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We present a model that considers the maturation of the antibody population following primary antigen presentation as a global optimization problem. The trade-off that emerges from our model describes the balance between the safety of…

Quantitative Methods · Quantitative Biology 2007-05-23 Patricia Theodosopoulos , Ted Theodosopoulos

Most efforts in interpretability in deep learning have focused on (1) extracting explanations of a specific downstream task in relation to the input features and (2) imposing constraints on the model, often at the expense of predictive…

Machine Learning · Computer Science 2022-02-22 Marco Bertolini , Djork-Arné Clevert , Floriane Montanari

We present a genetic algorithm framework for automatically discovering deep learning optimization algorithms. Our approach encodes optimizers as genomes that specify combinations of primitive update terms (gradient, momentum, RMS…

Neural and Evolutionary Computing · Computer Science 2025-12-16 Mitchell Marfinetz

This study uses controlled simulations with known ground-truth parameters to evaluate how Distributional Latent Variable Models (DLVM) and Bayesian Distributional Active LEarning (DALE) perform in comparison to conventional Independent…

Boolean formulae compactly encode huge, constrained search spaces. Thus, variability-intensive systems are often encoded with Boolean formulae. The search space of a variability-intensive system is usually too large to explore without…

Logic in Computer Science · Computer Science 2025-03-19 Olivier Zeyen , Maxime Cordy , Martin Gubri , Gilles Perrouin , Mathieu Acher

Machine Learning explainability techniques have been proposed as a means of `explaining' or interrogating a model in order to understand why a particular decision or prediction has been made. Such an ability is especially important at a…

Machine Learning · Statistics 2022-02-28 Matthew J. Vowels

Most of previous machine learning algorithms are proposed based on the i.i.d. hypothesis. However, this ideal assumption is often violated in real applications, where selection bias may arise between training and testing process. Moreover,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-24 Zheyan Shen , Peng Cui , Kun Kuang , Bo Li , Peixuan Chen

Recent work such as AlphaEvolve has shown that combining LLM-driven optimization with evolutionary search can effectively improve programs, prompts, and algorithms across domains. In this paradigm, previously evaluated solutions are reused…

Vision-Language-Action (VLA) models have shown strong performance on embodied manipulation, yet they remain brittle under visual observation changes, paraphrased language instructions, and compounded perturbations. This limitation suggests…

Robotics · Computer Science 2026-05-20 Jingzhou Luo , Yifan Wen , Yongjie Bai , Xinshuai Song , Yang Liu , Liang Lin

The ability of an agent to do well in new environments is a critical aspect of intelligence. In machine learning, this ability is known as $\textit{strong}$ or $\textit{out-of-distribution}$ generalization. However, merely considering…

Machine Learning · Computer Science 2024-02-09 Siyuan Guo , Jonas Wildberger , Bernhard Schölkopf

Game development is a long process that involves many stages before a product is ready for the market. Human play testing is among the most time consuming, as testers are required to repeatedly perform tasks in the search for errors in the…

Machine Learning · Computer Science 2024-01-10 Pierluigi Vito Amadori , Timothy Bradley , Ryan Spick , Guy Moss

Laboratory experiments with bacterial colonies, under well-controlled conditions often lead to evolutionary diversification, where at least two ecotypes emerge from an initially monomorphic population. Empirical evidence suggests that such…

Populations and Evolution · Quantitative Biology 2024-11-06 Roberto Corral López , Samir Suweis , Sandro Azaele , Miguel A. Muñoz

Evolve pairs a small local language model with a persistent, teacher-compiled knowledge store -- refined through sleep consolidation and usage-driven refresh -- to deliver substantial accuracy gains over the model's parametric baseline…

Machine Learning · Computer Science 2026-04-28 Dikran Hovagimian

Evolutionary accumulation models (EvAMs) are an emerging class of machine learning methods designed to infer the evolutionary pathways by which features are acquired. Applications include cancer evolution (accumulation of mutations),…

Populations and Evolution · Quantitative Biology 2026-03-13 Iain G. Johnston

Diversity is an important factor in evolutionary algorithms to prevent premature convergence towards a single local optimum. In order to maintain diversity throughout the process of evolution, various means exist in literature. We analyze…

Neural and Evolutionary Computing · Computer Science 2018-10-31 Thomas Gabor , Lenz Belzner , Claudia Linnhoff-Popien

Deep neural networks, despite their remarkable success, remain fundamentally limited in their ability to perform Continual Learning (CL). While most current methods aim to enhance the capabilities of a single model, Inspired by the…

Machine Learning · Computer Science 2025-08-01 Aojun Lu , Junchao Ke , Chunhui Ding , Jiahao Fan , Jiancheng Lv , Yanan Sun

Implicit policies parameterized by generative models, such as Diffusion Policy, have become the standard for policy learning and Vision-Language-Action (VLA) models in robotics. However, these approaches often suffer from high computational…

Robotics · Computer Science 2025-11-03 Travis Davies , Yiqi Huang , Alexi Gladstone , Yunxin Liu , Xiang Chen , Heng Ji , Huxian Liu , Luhui Hu

Sequential data - ranging from financial time series to natural language - has driven the growing adoption of autoregressive models. However, these algorithms rely on the presence of underlying patterns in the data, and their identification…

Machine Learning · Statistics 2025-10-14 Mario Morawski , Anais Despres , Rémi Rehm

Reinforcement Learning with Verifiable Rewards (RLVR) is a central paradigm for turning large language models (LLMs) into reliable problem solvers, especially in logic-heavy domains. Despite its empirical success, it remains unclear whether…

Machine Learning · Computer Science 2026-01-27 Mingyuan Fan , Weiguang Han , Daixin Wang , Cen Chen , Zhiqiang Zhang , Jun Zhou

A method to control results of gradient descent unsupervised learning in a deep neural network by using evolutionary algorithm is proposed. To process crossover of unsupervisedly trained models, the algorithm evaluates pointwise fitness of…

Machine Learning · Statistics 2018-03-29 Takeshi Inagaki
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