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Mammography and ultrasound are extensively used by radiologists as complementary modalities to achieve better performance in breast cancer diagnosis. However, existing computer-aided diagnosis (CAD) systems for the breast are generally…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Gavriel Habib , Nahum Kiryati , Miri Sklair-Levy , Anat Shalmon , Osnat Halshtok Neiman , Renata Faermann Weidenfeld , Yael Yagil , Eli Konen , Arnaldo Mayer

We study an optimal threshold functional arising in binary classification for continuous biomarkers. While the ROC curve summarizes discriminatory performance across all thresholds, practical threshold selection must also account for…

Methodology · Statistics 2026-05-11 Renato de Paula , Helena Mouriño , Tiago Dias Domingues

Molecular subtyping of breast cancer is crucial for personalized treatment and prognosis. Traditional classification approaches rely on either histopathological images or gene expression profiling, limiting their predictive power. In this…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Amin Honarmandi Shandiz

When evaluating medical tests or biomarkers for disease classification, the area under the receiver-operating characteristic (ROC) curve is a widely used performance metric that does not require us to commit to a specific decision…

Methodology · Statistics 2013-10-21 Wanhua Su , Yan Yuan , Mu Zhu

The receiver operating characteristic (ROC) curve is a very useful tool for analyzing the diagnostic/classification power of instruments/classification schemes as long as a binary-scale gold standard is available. When the gold standard is…

Methodology · Statistics 2011-05-10 Zhanfeng Wang , Yuan-chin Ivan Chang

In recommendation systems, one is interested in the ranking of the predicted items as opposed to other losses such as the mean squared error. Although a variety of ways to evaluate rankings exist in the literature, here we focus on the Area…

Machine Learning · Statistics 2015-08-26 Charanpal Dhanjal , Romaric Gaudel , Stephan Clemencon

The comparison of Receiver Operating Characteristic (ROC) curves is frequently used in the literature to compare the discriminatory capability of different classification procedures based on diagnostic variables. The performance of these…

Receiver operating characteristic (ROC) analysis is one of the most popular approaches for evaluating and comparing the accuracy of medical diagnostic tests. Although various methodologies have been developed for estimating ROC curves and…

Methodology · Statistics 2022-08-16 Ainesh Sewak , Torsten Hothorn

We prove two formulae which express the Alexander polynomial $\Delta^C$ of several variables of a plane curve singularity $C$ in terms of the ring ${\cal O}_{C}$ of germs of analytic functions on the curve. One of them expresses $\Delta^C$…

Algebraic Geometry · Mathematics 2007-05-23 A. Campillo , F. Delgado , S. M. Gusein-Zade

We study the geometry of Receiver Operating Characteristic (ROC) and Precision-Recall (PR) curves in binary classification problems. The key finding is that many of the most commonly used binary classification metrics are merely functions…

Machine Learning · Computer Science 2026-04-15 Reza Sameni

The receiver operating characteristic (ROC) curve and its summary measure, the Area Under the Curve (AUC), are well-established tools for evaluating the efficacy of biomarkers in biomedical studies. Compared to the traditional ROC curve,…

Methodology · Statistics 2025-10-20 Ziad Akram Ali Hammouri , Yating Zou , Rahul Ghosal , Juan C. Vidal , Marcos Matabuena

We determine the gonality and the Clifford index for curves on a compact smooth toric surface. Moreover, it is shown that their gonality are computed by pencils on the ambient surface. From the geometrical view point, this means that the…

Algebraic Geometry · Mathematics 2013-10-22 Ryo Kawaguchi

We give two formulae which express the Alexander polynomial $\Delta^C$ of several variables of a plane curve singularity $C$ in terms of the ring ${\cal O}_{C}$ of germs of analytic functions on the curve. One of them expresses $\Delta^C$…

Algebraic Geometry · Mathematics 2007-05-23 A. Campillo , F. Delgado , S. M. Gusein-Zade

We describe an algorithm, based on the properties of the characteristic polynomials of Frobenius, to compute $\operatorname{End}_{\overline{K}}(A)$ when $A$ is the Jacobian of a nice genus-2 curve over a number field $K$. We use this…

Number Theory · Mathematics 2021-06-02 Davide Lombardo

Area under the ROC curve, a.k.a. AUC, is a measure of choice for assessing the performance of a classifier for imbalanced data. AUC maximization refers to a learning paradigm that learns a predictive model by directly maximizing its AUC…

Machine Learning · Computer Science 2022-08-04 Tianbao Yang , Yiming Ying

Paired comparison models are used for analyzing data that involves pairwise comparisons among a set of objects. When the outcomes of the pairwise comparisons have no ties, the paired comparison models can be generalized as a class of binary…

Methodology · Statistics 2022-11-29 Ran Huo , Mark E. Glickman

The Receiver Operating Characteristic (ROC) curve stands as a cornerstone in assessing the efficacy of biomarkers for disease diagnosis. Beyond merely evaluating performance, it provides with an optimal cutoff for biomarker values, crucial…

Methodology · Statistics 2025-04-29 Soutik Ghosal

We explicitly evaluate the low energy coupling $F_g$ in a $d=4,\mathcal{N}=2$ compactification of the heterotic string. The holomorphic piece of this expression provides the information not encoded in the holomorphic anomaly equations, and…

High Energy Physics - Theory · Physics 2017-09-07 Marcos Marino , Gregory Moore

In this note, we will define the formulas of curvature and it's covariant derivatives for holomorphic curves on C*-algebras for the multivariable case. As applications, the unitarily and similarly classification theorems for holomorphic…

Functional Analysis · Mathematics 2024-03-21 Zhimeng Chen , Jing Xu

In clinical practice, multiple biomarkers are often measured on the same subject for disease diagnosis, and combining them can improve diagnostic accuracy. Existing studies typically combine multiple biomarkers by maximizing the Area Under…

Methodology · Statistics 2025-02-25 Ao Sun , Yanting Li , Xiao-Hua Zhou