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State estimators often provide self-assessed uncertainty metrics, such as covariance matrices, whose credibility is critical for downstream tasks. However, these self-assessments can be misleading due to underlying modeling violations like…

Signal Processing · Electrical Eng. & Systems 2026-04-02 Penggao Yan , Xingqun Zhan , Rui Sun , Li-Ta Hsu

In this article, an efficient sequential linear programming algorithm (SLP) for uncertainty analysis-based data-driven computational mechanics (UA-DDCM) is presented. By assuming that the uncertain constitutive relationship embedded behind…

Optimization and Control · Mathematics 2022-11-09 Mengcheng Huang , Chang Liu , Zongliang Du , Shan Tang , Xu Guo

Recent advances in medical imaging techniques have led to significant improvements in the management of prostate cancer (PCa). In particular, multi-parametric MRI (mp-MRI) continues to gain clinical acceptance as the preferred imaging…

Image and Video Processing · Electrical Eng. & Systems 2019-10-08 Ruiming Cao , Xinran Zhong , Fabien Scalzo , Steven Raman , Kyung hyun Sung

Raman spectroscopy's capability to provide meaningful composition predictions is heavily reliant on a pre-processing step to remove insignificant spectral variation. This is crucial in biofluid analysis. Widespread adoption of diagnostics…

Signal Processing · Electrical Eng. & Systems 2019-04-05 Emily E Storey , Amr S. Helmy

Machine learning (ML) techniques are increasingly applied to decision-making and control problems in Cyber-Physical Systems among which many are safety-critical, e.g., chemical plants, robotics, autonomous vehicles. Despite the significant…

Systems and Control · Electrical Eng. & Systems 2019-09-12 Xiaozhe Gu , Arvind Easwaran

Machine Learning (ML) is increasingly used to implement advanced applications with non-deterministic behavior, which operate on the cloud-edge continuum. The pervasive adoption of ML is urgently calling for assurance solutions assessing…

Machine Learning · Computer Science 2023-10-24 Marco Anisetti , Claudio A. Ardagna , Nicola Bena , Ernesto Damiani

Lack of reliability is a well-known issue for reinforcement learning (RL) algorithms. This problem has gained increasing attention in recent years, and efforts to improve it have grown substantially. To aid RL researchers and production…

Machine Learning · Statistics 2020-02-14 Stephanie C. Y. Chan , Samuel Fishman , John Canny , Anoop Korattikara , Sergio Guadarrama

Image registration is an important tool for medical image analysis and is used to bring images into the same reference frame by warping the coordinate field of one image, such that some similarity measure is minimized. We study similarity…

Computer Vision and Pattern Recognition · Computer Science 2015-03-20 Sune Darkner , Jon Sporring

The performance of learning-based algorithms improves with the amount of labelled data used for training. Yet, manually annotating data is particularly difficult for medical image segmentation tasks because of the limited expert…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Mélanie Gaillochet , Christian Desrosiers , Hervé Lombaert

Background: Clinical trials rely on transparent inclusion criteria to ensure generalizability. In contrast, benchmarks validating health-related large language models (LLMs) rarely characterize the "patient" or "query" populations they…

Artificial Intelligence · Computer Science 2026-04-17 Alvin Rajkomar , Pavan Sudarshan , Angela Lai , Lily Peng

Magnetic resonance imaging (MRI) data is heterogeneous due to differences in device manufacturers, scanning protocols, and inter-subject variability. A conventional way to mitigate MR image heterogeneity is to apply preprocessing…

Image and Video Processing · Electrical Eng. & Systems 2023-10-24 Ekaterina Kondrateva , Polina Druzhinina , Alexandra Dalechina , Svetlana Zolotova , Andrey Golanov , Boris Shirokikh , Mikhail Belyaev , Anvar Kurmukov

In this paper, we study the problem of uncertainty estimation and calibration for LLMs. We begin by formulating the uncertainty estimation problem, a relevant yet underexplored area in existing literature. We then propose a supervised…

Machine Learning · Computer Science 2024-10-24 Linyu Liu , Yu Pan , Xiaocheng Li , Guanting Chen

Noisy labels are a pervasive challenge in medical image classification, where annotation errors arise from inter-observer variability and diagnostic ambiguity. Although several noise-robust learning methods have been proposed, their…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Maycon R. S. Pereira , Filipe R. Cordeiro

CT and MRI are two of the most informative modalities in spinal diagnostics and treatment planning. CT is useful when analysing bony structures, while MRI gives information about the soft tissue. Thus, fusing the information of both…

Context: Conducting experiments is central to research machine learning research to benchmark, evaluate and compare learning algorithms. Consequently it is important we conduct reliable, trustworthy experiments. Objective: We investigate…

The deployment of Large Language Models in Medical Question Answering is severely hampered by ambiguous user queries, a significant safety risk that demonstrably reduces answer accuracy in high-stakes healthcare settings. In this paper, we…

Computation and Language · Computer Science 2026-01-27 Yaokun Liu , Yifan Liu , Phoebe Mbuvi , Zelin Li , Ruichen Yao , Gawon Lim , Dong Wang

Reliable quantification of uncertainty in Mobile Laser Scanning (MLS) point clouds is essential for ensuring the accuracy and credibility of downstream applications such as 3D mapping, modeling, and change analysis. Traditional backward…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Ziyang Xu , Olaf Wysocki , Christoph Holst

Anomaly detection and localization in medical imaging remain critical challenges in healthcare. This paper introduces Spatial-MSMA (Multiscale Score Matching Analysis), a novel unsupervised method for anomaly localization in volumetric…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Ahsan Mahmood , Junier Oliva , Martin Styner

Robust learning is an important issue in Scientific Machine Learning (SciML). There are several works in the literature addressing this topic. However, there is an increasing demand for methods that can simultaneously consider all the…

Many problems in science and engineering require uncertainty quantification that accounts for observed data. For example, in computational neuroscience, Neural Population Models (NPMs) are mechanistic models that describe brain physiology…

Computation · Statistics 2020-08-04 Philip Maybank , Patrick Peltzer , Uwe Naumann , Ingo Bojak