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The evolution of antimicrobial resistance generally occurs in an environment where antimicrobial concentration is variable, which has dramatic consequences on the microorganisms' fitness landscape, and thus on the evolution of resistance.…

Biological Physics · Physics 2018-10-23 Loïc Marrec , Anne-Florence Bitbol

During contagion phenomena, individuals perceiving a risk of infection commonly adapt their behavior and reduce their exposure. The effects of such adaptive mechanisms have been studied for processes in which pairwise interactions drive…

Physics and Society · Physics 2026-01-12 Marco Mancastroppa , Márton Karsai , Alain Barrat

We present a spatially-extended system of chemical reactions exhibiting adaptation to time-dependent influxes of reactants. Here adaptation is defined as improved reproductive success, namely the ability of one of the many locally stable…

Statistical Mechanics · Physics 2025-12-02 Olivier Rivoire , Guy Bunin

The emergence and spread of deadly pandemics has repeatedly occurred throughout history, causing widespread infections and loss of life. The rapid spread of pandemics have made governments across the world adopt a range of actions,…

Populations and Evolution · Quantitative Biology 2024-01-15 Marianna Karapitta , Andreas Kasis , Charithea Stylianides , Kleanthis Malialis , Panayiotis Kolios

Epidemic spreading of infectious diseases is ubiquitous and has often considerable impact on public health and economic wealth. The large variability in spatio-temporal patterns of epidemics prohibits simple interventions and demands for a…

Populations and Evolution · Quantitative Biology 2010-11-25 Christel Kamp

Forecasting disease spread is a critical tool to help public health officials design and plan public health interventions. However, the expected future state of an epidemic is not necessarily well defined as disease spread is inherently…

Populations and Evolution · Quantitative Biology 2026-05-05 Mariah C. Boudreau , Andrea J. Allen , Nicholas J. Roberts , Antoine Allard , Laurent Hébert-Dufresne

Population dynamics is constrained by the environment, which needs to obey certain conditions to support population growth. We consider a standard model for the evolution of a single species population density, that includes reproduction,…

Populations and Evolution · Quantitative Biology 2016-10-18 E. H. Colombo , C. Anteneodo

Human behavior plays a critical role in shaping epidemic trajectories. During health crises, people respond in diverse ways in terms of self-protection and adherence to recommended measures, largely reflecting differences in how individuals…

Physics and Society · Physics 2026-01-30 Fabio Mazza , Gabriele Ricci , Francesca Colaiori , Stefano Guarino , Sandro Meloni , Fabio Saracco

Host mobility plays a fundamental role in the spatial spread of infectious diseases. Previous theoretical works based on the integration of network theory into the metapopulation framework have shown that the heterogeneities that…

Physics and Society · Physics 2013-09-26 Chiara Poletto , Michele Tizzoni , Vittoria Colizza

We introduce a modified SIR model with memory for the dynamics of epidemic spreading in a constant population of individuals. Each individual is in one of the states susceptible (${\bf S}$), infected (${\bf I}$) or recovered (${\bf R}$). In…

Populations and Evolution · Quantitative Biology 2022-03-03 Michael Bestehorn , Thomas M. Michelitsch , Bernard A. Collet , Alejandro P. Riascos , Andrzej F. Nowakowski

Epidemics generally spread through a succession of waves that reflect factors on multiple timescales. On short timescales, super-spreading events lead to burstiness and overdispersion, while long-term persistent heterogeneity in…

Populations and Evolution · Quantitative Biology 2022-05-04 Alexei V. Tkachenko , Sergei Maslov , Ahmed Elbanna , George N. Wong , Zachary J. Weiner , Nigel Goldenfeld

We study the dynamics of epidemic and reaction-diffusion processes in metapopulation models with heterogeneous connectivity pattern. In SIR-like processes, along with the standard local epidemic threshold, the system exhibits a global…

Physics and Society · Physics 2009-11-13 Vittoria Colizza , Alessandro Vespignani

We analyze the long-term stability of a stochastic model designed to illustrate the adaptation of a population to variation in its environment. A piecewise-deterministic process modeling adaptation is coupled to a Feller logistic diffusion…

Probability · Mathematics 2021-09-14 Aurélien Velleret

It is increasingly important to understand the spatial dynamics of epidemics. While there are numerous mathematical models of epidemics, there is a scarcity of physical systems with sufficiently well-controlled parameters to allow…

Motile organisms can form stable agglomerates such as cities or colonies. In the outbreak of a highly contagious disease, the control of large-scale epidemic spread depends on factors like the number and size of agglomerates, travel rate…

Populations and Evolution · Quantitative Biology 2023-04-03 Pablo de Castro , Felipe Urbina , Ariel Norambuena , Francisca Guzmán-Lastra

The evolution of leadership in migratory populations depends not only on costs and benefits of leadership investments but also on the opportunities for individuals to rely on cues from others through social interactions. We derive an…

Adaptation and Self-Organizing Systems · Physics 2013-05-17 Darren Pais , Naomi Ehrich Leonard

The spreading of epidemics is very much determined by the structure of the contact network, which may be impacted by the mobility dynamics of the individuals themselves. In confined scenarios where a small, closed population spends most of…

Physics and Society · Physics 2018-05-09 Clara Granell , Peter J. Mucha

We analyze a nonlocal PDE model describing the dynamics of adaptation of a phenotypically structured population, under the effects of mutation and selection, in a changing environment. Previous studies have analyzed the large-time behavior…

Analysis of PDEs · Mathematics 2020-09-25 Lionel Roques , Florian Patout , Olivier Bonnefon , Guillaume Martin

In the first part of this paper, we review old and new results about the influence of host population heterogeneity on (various characteristics of) epidemic outbreaks. In the second part we highlight a modelling issue that so far has…

Populations and Evolution · Quantitative Biology 2024-01-17 Martin Bootsma , Danny Chan , Odo Diekmann , Hisashi Inaba

The complex interplay between population movements in space and non-homogeneous mixing patterns have so far hindered the fundamental understanding of the conditions for spatial invasion through a general theoretical framework. To address…

Physics and Society · Physics 2014-01-21 Andrea Apolloni , Chiara Poletto , Jose' J. Ramasco , Pablo Jensen , Vittoria Colizza