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In this study, we present a comprehensive numerical analysis of blood flow within human left ventricle models, with particular emphasis on optimizing simulation conditions to enhance the realism and computational efficiency of heart flow…

The heart is the central part of the cardiovascular network. Its role is to pump blood to various body organs. Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications…

Medical Physics · Physics 2024-11-19 Mahesh S. Nagargoje , Eneko Lazpita , Jesús Garicano-Mena , Soledad Le Clainche

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. The contraction and relaxation of left ventricle (LV) is the main driving force of blood circulation. Altered LV hemodynamics is believed to be associated with…

Medical Physics · Physics 2019-11-04 Fanwei Kong , Christoph Augustin , Kevin Sack , Shawn Shadden

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

Vortical blood flow in the human left ventricular (LV) inflow initiates from the mitral valve (MV) and evolves within the LV during diastolic E-filling. Hence, vortical flow links MV and LV hemodynamics. This study sought to elucidate and…

The present focus of heart flow studies is largely based on flow within the left ventricle and how this flow changes when subject to disease. However, despite recent advancements, a simple tractable model of even healthy left ventricular…

Fluid Dynamics · Physics 2019-03-18 Giuseppe Di Labbio , Lyes Kadem

We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging…

Fluid Dynamics · Physics 2015-05-30 Trung Le , Fotis Sotiropoulos , Dane Coffey , Daniel Keefe

Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is…

The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data…

Fluid Dynamics · Physics 2014-07-29 S. Fortini , G. Querzoli , S. Espa , A. Cenedese

Studying and interpreting the different flow patterns present in urban areas is becoming essential since they help develop new approaches to fight climate change through an improved understanding of the dynamics of the pollutants in urban…

Computer modeling can provide quantitative insight into cardiac fluid dynamics phenomena that are not evident from standard imaging tools. We propose a new approach to modeling left ventricle fluid dynamics based on an image-driven…

Understanding flow structures in urban areas is widely recognized as a challenging concern due to its effect on urban development, air quality, and pollutant dispersion. In this study, state-of-the-art data-driven methods for modal analysis…

Modal decomposition techniques are important tools for the analysis of unsteady flows and, in order to provide meaningful insights with respect to coherent structures and their characteristic frequencies, the modes must possess a robust…

Fluid Dynamics · Physics 2023-08-24 Lucas F. de Souza , Renato F. Miotto , William R. Wolf

Segmentation of the left ventricle (LV) from cardiac magnetic resonance imaging (MRI) datasets is an essential step for calculation of clinical indices such as ventricular volume and ejection fraction. In this work, we employ deep learning…

Computer Vision and Pattern Recognition · Computer Science 2015-12-29 M. R. Avendi , A. Kheradvar , H. Jafarkhani

Proper heart morphogenesis requires a delicate balance between hemodynamic forces, myocardial activity, morphogen gradients, and epigenetic signaling, all of which are coupled with genetic regulatory networks. Recently both in vivo and in…

Tissues and Organs · Quantitative Biology 2018-09-19 Nicholas A. Battista , Dylan R. Douglas , Andrea N. Lane , Leigh Ann Samsa , Jiandong Liu , Laura A. Miller

Turbulent flow profiles are known to change between low- (LDR) and high-extent drag reduction (HDR) regimes. It is however not until recently that the LDR-HDR transition is recognized as a fundamental change between two DR mechanisms.…

Fluid Dynamics · Physics 2019-12-31 Lu Zhu , Li Xi

Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Fanwei Kong , Aaron Brown , Michael Loecher , Perry S. Choi , Lei Shi , Michael Ma , Daniel B. Ennis , Alison Marsden

Currently, it is challenging to investigate aneurismal hemodynamics based on current in-vivo data such as Magnetic Resonance Imaging or Computed Tomography due to the limitations in both spatial and temporal resolutions. In this work, we…

Fluid Dynamics · Physics 2024-10-17 Thien-Tam Nguyen , Davina Kasperski , Phat Kim Huynh , Trung Quoc Le , Trung Bao Le

Background: Despite the significant advances made in the field of computational fluid dynamics (CFD) to simulate the left atrium (LA) in atrial fibrillation (AF) conditions, the connection between atrial structure, flow dynamics, and blood…

Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…

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