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A model of multicellular systems with several types of cells is developed from the phase field model. The model is presented as a set of partial differential equations of the field variables, each of which expresses the shape of one cell.…

Biological Physics · Physics 2015-05-30 Makiko Nonomura

The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dynamics and…

Tissues and Organs · Quantitative Biology 2025-06-03 Monika Sanoria , Gema Malet-Engra , Giorgio Scita , Nir Gov , Ajay Gopinathan

From scaling arguments and numerical simulations, we investigate the properties of the generalized elastic model (GEM), that is used to describe various physical systems such as polymers, membranes, single-file systems, or rough interfaces.…

Statistical Mechanics · Physics 2013-08-28 Mohsen Ghasemi Nezhadhaghighi , Aleksei V. Chechkin , Ralf Metzler

Chemical signaling is one of the ubiquitous mechanisms by which inter-cellular communication takes place at the microscopic level, particularly via chemotaxis. Such multi-cellular systems are popularly studied using continuum, mean-field…

Cell Behavior · Quantitative Biology 2009-11-11 Ramon Grima

We propose a three dimensional mechanical model of embryonic tissue dynamics. Mechanically coupled adherent cells are represented as particles interconnected with elastic beams which can exert non-central forces and torques. Tissue…

Biological Physics · Physics 2015-06-22 Andras Czirok , Dona Greta Isai

We introduce a model for translational molecular motors to demonstrate that a multivalent catalytic walker with flexible, uncoordinated legs can transform the free energy of surface-bound substrate sites into mechanical work and undergo…

Biological Physics · Physics 2014-11-18 Mark J. Olah , Darko Stefanovic

This study integrates pedestrian flow characteristics to formulate a mesoscopic cellular automata model tailored for simulating evacuations in large-scale scenarios. Departing from the conventional planar grid cell division, the model…

Physics and Society · Physics 2023-11-20 Wei Lv , Jinghui Wang , Zhiming Fang , Dun Mao

We analyze the Glauber dynamics for a bi-populated Curie-Weiss model. We obtain the limiting behavior of the empirical averages in the limit of infinitely many particles. We then characterize the phase space of the model in absence of…

Probability · Mathematics 2015-06-22 Francesca Collet

Animals use various processes to inform themselves about their environment and make decisions about how to move and form their territory. In some cases, populations inform themselves of competing groups through observations at distances,…

Populations and Evolution · Quantitative Biology 2022-11-17 Erin Ellefsen , Nancy Rodriguez

Cell movement, for example during embryogenesis or tumor metastasis, is a complex dynamical process resulting from an intricate interplay of multiple components of the cellular migration machinery. At first sight, the paths of migrating…

Cell Behavior · Quantitative Biology 2009-04-17 Peter Dieterich , Rainer Klages , Roland Preuss , Albrecht Schwab

Using molecular dynamics simulations, we determine the linear and nonlinear viscoelastic properties of a model polymer melt in the unentangled regime. Several approaches are compared for the computation of linear moduli, including…

Materials Science · Physics 2007-05-23 Mihail Vladkov , J. -L. Barrat

The method of molecular dynamics is used to study behavior of a ultracold non-ideal ion-electron Be plasma in a uniform magnetic field. Our simulations yield an estimate for the rate of electron-ion collisions which is…

Plasma Physics · Physics 2018-01-17 I. L. Isaev , A. P. Gavriliuk

The current paper is to investigate the numerical approximation of logistic type chemotaxis models in one space dimension with a free boundary. Such a model with a free boundary describes the spreading of a new or invasive species subject…

Numerical Analysis · Mathematics 2019-07-16 Lei Yang , Lianzhang Bao

We study the critical thresholds for the compressible pressureless Euler equations with pairwise attractive or repulsive interaction forces and non-local alignment forces in velocity in one dimension. We provide a complete description for…

Analysis of PDEs · Mathematics 2015-05-26 José A. Carrillo , Young-Pil Choi , Eitan Tadmor , Changhui Tan

The study of cells' dynamical properties is essential to a better understanding of several physiological processes. These properties are directly associated with cells' mechanical parameters experimentally achieved through physical stress.…

Soft Condensed Matter · Physics 2022-01-26 G. Ourique , E. F. Teixeira , L. G. Brunnet

Modeling and simulation of disease spreading in pedestrian crowds has been recently become a topic of increasing relevance. In this paper, we consider the influence of the crowd motion in a complex dynamical environment on the course of…

Dynamical Systems · Mathematics 2021-01-06 Parveena Samim Abdul Salam , Wolfgang Bock , Axel Klar , Sudarshan Tiwari

We present a general formalism able to derive the kinetic equations of polymer dynamics. It is based on the application of nonequilibrium thermodynamics to analyze the irreversible processes taking place in the conformational space of the…

Soft Condensed Matter · Physics 2009-11-07 J. M. Rubi , A. Perez-Madrid

Chemotaxis enables cells to systematically approach distant targets that emit a diffusible guiding substance. However, the visual observation of an encounter between a cell and a target does not necessarily indicate the presence of a…

Quantitative Methods · Quantitative Biology 2021-06-22 Claus Metzner , Franziska Hörsch , Christoph Mark , Tina Czerwinski , Alexander Winterl , Caroline Voskens , Ben Fabry

Dense monolayers of living cells display intriguing relaxation dynamics, reminiscent of soft and glassy materials close to the jamming transition, and migrate collectively when space is available, as in wound healing or in cancer invasion.…

This paper deals with the micro-macro derivation of virus models coupled with a reaction diffusion models that generates the dynamics in space of the virus particles. The first part of the presentation focuses, starting from [5, 6] on a…

Dynamical Systems · Mathematics 2021-12-15 Diletta Burini , Nadia Chouhad