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Diagnostic investigation has an important role in risk stratification and clinical decision making of patients with suspected and documented Coronary Artery Disease (CAD). However, the majority of existing tools are primarily focused on the…

Cerebral aneurysm progression is a result of a complex interplay of the biomechanical and clinical risk factors that drive aneurysmal growth and rupture. Subjects with multiple aneurysms are unique cases wherein clinical risk factors are…

Medical Physics · Physics 2022-12-26 Tanmay C. Shidhore , Aaron A. Cohen-Gadol , Vitaliy L. Rayz , Ivan C. Christov

We hereby present a full synthetic model, able to mimic the various constituents of the cerebral vascular tree: the cerebral arteries, the bifurcations and the intracranial aneurysms. By building this model, our goal was to provide a…

Image and Video Processing · Electrical Eng. & Systems 2024-03-28 Rafic Nader , Florent Autrusseau , Vincent L'Allinec , Romain Bourcier

Bicuspid aortic valve is the most common congenital heart defect, affecting 1-2% of the global population. Patients with bicuspid valves frequently develop dilation and aneurysms of the ascending aorta. Both hemodynamic and genetic factors…

Tissues and Organs · Quantitative Biology 2022-08-26 Alexander D. Kaiser , Rohan Shad , Nicole Schiavone , William Hiesinger , Alison L. Marsden

Aortic shape analysis plays a key role in cardiovascular diagnostics, treatment planning, and understanding disease progression. We present a robust, fully automated pipeline for aortic shape analysis from cardiac MRI, combining deep…

Tissues and Organs · Quantitative Biology 2025-09-15 Nairouz Shehata , Amr Elsawy , Mohamed Nagy , Muhammad ElMahdy , Mariam Ali , Soha Romeih , Heba Aguib , Magdi Yacoub , Ben Glocker

Objective: we propose a procedure for calibrating 4 parameters governing the mechanical boundary conditions (BCs) of a thoracic aorta (TA) model derived from one patient with ascending aortic aneurysm. The BCs reproduce the visco-elastic…

This study investigated the potential of end-to-end deep learning tools as a more effective substitute for FEM in predicting stress-strain fields within 2D cross sections of arterial wall. We first proposed a U-Net based fully convolutional…

Machine Learning · Computer Science 2023-08-04 Yasin Shokrollahi1 , Pengfei Dong1 , Xianqi Li , Linxia Gu

The automatic analysis of ultrasound sequences can substantially improve the efficiency of clinical diagnosis. In this work we present our attempt to automate the challenging task of measuring the vascular diameter of the fetal abdominal…

Computer Vision and Pattern Recognition · Computer Science 2018-07-12 Nicolo' Savioli , Silvia Visentin , Erich Cosmi , Enrico Grisan , Pablo Lamata , Giovanni Montana

An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta which, if left untreated, can progressively widen and may rupture with fatal consequences. In this paper, we determine an optimal treatment policy using Markov…

Systems and Control · Computer Science 2016-11-08 Robert Mattila , Antti Siika , Joy Roy , Bo Wahlberg

Computational models are continuously integrated in the clinical space, where they support clinicians in disease diagnosis, prognosis, and prevention strategies. While assisting in clinical space, these computational models frequently use…

Medical Physics · Physics 2026-04-30 Muhammad Usman , Peter N. Castillo , Akil Narayan , Lucas H. Timmins

Intrasaccular flow disruptors treat cerebral aneurysms by diverting the blood flow from the aneurysm sac. Residual flow into the sac after the intervention is a failure that could be due to the use of an undersized device, or to vascular…

Image and Video Processing · Electrical Eng. & Systems 2022-11-23 Ashutosh Jadhav , Satyananda Kashyap , Hakan Bulu , Ronak Dholakia , Amon Y. Liu , Tanveer Syeda-Mahmood , William R. Patterson , Hussain Rangwala , Mehdi Moradi

We analyse and compare various empirical models of wall pressure spectra beneath turbulent boundary layers and propose an alternative machine learning approach using Artificial Neural Networks (ANN). The analysis and the training of the ANN…

Fluid Dynamics · Physics 2022-03-14 J. Dominique , J. Van den Berghe , C. Schram , M. A. Mendez

Inhomogeneities in the aortic wall can lead to localized stress accumulations, possibly initiating dissection. In many cases, a dissection results from pathological changes such as fragmentation or loss of elastic fibers. But it has been…

Computed tomography image segmentation of complex abdominal aortic aneurysms (AAA) often fails because the models assign internal focus to irrelevant structures or do not focus on thin, low-contrast targets. Where the model looks is the…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Abu Noman Md Sakib , Merjulah Roby , Zijie Zhang , Satish Muluk , Mark K. Eskandari , Ender A. Finol

Numerical simulations to evaluate thoracic aortic hemodynamics include a computational fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD neglects the arterial deformation along the cardiac cycle by…

Perturbations to the homeostatic distribution of mechanical forces exerted by blood on the endothelial layer have been correlated with vascular pathologies including intracranial aneurysms and atherosclerosis. Recent computational work…

Computational Engineering, Finance, and Science · Computer Science 2014-08-05 Miguel O. Bernabeu , Rupert W. Nash , Derek Groen , Hywel B. Carver , James Hetherington , Timm Krüger , Peter V. Coveney

We propose a deep learning method to model and generate synthetic aortic shapes based on representing shapes as the zero-level set of a neural signed distance field, conditioned by a family of trainable embedding vectors with encode the…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Andrei Gasparovici , Alex Serban

The analysis of quantitative hemodynamics and luminal pressure may add valuable information to aid treatment strategies and prognosis for aortic dissections. This work directly compared in vitro 4D-flow magnetic resonance imaging (MRI),…

This study applies convolutional neural network (CNN)-based automatic segmentation and distensibility measurement of the ascending and descending aorta from 2D phase-contrast cine magnetic resonance imaging (PC-cine MRI) within the large…

One of the most important subjects of hydraulic engineering is the reliable estimation of the transverse distribution in the rectangular channel of bed and wall shear stresses. This study makes use of the Tsallis entropy, genetic…

Fluid Dynamics · Physics 2021-03-10 Babak Lashkar-Ara , Niloofar Kalantari , Zohreh Sheikh Khozani , Amir Mosavi
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