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Recent advancements in machine learning have significantly improved the identification of disease-associated genes from gene expression datasets. However, these processes often require extensive expertise and manual effort, limiting their…

Machine Learning · Computer Science 2025-04-09 Haoyang Liu , Shuyu Chen , Ye Zhang , Haohan Wang

Modern disease classification often overlooks molecular commonalities hidden beneath divergent clinical presentations. This study introduces a transcriptomics-driven framework for discovering disease relationships by analyzing over 1300…

Genomics · Quantitative Biology 2025-08-08 Ke Chen , Haohan Wang

The adoption of machine learning (ML) and deep learning methods has revolutionized molecular medicine by driving breakthroughs in genomics, transcriptomics, drug discovery, and biological systems modeling. The increasing quantity,…

Multi-agent systems (MAS) have emerged as a promising paradigm for solving complex tasks. Recent work has explored self-evolving MAS that automatically optimize agent capabilities or communication topologies. However, existing methods…

Computation and Language · Computer Science 2026-05-12 Chen Xu , Yicheng Hu , Ruizi Wang , Xinyu Lin , Wenjie Wang , Dongrui Liu , Fuli Feng

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

GenoML is a Python package automating machine learning workflows for genomics (genetics and multi-omics) with an open science philosophy. Genomics data require significant domain expertise to clean, pre-process, harmonize and perform…

Comprehending genomic information is essential for biomedical research, yet extracting data from complex distributed databases remains challenging. Large language models (LLMs) offer potential for genomic Question Answering (QA) but face…

Artificial Intelligence · Computer Science 2026-01-16 Kimia Abedini , Farzad Shami , Gianmaria Silvello

Causal discovery in multi-omic datasets is crucial for understanding the bigger picture of gene regulatory mechanisms, but remains challenging due to high dimensionality, differentiation of direct from indirect relationships, and hidden…

Genomics · Quantitative Biology 2025-05-23 Stephen Asiedu , David Watson

Creating end-to-end bioinformatics workflows requires diverse domain expertise, which poses challenges for both junior and senior researchers as it demands a deep understanding of both genomics concepts and computational techniques. While…

Emerging topics in biomedical research are continuously expanding, providing a wealth of information about genes and their function. This rapid proliferation of knowledge presents unprecedented opportunities for scientific discovery and…

Genomics · Quantitative Biology 2024-12-25 Zhijian Chen , Chuan Hu , Min Wu , Qingqing Long , Xuezhi Wang , Yuanchun Zhou , Meng Xiao

Can we leverage LLMs to model the process of discovering novel language model (LM) architectures? Inspired by real research, we propose a multi-agent LLM approach that simulates the conventional stages of research, from ideation and…

Artificial Intelligence · Computer Science 2025-06-26 Junyan Cheng , Peter Clark , Kyle Richardson

Large language model (LLM)-based multi-agent systems (MAS) show strong promise for complex reasoning, planning, and tool-augmented tasks, but designing effective MAS architectures remains labor-intensive, brittle, and hard to generalize.…

Machine Learning · Computer Science 2026-05-28 Yuntong Hu , Yuting Zhang , Matthew Trager , Yi Zhang , Shuo Yang , Wei Xia , Stefano Soatto

Predicting phenotypes with complex genetic bases based on a small, interpretable set of variant features remains a challenging task. Conventionally, data-driven approaches are utilized for this task, yet the high dimensional nature of…

Machine Learning · Computer Science 2025-04-17 Joseph Lee , Shu Yang , Jae Young Baik , Xiaoxi Liu , Zhen Tan , Dawei Li , Zixuan Wen , Bojian Hou , Duy Duong-Tran , Tianlong Chen , Li Shen

The emergence of Large Language Models (LLMs) in Multi-Agent Systems (MAS) has opened new possibilities for artificial intelligence, yet current implementations face significant challenges in resource management, task coordination, and…

Multiagent Systems · Computer Science 2025-12-03 Junwei Yu , Yepeng Ding , Hiroyuki Sato

Multi-agent systems (MAS) extend large language models (LLMs) from independent single-model reasoning to coordinative system-level intelligence. While existing LLM agents depend on text-based mediation for reasoning and communication, we…

Computation and Language · Computer Science 2025-12-09 Jiaru Zou , Xiyuan Yang , Ruizhong Qiu , Gaotang Li , Katherine Tieu , Pan Lu , Ke Shen , Hanghang Tong , Yejin Choi , Jingrui He , James Zou , Mengdi Wang , Ling Yang

Multi-agent language systems are often built as hand-designed workflows, where agents are assigned semantic roles and communication protocols are specified in advance. We propose NeuroMAS, a method that first treats a multi-agent language…

Artificial Intelligence · Computer Science 2026-05-19 Haoran Lu , Luyang Fang , Wenxuan Zhong , Ping Ma

Large Language Models (LLMs) have demonstrated substantial progress in task automation and natural language understanding. However, without domain expertise in geographic information science (GIS), they continue to encounter limitations…

Software Engineering · Computer Science 2025-12-04 Qianqian Luo , Qingming Lin , Liuchang Xu , Sensen Wu , Ruichen Mao , Chao Wang , Hailin Feng , Bo Huang , Zhenhong Du

Language-driven grasp detection has the potential to revolutionize human-robot interaction by allowing robots to understand and execute grasping tasks based on natural language commands. However, existing approaches face two key challenges.…

Robotics · Computer Science 2025-07-22 Quang Nguyen , Tri Le , Huy Nguyen , Thieu Vo , Tung D. Ta , Baoru Huang , Minh N. Vu , Anh Nguyen

Gene set knowledge discovery is essential for advancing human functional genomics. Recent studies have shown promising performance by harnessing the power of Large Language Models (LLMs) on this task. Nonetheless, their results are subject…

Artificial Intelligence · Computer Science 2024-05-28 Zhizheng Wang , Qiao Jin , Chih-Hsuan Wei , Shubo Tian , Po-Ting Lai , Qingqing Zhu , Chi-Ping Day , Christina Ross , Zhiyong Lu

Cellular research and development (R&D) is throttled by six structural processes that each consume months of manual engineering work per iteration: (i) synthesizing new features from standards or research papers into production code; (ii)…

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