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Medical image segmentation supports clinical workflows by precisely delineating anatomical structures and lesions. However, medical image datasets medical image datasets suffer from acquisition noise and annotation ambiguity, causing…

Artificial Intelligence · Computer Science 2026-04-14 Ruiyang Li , Fang Liu , Licheng Jiao , Xinglin Xie , Jiayao Hao , Shuo Li , Xu Liu , Jingyi Yang , Lingling Li , Puhua Chen , Wenping Ma

Uncertainty quantification in medical images has become an essential addition to segmentation models for practical application in the real world. Although there are valuable developments in accurate uncertainty quantification methods using…

Image and Video Processing · Electrical Eng. & Systems 2023-05-02 Christiaan G. A. Viviers , Amaan M. M. Valiuddin , Peter H. N. de With , Fons van der Sommen

Quantifying uncertainty in medical image segmentation applications is essential, as it is often connected to vital decision-making. Compelling attempts have been made in quantifying the uncertainty in image segmentation architectures, e.g.…

Computer Vision and Pattern Recognition · Computer Science 2021-08-06 M. M. A. Valiuddin , C. G. A. Viviers , R. J. G. van Sloun , P. H. N. de With , F. van der Sommen

Despite the remarkable progress in generative modelling, current diffusion models lack a quantitative approach to assess image quality. To address this limitation, we propose to estimate the pixel-wise aleatoric uncertainty during the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Michele De Vita , Vasileios Belagiannis

Equipping predicted segmentation with calibrated uncertainty is essential for safety-critical applications. In this work, we focus on capturing the data-inherent uncertainty (aka aleatoric uncertainty) in segmentation, typically when…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Zhitong Gao , Yucong Chen , Chuyu Zhang , Xuming He

Generative models have achieved remarkable progress with the emergence of flow matching (FM). It has demonstrated strong generative capabilities and attracted significant attention as a simulation-free flow-based framework capable of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Huynh Trinh Ngoc , Hoang Anh Nguyen Kim , Toan Nguyen Hai , Long Tran Quoc

Medical image segmentation is inherently an ambiguous task due to factors such as partial volumes and variations in anatomical definitions. While in most cases the segmentation uncertainty is around the border of structures of interest,…

Machine Learning · Statistics 2020-08-05 Raghavendra Selvan , Frederik Faye , Jon Middleton , Akshay Pai

In safety-critical applications like medical diagnosis, certainty associated with a model's prediction is just as important as its accuracy. Consequently, uncertainty estimation and reduction play a crucial role. Uncertainty in predictions…

Image and Video Processing · Electrical Eng. & Systems 2023-09-12 Abhishek Singh Sambyal , Narayanan C. Krishnan , Deepti R. Bathula

Despite the state-of-the-art performance for medical image segmentation, deep convolutional neural networks (CNNs) have rarely provided uncertainty estimations regarding their segmentation outputs, e.g., model (epistemic) and image-based…

Computer Vision and Pattern Recognition · Computer Science 2019-02-12 Guotai Wang , Wenqi Li , Michael Aertsen , Jan Deprest , Sebastien Ourselin , Tom Vercauteren

In image segmentation, there is often more than one plausible solution for a given input. In medical imaging, for example, experts will often disagree about the exact location of object boundaries. Estimating this inherent uncertainty and…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Miguel Monteiro , Loïc Le Folgoc , Daniel Coelho de Castro , Nick Pawlowski , Bernardo Marques , Konstantinos Kamnitsas , Mark van der Wilk , Ben Glocker

Aleatoric uncertainty quantification seeks for distributional knowledge of random responses, which is important for reliability analysis and robustness improvement in machine learning applications. Previous research on aleatoric uncertainty…

Machine Learning · Computer Science 2022-06-10 Ziyi Huang , Henry Lam , Haofeng Zhang

The performance of learning-based algorithms improves with the amount of labelled data used for training. Yet, manually annotating data is particularly difficult for medical image segmentation tasks because of the limited expert…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Mélanie Gaillochet , Christian Desrosiers , Hervé Lombaert

Reliable medical image classification requires accurate predictions and well-calibrated uncertainty estimates, especially in high-stakes clinical settings. This work presents MedSymmFlow, a generative-discriminative hybrid model built on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Francisco Caetano , Lemar Abdi , Christiaan Viviers , Amaan Valiuddin , Fons van der Sommen

We address the selection and evaluation of uncertain segmentation methods in medical imaging and present two case studies: prostate segmentation, illustrating that for minimal annotator variation simple deterministic models can suffice, and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-24 Kilian Zepf , Jes Frellsen , Aasa Feragen

Collective insights from a group of experts have always proven to outperform an individual's best diagnostic for clinical tasks. For the task of medical image segmentation, existing research on AI-based alternatives focuses more on…

Computer Vision and Pattern Recognition · Computer Science 2023-04-11 Aimon Rahman , Jeya Maria Jose Valanarasu , Ilker Hacihaliloglu , Vishal M Patel

Distribution-to-distribution generative models support scientific imaging tasks ranging from modeling cellular perturbation responses to translating medical images across conditions. Trustworthy generation requires reliability, or…

Machine Learning · Computer Science 2026-05-22 Dongxia Wu , Yuhui Zhang , Serena Yeung-Levy , Emma Lundberg , Emily B. Fox

Despite the remarkable success of sampling-based generative models such as flow matching, they can still produce samples of inconsistent or degraded quality. To assess sample reliability and generate higher-quality outputs, we propose…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Juyeop Han , Lukas Lao Beyer , Sertac Karaman

Flow matching has recently emerged as a principled framework for learning continuous-time transport maps, enabling efficient ODE-based sampling without relying on stochastic diffusion processes. While generative modeling has shown promise…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Zhi Chen , Runze Hu , Le Zhang

Data uncertainties, such as sensor noise, occlusions or limitations in the acquisition method can introduce irreducible ambiguities in images, which result in varying, yet plausible, semantic hypotheses. In Machine Learning, this ambiguity…

Computer Vision and Pattern Recognition · Computer Science 2024-08-21 M. M. Amaan Valiuddin , Christiaan G. A. Viviers , Ruud J. G. van Sloun , Peter H. N. de With , Fons van der Sommen

Medical image segmentation plays an important role in accurately identifying and isolating regions of interest within medical images. Generative approaches are particularly effective in modeling the statistical properties of segmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-02-06 Lea Bogensperger , Dominik Narnhofer , Alexander Falk , Konrad Schindler , Thomas Pock
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