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The relation between large-scale brain structure and function is an outstanding open problem in neuroscience. We approach this problem by studying the dynamical regime under which realistic spatio-temporal patterns of brain activity emerge…

Neurons and Cognition · Quantitative Biology 2014-05-27 Ariel Haimovici , Enzo Tagliazucchi , Pablo Balenzuela , Dante R. Chialvo

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

Quantitative Methods · Quantitative Biology 2016-02-03 Sean L. Simpson , Paul J. Laurienti

The human brain forms functional networks on all spatial scales. Modern fMRI scanners allow to resolve functional brain data in high resolutions, allowing to study large-scale networks that relate to cognitive processes. The analysis of…

Neurons and Cognition · Quantitative Biology 2019-05-14 Melanie Weber , Johannes Stelzer , Emil Saucan , Alexander Naitsat , Gabriele Lohmann , Jürgen Jost

The brain is a complex organ characterized by heterogeneous patterns of structural connections supporting unparalleled feats of cognition and a wide range of behaviors. New noninvasive imaging techniques now allow these patterns to be…

Neurons and Cognition · Quantitative Biology 2020-04-03 Christopher W. Lynn , Danielle S. Bassett

Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…

Quantitative Methods · Quantitative Biology 2020-03-20 Shikuang Deng , Shi Gu

Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this…

Neurons and Cognition · Quantitative Biology 2017-01-10 Nahuel Lascano , Guillermo Gallardo , Rachid Deriche , Dorian Mazauric , Demian Wassermann

We propose a framework for jointly modeling the geometry and functionality in high dimensional functional surfaces. The proposed mixed effects model characterizes effects of subject-specific covariates and exogenous stimuli on functional…

Applications · Statistics 2023-02-10 Jingjing Zou , Chi-Hua Chen , John A. D. Aston

Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data. Here, we discuss recent work using…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , Johan Nakuci , Sarah Feldt Muldoon

Representation of brain network interactions is fundamental to the translation of neural structure to brain function. As such, methodologies for mapping neural interactions into structural models, i.e., inference of functional connectome…

Neurons and Cognition · Quantitative Biology 2022-03-18 Rahul Biswas , Eli Shlizerman

Edge time series are increasingly used in brain functional imaging to study the node functional connectivity (nFC) dynamics at the finest temporal resolution while avoiding sliding windows. Here, we lay the mathematical foundations for the…

Neurons and Cognition · Quantitative Biology 2022-07-15 Leonardo Novelli , Adeel Razi

Dynamic functional connectivity (DFC) analysis involves measuring correlated neural activity over time across multiple brain regions. Significant regional correlations among neural signals, such as those obtained from resting-state…

A key question in modern neuroscience is how cognitive changes in a human brain can be quantified and captured by functional connectomes (FC) . A systematic approach to measure pairwise functional distance at different brain states is…

Neurons and Cognition · Quantitative Biology 2018-09-26 Enrico Amico , Alex Arenas , Joaquin Goni

Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent technical and methodological progress in neuroimaging has helped…

Neurons and Cognition · Quantitative Biology 2015-05-01 Ibai Diez , Paolo Bonifazi , Iñaki Escudero , Beatriz Mateos , Miguel A. Muñoz , Sebastiano Stramaglia , Jesus M. Cortes

Several approaches to cognition and intelligence research rely on statistics-based models testing, namely factor analysis. In the present work we exploit the emerging dynamical systems perspective putting the focus on the role of the…

Physics and Society · Physics 2018-03-15 Gemma Rosell-Tarragó , Emanuele Cozzo , Albert Díaz-Guilera

Functional connectivity refers to the temporal statistical relationship between spatially distinct brain regions and is usually inferred from the time series coherence/correlation in brain activity between regions of interest. In human…

Machine Learning · Statistics 2015-03-02 Shaurabh Nandy , Richard M. Golden

Functional connectivity (FC) has been widely used to study brain network interactions underlying the emerging cognition and behavior of an individual. FC is usually defined as the correlation or partial correlation between brain regions.…

Applications · Statistics 2020-10-27 Gemeng Zhang , Aiying Zhang , Biao Cai , Zhuozhuo Tu , Vince D. Calhoun , Yu-Ping Wang

Brain can be represented as a network, where regions are the nodes and relations between the regions are edges. Within a network, co-existence of cooperative and competitive relationships between different nodes is called coopetition.…

Neurons and Cognition · Quantitative Biology 2018-02-13 Subhadip Paul , Satyam Mukherjee , Sagnik Bhattacharyya

Brain gender differences have been known for a long time and are the possible reason for many psychological, psychiatric and behavioral differences between males and females. Predicting genders from brain functional connectivity (FC) can…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Gengyan Zhao , Gyujoon Hwang , Cole J. Cook , Fang Liu , Mary E. Meyerand , Rasmus M. Birn

We utilize a model of Wilson-Cowan oscillators to investigate structure-function relationships in the human brain by means of simulations of the spontaneous dynamics of brain networks generated through human connectome data. This allows us…

Neurons and Cognition · Quantitative Biology 2023-06-14 Youssef Kora , Salma Salhi , Jörn Davidsen , Christoph Simon

At the macroscale, the brain operates as a network of interconnected neuronal populations, which display rhythmic dynamics that support interareal communication. Understanding how stimulation of a particular brain area impacts such…

Neurons and Cognition · Quantitative Biology 2020-11-12 Lia Papadopoulos , Christopher W. Lynn , Demian Battaglia , Danielle S. Bassett