wang , Shaoyuan Li , Li Yin , Xiang Yin

The development of closed-loop systems for glycemia control in type I diabetes relies heavily on simulated patients. Improving the performances and adaptability of these close-loops raises the risk of over-fitting the simulator. This may…

Artificial Intelligence · Computer Science 2023-10-17 Tristan Beolet , Alice Adenis , Erik Huneker , Maxime Louis
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