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Robust machine learning for regulatory genomics is studied under biologically and technically induced distribution shifts. Deep convolutional and attention based models achieve strong in distribution performance on DNA regulatory sequence…

Genomics · Quantitative Biology 2026-02-20 Yiyao Yang

Evolution and learning are two of the fundamental mechanisms by which life adapts in order to survive and to transcend limitations. These biological phenomena inspired successful computational methods such as evolutionary algorithms and…

Neural and Evolutionary Computing · Computer Science 2019-05-10 Jan Schuchardt , Vladimir Golkov , Daniel Cremers

Model explainability is crucial for human users to be able to interpret how a proposed classifier assigns labels to data based on its feature values. We study generalized linear models constructed using sets of feature value rules, which…

Machine Learning · Statistics 2023-11-06 Sanjeeb Dash , Soumyadip Ghosh , Joao Goncalves , Mark S. Squillante

This paper investigates the learnability of the nonlinearity property of Boolean functions using neural networks. We train encoder style deep neural networks to learn to predict the nonlinearity of Boolean functions from examples of…

Machine Learning · Computer Science 2025-02-04 Sriram Ranga , Nandish Chattopadhyay , Anupam Chattopadhyay

Natural evolution gives the impression of leading to an open-ended process of increasing diversity and complexity. If our goal is to produce such open-endedness artificially, this suggests an approach driven by evolutionary metaphor. On the…

Adaptation and Self-Organizing Systems · Physics 2018-12-13 Nicholas Guttenberg , Nathaniel Virgo , Alexandra Penn

The functioning of many biochemical networks is often robust -- remarkably stable under changes in external conditions and internal reaction parameters. Much recent work on robustness and evolvability has focused on the structure of neutral…

Quantitative Methods · Quantitative Biology 2011-03-15 Bryan C. Daniels , Yan-Jiun Chen , James P. Sethna , Ryan N. Gutenkunst , Christopher R. Myers

Reinforcement learning with verifiable rewards (RLVR) has achieved remarkable success in logical reasoning tasks, yet whether large language model (LLM) alignment requires fundamentally different approaches remains unclear. Given the…

Artificial Intelligence · Computer Science 2026-03-12 Zhaowei Zhang , Xiaohan Liu , Xuekai Zhu , Junchao Huang , Ceyao Zhang , Zhiyuan Feng , Yaodong Yang , Xiaoyuan Yi , Xing Xie

AlphaEvolve (Novikov et al., 2025) is a generic evolutionary coding agent that combines the generative capabilities of LLMs with automated evaluation in an iterative evolutionary framework that proposes, tests, and refines algorithmic…

Neural and Evolutionary Computing · Computer Science 2025-12-23 Bogdan Georgiev , Javier Gómez-Serrano , Terence Tao , Adam Zsolt Wagner

Methods of transfer learning try to combine knowledge from several related tasks (or domains) to improve performance on a test task. Inspired by causal methodology, we relax the usual covariate shift assumption and assume that it holds true…

Machine Learning · Statistics 2018-09-25 Mateo Rojas-Carulla , Bernhard Schölkopf , Richard Turner , Jonas Peters

Boolean functions are mathematical objects used in diverse applications. Different applications also have different requirements, making the research on Boolean functions very active. In the last 30 years, evolutionary algorithms have been…

Neural and Evolutionary Computing · Computer Science 2024-02-16 Claude Carlet , Marko Ðurasevic , Domagoj Jakobovic , Stjepan Picek , Luca Mariot

Developing robotic agents that can perform well in diverse environments while showing a variety of behaviors is a key challenge in AI and robotics. Traditional reinforcement learning (RL) methods often create agents that specialize in…

Robotics · Computer Science 2025-03-25 Octi Zhang , Quanquan Peng , Rosario Scalise , Bryon Boots

Finding balanced, highly nonlinear Boolean functions is a difficult problem where it is not known what nonlinearity values are possible to be reached in general. At the same time, evolutionary computation is successfully used to evolve…

Neural and Evolutionary Computing · Computer Science 2022-02-18 Claude Carlet , Marko Djurasevic , Domagoj Jakobovic , Luca Mariot , Stjepan Picek

We initiate the study of fair classifiers that are robust to perturbations in the training distribution. Despite recent progress, the literature on fairness has largely ignored the design of fair and robust classifiers. In this work, we…

Machine Learning · Computer Science 2020-11-05 Debmalya Mandal , Samuel Deng , Suman Jana , Jeannette M. Wing , Daniel Hsu

The planning problem constitutes a fundamental aspect of the autonomous driving framework. Recent strides in representation learning have empowered vehicles to comprehend their surrounding environments, thereby facilitating the integration…

Cognitive modeling commonly relies on asking participants to complete a battery of varied tests in order to estimate attention, working memory, and other latent variables. In many cases, these tests result in highly variable observation…

Machine unlearning poses the challenge of ``how to eliminate the influence of specific data from a pretrained model'' in regard to privacy concerns. While prior research on approximated unlearning has demonstrated accuracy and efficiency in…

Machine Learning · Computer Science 2025-04-21 Khoa Tran , Simon S. Woo

Despite deep learning's success in chemistry, its impact is hindered by a lack of interpretability and an inability to resolve activity cliffs, where minor structural nuances trigger drastic property shifts. Current representation learning,…

Machine Learning · Computer Science 2026-03-26 Xiangsen Chen , Ruilong Wu , Yanyan Lan , Ting Ma , Yang Liu

Evolutionary algorithms have been successful in solving multi-objective optimization problems (MOPs). However, as a class of population-based search methodology, evolutionary algorithms require a large number of evaluations of the objective…

Neural and Evolutionary Computing · Computer Science 2024-08-16 Xueming Yan , Yaochu Jin

Deep learning is computationally intensive, with significant efforts focused on reducing arithmetic complexity, particularly regarding energy consumption dominated by data movement. While existing literature emphasizes inference, training…

Machine Learning · Statistics 2025-06-09 Van Minh Nguyen , Cristian Ocampo , Aymen Askri , Louis Leconte , Ba-Hien Tran

In evolutionary dynamics, the probability that a mutation spreads through the whole population, having arisen in a single individual, is known as the fixation probability. In general, it is not possible to find the fixation probability…

Populations and Evolution · Quantitative Biology 2010-10-26 Valmir C. Barbosa , Raul Donangelo , Sergio R. Souza
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