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The 21st century is presenting humankind with unprecedented environmental and medical challenges. The ability to design novel proteins tailored for specific purposes could transform our ability to respond timely to these issues. Recent…

Biomolecules · Quantitative Biology 2022-08-24 Noelia Ferruz , Birte Höcker

This study demonstrates that generative large language models can be utilized in a more flexible manner for DNA sequence analysis and classification tasks compared to traditional transformer encoder-based models. While recent encoder-based…

Computation and Language · Computer Science 2025-03-07 Hyunwoo Yoo

Controllable Text Generation (CTG) is emerging area in the field of natural language generation (NLG). It is regarded as crucial for the development of advanced text generation technologies that better meet the specific constraints in…

Computation and Language · Computer Science 2023-08-25 Hanqing Zhang , Haolin Song , Shaoyu Li , Ming Zhou , Dawei Song

Controlled Text Generation (CTG) aims to produce texts that exhibit specific desired attributes. In this study, we introduce a pluggable CTG framework for Large Language Models (LLMs) named Dynamic Attribute Graphs-based controlled text…

Computation and Language · Computer Science 2024-05-27 Xun Liang , Hanyu Wang , Shichao Song , Mengting Hu , Xunzhi Wang , Zhiyu Li , Feiyu Xiong , Bo Tang

The impact of Transformer-based language models has been unprecedented in Natural Language Processing (NLP). The success of such models has also led to their adoption in other fields including bioinformatics. Taking this into account, this…

Machine Learning · Computer Science 2025-07-21 Nimisha Ghosh , Daniele Santoni , Debaleena Nawn , Eleonora Ottaviani , Giovanni Felici

Recent studies have adopted pre-trained language models, such as CodeT5 and CodeGPT, for automated program generation tasks like code generation, repair, and translation. Numerous language model-based approaches have been proposed and…

Software Engineering · Computer Science 2024-01-09 Yue Liu , Chakkrit Tantithamthavorn , Yonghui Liu , Li Li

Recent advances in neural-based generative modeling have reignited the hopes of having computer systems capable of conversing with humans and able to understand natural language. The employment of deep neural architectures has been largely…

Computation and Language · Computer Science 2022-11-16 Haoqin Tu , Yitong Li

Designing regulatory DNA sequences that achieve precise cell-type-specific gene expression is crucial for advancements in synthetic biology, gene therapy and precision medicine. Although transformer-based language models (LMs) can…

Machine Learning · Computer Science 2025-05-28 Xingyu Chen , Shihao Ma , Runsheng Lin , Jiecong Lin , Bo Wang

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

Natural Language Generation (NLG) for task-oriented dialogue systems focuses on communicating specific content accurately, fluently, and coherently. While these attributes are crucial for a successful dialogue, it is also desirable to…

Computation and Language · Computer Science 2021-09-28 Alicia Y. Tsai , Shereen Oraby , Vittorio Perera , Jiun-Yu Kao , Yuheng Du , Anjali Narayan-Chen , Tagyoung Chung , Dilek Hakkani-Tur

This research introduces a novel text generation model that combines BERT's semantic interpretation strengths with GPT-4's generative capabilities, establishing a high standard in generating coherent, contextually accurate language. Through…

Computation and Language · Computer Science 2024-11-20 Jiajing Chen , Shuo Wang , Zhen Qi , Zhenhong Zhang , Chihang Wang , Hongye Zheng

Controllable text generation is an appealing but challenging task, which allows users to specify particular attributes of the generated outputs. In this paper, we propose a controllable dialogue generation model to steer response generation…

Computation and Language · Computer Science 2022-10-24 Zhe Hu , Zhiwei Cao , Hou Pong Chan , Jiachen Liu , Xinyan Xiao , Jinsong Su , Hua Wu

Discovery of novel and promising materials is a critical challenge in the field of chemistry and material science, traditionally approached through methodologies ranging from trial-and-error to machine learning-driven inverse design. Recent…

Machine Learning · Computer Science 2024-12-13 Dong Hyeon Mok , Seoin Back

Large Language Models (LLMs) employ three popular training approaches: Masked Language Models (MLM), Causal Language Models (CLM), and Sequence-to-Sequence Models (seq2seq). However, each approach has its strengths and limitations, and…

Machine Learning · Computer Science 2025-02-18 Xuefeng Liu , Songhao Jiang , Bo Li , Rick Stevens

Large-scale language models show promising text generation capabilities, but users cannot easily control particular aspects of the generated text. We release CTRL, a 1.63 billion-parameter conditional transformer language model, trained to…

Computation and Language · Computer Science 2019-09-24 Nitish Shirish Keskar , Bryan McCann , Lav R. Varshney , Caiming Xiong , Richard Socher

This work aims to employ natural language generation (NLG) to rapidly generate items for English language learning applications: this requires both language models capable of generating fluent, high-quality English, and to control the…

Computation and Language · Computer Science 2022-11-30 Kevin Stowe , Debanjan Ghosh , Mengxuan Zhao

In Natural Language Processing (NLP), Large Language Models (LLMs) have demonstrated high text generation quality. However, in real-world applications, LLMs must meet increasingly complex requirements. Beyond avoiding misleading or…

Computation and Language · Computer Science 2024-08-23 Xun Liang , Hanyu Wang , Yezhaohui Wang , Shichao Song , Jiawei Yang , Simin Niu , Jie Hu , Dan Liu , Shunyu Yao , Feiyu Xiong , Zhiyu Li

Language models, especially transformer-based ones, have achieved colossal success in NLP. To be precise, studies like BERT for NLU and works like GPT-3 for NLG are very important. If we consider DNA sequences as a text written with an…

Genomics · Quantitative Biology 2026-01-21 Musa Nuri Ihtiyar , Arzucan Ozgur

Recent advances in large pre-trained language models have demonstrated strong results in generating natural languages and significantly improved performances for many natural language generation (NLG) applications such as machine…

Computation and Language · Computer Science 2022-09-27 Nanyun Peng
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