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Deep learning has emerged as a promising paradigm to give access to highly accurate predictions of molecular and materials properties. A common short-coming shared by current approaches, however, is that neural networks only give point…

Computational Physics · Physics 2023-05-10 Albert Zhu , Simon Batzner , Albert Musaelian , Boris Kozinsky

Universal Machine Learning Interactomic Potentials (MLIPs) enable accelerated simulations for materials discovery. However, current research efforts fail to impactfully utilize MLIPs due to: 1. Overreliance on Density Functional Theory…

Materials Science · Physics 2025-02-07 Santiago Miret , Kin Long Kelvin Lee , Carmelo Gonzales , Sajid Mannan , N. M. Anoop Krishnan

The quality of machine learning interatomic potentials (MLIPs) strongly depends on the quantity of training data as well as the quantum chemistry (QC) level of theory used. Datasets generated with high-fidelity QC methods are typically…

Interatomic potentials are key to uncovering microscopic structure-property relationships, essential for multiscale simulations and high-throughput experiments. For metallic glasses, their disordered atomic structure makes the development…

As instruction-tuned large language models (LLMs) evolve, aligning pretrained foundation models presents increasing challenges. Existing alignment strategies, which typically leverage diverse and high-quality data sources, often overlook…

Computation and Language · Computer Science 2024-06-10 Yikun Wang , Rui Zheng , Liang Ding , Qi Zhang , Dahua Lin , Dacheng Tao

An accurate description of information is relevant for a range of problems in atomistic machine learning (ML), such as crafting training sets, performing uncertainty quantification (UQ), or extracting physical insights from large datasets.…

Materials Science · Physics 2025-05-02 Daniel Schwalbe-Koda , Sebastien Hamel , Babak Sadigh , Fei Zhou , Vincenzo Lordi

Understanding and quantifying uncertainty in black box Neural Networks (NNs) is critical when deployed in real-world settings such as healthcare. Recent works using Bayesian and non-Bayesian methods have shown how a unified predictive…

Machine Learning · Computer Science 2020-09-29 Utkarsh Sarawgi , Wazeer Zulfikar , Rishab Khincha , Pattie Maes

Machine learned interatomic potentials (MLIPs) have emerged as powerful tools for molecular dynamics (MD) simulations with their competitive accuracy and computational efficiency. However, MLIPs are often observed to exhibit un-physical…

Materials Science · Physics 2026-02-24 Qianyu Zheng , Victor Fung

Estimating and disentangling epistemic uncertainty, uncertainty that is reducible with more training data, and aleatoric uncertainty, uncertainty that is inherent to the task at hand, is critically important when applying machine learning…

Machine Learning · Computer Science 2024-11-08 Matthew A. Chan , Maria J. Molina , Christopher A. Metzler

Despite their capabilities, Multimodal Large Language Models (MLLMs) may produce plausible but erroneous outputs, hindering reliable deployment. Accurate uncertainty metrics could enable escalation of unreliable queries to human experts or…

Artificial Intelligence · Computer Science 2026-03-02 Gregory Kang Ruey Lau , Hieu Dao , Nicole Kan Hui Lin , Bryan Kian Hsiang Low

Deep neural networks lack interpretability and tend to be overconfident, which poses a serious problem in safety-critical applications like autonomous driving, medical imaging, or machine vision tasks with high demands on reliability.…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Steven Landgraf , Kira Wursthorn , Markus Hillemann , Markus Ulrich

Machine-learned interatomic potentials (MLIPs) and force fields (i.e. interaction laws for atoms and molecules) are typically trained on limited data-sets that cover only a very small section of the full space of possible input structures.…

Numerical Analysis · Mathematics 2022-09-13 Christoph Ortner , Yangshuai Wang

Deep learning is increasingly being applied in safety-critical domains. For these scenarios it is important to know the level of uncertainty in a model's prediction to ensure appropriate decisions are made by the system. Deep ensembles are…

Machine Learning · Computer Science 2022-03-17 Yassir Fathullah , Mark J. F. Gales

Machine learning interatomic potentials (MLIPs) are routinely used to model diverse atomistic phenomena, yet parameterizing them to accurately capture solid-state phase transformations remains difficult. We present error metrics and…

Materials Science · Physics 2026-01-21 Lorenzo Piersante , Anirudh Raju Natarajan

Universal machine learning force fields (UMLFFs) promise to revolutionize materials science by enabling rapid atomistic simulations across the periodic table. However, their evaluation has been limited to computational benchmarks that may…

The hybrid neural differentiable models mark a significant advancement in the field of scientific machine learning. These models, integrating numerical representations of known physics into deep neural networks, offer enhanced predictive…

Machine Learning · Computer Science 2024-01-02 Deepak Akhare , Tengfei Luo , Jian-Xun Wang

Machine learned interatomic potentials (MLIPs) are becoming a standard method for DFT-level accurate molecular dynamics simulation and large-scale studies of crystal energetics. Increasingly popular are universal pre-trained potentials,…

Materials Science · Physics 2026-02-03 Abhijith S Parackal , Rickard Armiento , Florian Trybel

Machine learning interatomic potentials (MLIPs) evaluate potential energy surfaces orders of magnitude faster while maintaining accuracy comparable to first-principles calculations, and universal MLIPs that cover most of the periodic table…

Chemical Physics · Physics 2026-03-04 Naoya Kuroda , Kenji Ishihara , Tomoya Shiota , Wataru Mizukami

Machine learning interatomic potentials (MLIPs) have become powerful tools to extend molecular simulations beyond the limits of quantum methods, offering near-quantum accuracy at much lower computational cost. Yet, developing reliable MLIPs…

Materials Science · Physics 2025-12-30 Adam Lahouari , Jutta Rogal , Mark E. Tuckerman

Large-scale atomistic simulations are essential to bridge computational materials and chemistry to realistic materials and drug discovery applications. In the past few years, rapid developments of machine learning interatomic potentials…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-03 Kevin Han , Bowen Deng , Amir Barati Farimani , Gerbrand Ceder
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