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The interaction between proteins and nucleic acids is crucial for processes that sustain cellular function, including DNA maintenance and the regulation of gene expression and translation. Amino acid mutations in protein-nucleic acid…

Biomolecules · Quantitative Biology 2025-12-01 Somnath Mondal , Tinkal Mondal , Soumajit Pramanik , Rukmankesh Mehra

While many diffusion models perform well when controlling particular aspects such as style, character, and interaction, they struggle with fine-grained control due to dataset limitations and intricate model architecture design. This paper…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Conghan Yue , Zhengwei Peng , Shiyan Du , Zhi Ji , Chuangjian Cai , Le Wan , Dongyu Zhang

In clinical practice, full imaging is not always feasible, often due to complex acquisition protocols, stringent privacy regulations, or specific clinical needs. However, missing MR modalities pose significant challenges for tasks like…

Computer Vision and Pattern Recognition · Computer Science 2025-01-23 Aghiles Kebaili , Jérôme Lapuyade-Lahorgue , Pierre Vera , Su Ruan

Ptychographic phase retrieval enables high-resolution imaging of complex samples but often suffers from artifacts such as grid pathology and multislice crosstalk, which degrade reconstructed images. We propose a plug-and-play (PnP)…

Graphics · Computer Science 2026-05-26 Ming Du , Volker Rose , Junjing Deng , Dileep Singh , Si Chen , Mathew J. Cherukara

Diffusion models promise efficient parallel text generation but rely on bidirectional attention, creating a structural mismatch with pre-trained Autoregressive (AR) models. This incompatibility precludes reusing robust AR priors,…

Computation and Language · Computer Science 2026-05-29 Xiangyu Ma , Teng Xiao , Zuchao Li , Lefei Zhang

In this work, we investigate hybrid PET reconstruction algorithms based on coupling a model-based variational reconstruction and the application of a separately learnt Deep Neural Network operator (DNN) in an ADMM Plug and Play framework.…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Florent Sureau , Mahdi Latreche , Marion Savanier , Claude Comtat

In practice, deep neural networks have been found to be vulnerable to various types of noise, such as adversarial examples and corruption. Various adversarial defense methods have accordingly been developed to improve adversarial robustness…

Machine Learning · Computer Science 2020-12-24 Aishan Liu , Xianglong Liu , Chongzhi Zhang , Hang Yu , Qiang Liu , Dacheng Tao

Consistency models (CMs) learn a consistent mapping from multiple noise levels to the data endpoint and can therefore perform generative inference in one or a few steps. This property makes them attractive as learned priors for low-latency…

Signal Processing · Electrical Eng. & Systems 2026-04-28 Jinlong Li , Peng Yang , Zehui Xiong , Xianbin Cao

Optimization is essential in deep learning. The foundational method upon which most optimizers are built is momentum-based stochastic gradient descent. However, it suffers from two key drawbacks. First, it has noisy and varying gradients,…

Machine Learning · Computer Science 2026-05-22 Saurabh Saini , Kapil Ahuja , Thomas Wick , Saurav Kumar

This paper presents a novel deformable registration framework, leveraging an image prior specified through a denoising function, for severely noise-corrupted placental images. Recent work on plug-and-play (PnP) priors has shown the…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Jiarui Xing , Ulugbek Kamilov , Wenjie Wu , Yong Wang , Miaomiao Zhang

Deep neural networks (DNNs) offer significant promise for improving breast cancer diagnosis in medical imaging. However, these models are highly susceptible to adversarial attacks--small, imperceptible changes that can mislead…

Computer Vision and Pattern Recognition · Computer Science 2024-12-16 Yasamin Medghalchi , Moein Heidari , Clayton Allard , Leonid Sigal , Ilker Hacihaliloglu

The plug-and-play (PnP) method uses a deep denoiser within a proximal algorithm for model-based image reconstruction (IR). Unlike end-to-end IR, PnP allows the same pretrained denoiser to be used across different imaging tasks, without the…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Arghya Sinha , Trishit Mukherjee , Kunal N. Chaudhury

We propose a posterior sampling algorithm for the problem of estimating multiple independent source signals from their noisy superposition. The proposed algorithm is a combination of Gibbs sampling method and plug-and-play (PnP) diffusion…

Signal Processing · Electrical Eng. & Systems 2025-09-17 Yi Zhang , Rui Guo , Yonina C. Eldar

We propose a new approach for large-scale high-dynamic range computational imaging. Deep Neural Networks (DNNs) trained end-to-end can solve linear inverse imaging problems almost instantaneously. While unfolded architectures provide…

Instrumentation and Methods for Astrophysics · Physics 2023-09-28 Amir Aghabiglou , Matthieu Terris , Adrian Jackson , Yves Wiaux

Diffusion models have emerged as a powerful foundation model for visual generations. With an appropriate sampling process, it can effectively serve as a generative prior for solving general inverse problems. Current posterior sampling-based…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Shijie Zhou , Huaisheng Zhu , Rohan Sharma , Jiayi Chen , Ruiyi Zhang , Kaiyi Ji , Changyou Chen

We propose a general deep plug-and-play (PnP) algorithm with a theoretical convergence guarantee. PnP strategies have demonstrated outstanding performance in various image restoration tasks by exploiting the powerful priors underlying…

Image and Video Processing · Electrical Eng. & Systems 2025-12-19 Yodai Suzuki , Ryosuke Isono , Shunsuke Ono

The emergence of generative AI and controllable diffusion has made image-to-image synthesis increasingly practical and efficient. However, when input images exhibit low entropy and sparse, the inherent characteristics of diffusion models…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Hao Wang , Xiwen Chen , Ashish Bastola , Jiayou Qin , Abolfazl Razi

While deep neural networks (NN) significantly advance image compressed sensing (CS) by improving reconstruction quality, the necessity of training current CS NNs from scratch constrains their effectiveness and hampers rapid deployment.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-04 Bin Chen , Zhenyu Zhang , Weiqi Li , Chen Zhao , Jiwen Yu , Shijie Zhao , Jie Chen , Jian Zhang

Solving ill-posed inverse problems requires careful formulation of prior beliefs over the signals of interest and an accurate description of their manifestation into noisy measurements. Handcrafted signal priors based on e.g. sparsity are…

Machine Learning · Computer Science 2025-08-14 Tristan S. W. Stevens , Hans van Gorp , Faik C. Meral , Junseob Shin , Jason Yu , Jean-Luc Robert , Ruud J. G. van Sloun

Parameter estimation remains a challenging task across many areas of engineering. Because data acquisition can often be costly, limited, or prone to inaccuracies (noise, uncertainty) it is crucial to identify sensor configurations that…

Machine Learning · Statistics 2025-11-20 Georgios Venianakis , Constantinos Theodoropoulos , Michail Kavousanakis
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